Dr. Chang is discussing a project with Hang C.
A long noncoding RNA protects the heart from pathological hypertrophy.
[Han P, et al., Nature. 2014 Aug 10. doi: 10.1038/nature13596.]
CELL Cover Story and HHMI-NIH Scholar Program
Han 2014 Nature
A long noncoding RNA protects the heart from pathological hypertrophy. [Han P, et al., Nature. 2014 Aug 10. doi: 10.1038/nature13596.]
Xiong 2013 Dev. Cell
Brg1 governs a positive feedback circuit in the hair follicle for tissue regeneration and repair. [Xiong Y, et al., Dev. Cell. 2013; 25(2):169-81 Commentary: Mesa KR and Greco V. Linking Morphogen and Chromatin in the hair follicle. Dev Cell 2013;25(2):113-14.]
Li 2013 PNAS
Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. [Li W, et al., Proc Natl Acad Sci 2013; 110 (5): 1738-43.]
Chang 2012 Ann Review of Physiology
Chang CP and Bruneau B. Epigenetics and cardiovascular development. [Annual Review of Physiology 2012; 74:13.1–13.28.]
Han 2012 Circulation Research
Chromatin remodeling in cardiovascular development and physiology. [Han P, et al., Circulation Research 2011; 108: 378-96.]
Hang 2010 Nature
Chromatin regulation by Brg1 underlies heart muscle development and disease. [Hang C, et al., Nature 2010; 466(7302): 62-67.]
Stankunas 2008 Dev. Cell
Endocardial Brg1 represses ADAMTS1 proteases to maintain the microenvronment for myocardial morphogenesis. [Stankunas K, et al., Dev. Cell 2008;14(2):298-311.]
Chang 2004 Cell
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. [Chang CP, et al., Cell 2004;118, 649-663. Cover story. Editorial commentary: Carmeliet P. Sculpting heart valves with NFAT and VEGF. Cell 2004;118, 532-534.]
Our goal is to define the molecular mechanisms underlying cardiomyopathy and heart failure and translate bench findings to clinical applications. We are establishing an epigenetic framework within which cardiac stress activates epigenomic changes in the heart to reprogram cardiac gene expression, causing cardiomyopathy. We have identified several new chromatin regulators that are stress-regulated to control cardiac hypertrophy and failure. These regulators include chromatin-remodeling factors, histone and DNA modifying enzymes, transcription co-factors, microRNA, and long non-coding RNA (LncRNA). Understanding the epigenetic mechanisms that underlie heart failure will facilitate drug discovery process and the development of epigenetic therapy for heart failure.
Area of interests:
Heart failure, Heart development, Genetics, Epigenetics