SCHOOL OF MEDICINE

Department of Medicine

C.P. Chang Laboratory

Heart Valve Morphogenesis

Using pharmacological inhibitors, tissue-specific gene disruption and conventional gene knockout in mice, we have demonstrated that calcineurin/NFAT signaling plays two sequential and critical roles in the initiation and propagation of heart valve morphogenesis. The initiation of valve formation requires myocardial NFAT to repress the expression of VEGF (vascular endothelial growth factor). We are studying how VEGF interacts with NFAT signaling during valve formation, and the molecular mechanism of NFAT-mediated VEGF repression.

Heart Valve Formation   NFAT Signaling
Heart Valve Formation and NFAT Signaling