SCHOOL OF MEDICINE

Department of Medicine

C.P. Chang Laboratory

Patterning of Cardiac Outflow Tract and Great Arteries

Using compound gene mutations in mice, we have demonstrated that Pbx gene family members (homeodomain proto-oncogenes) are essential for the patterning of cardiac outflow tracts and great arteries. We are investigating the molecular pathways controlled by Pbx genes during cardiac development.

Embryonic Heart Angiogram

Embryoinic
Heart Angiogram