SCHOOL OF MEDICINE

Department of Medicine

Endocrinology

What Is LDL Apheresis?

Low-density lipoprotein (LDL) is the major cholesterol carrying lipoprotein in your blood. LDL apheresis is a procedure that takes blood outside the body to remove the LDL-cholesterol and then returns the plasma and blood back to the body. This procedure is used if diet or lipid-lowering drug therapy has not lowered high LDL-cholesterol levels adequately.

Dr. Amale Lteif evaluates patients who might e candidates for LDDL apheresis and overseas this procedure which is performed at Spring Mill Indiana University Infusion Center using the LIPOSORBER system.

 

Who Qualifies?

LDL Chol Description
  500 Patients with functional homozygous hypercholesterolemia having LDL-cholesterol levels above 500 mg/dl
  300 Patients with LDL-cholesterol levels > 300 mg/dl. Most patients in this group are severe functional hypercholesterolemic heterozygotes.
  200 Functional hypercholesterolemic heterozygotes having LDL-cholesterol levels > 200 mg/dl with documented heart disease (CHD).

Staff

Dr. Amale Lteif

Christine Diene, Lipid Apheresis Technician, Certified Medical Asst.


News



Publications

  1. Bosch T, Wendler T
    State of the Art of Low-density Lipoprotein Apheresis in the Year 2003. Ther Apher Dial 8:76-79, 2004.
    Abstract
  2. Mellwig KP
    Heparin-induced extracorporeal low-density lipoprotein precipitation. Ther Apher Dial 7:365-369, 2003.
    Abstract
  3. Matsuzaki M, Hiramori K, Imaizumi T, Kitabatake A, Hishida H, Nomura M, Fujii T, Sakuma I, Fukami K, Honda T, Ogawa H, Yamagishi M
    Intravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: the Low Density Lipoprotein-Apheresis Coronary Morphology and Reserve Trial (LACMART). J Am Coll Cardiol 40:220-227, 2002.
    Abstract
  4. Moriarty PM, Gibson CA, Shih J, Matias MS
    C-reactive protein and other markers of inflammation among patients undergoing HELP LDL apheresis. Atherosclerosis 158:495-498, 2001.
    Abstract
  5. Moriarty PM, Gibson CA
    Low-density lipoprotein apheresis in the treatment of atherosclerosis and other potential uses. Curr Atheroscler Rep 3:156-162, 2001.
    Abstract
  6. Mabuchi H, Koizumi J, Shimizu M, Kajinami K, Miyamoto S, Ueda K, Takegoshi T
    Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group. Am J Cardiol 82:1489-1495, 1998.
    Abstract
  7. Kajinami K, Mabuchi H
    Therapeutic effects of LDL apheresis in the prevention of atherosclerosis. Curr Opin Lipidol 10:401-406, 1999.
    Abstract