SCHOOL OF MEDICINE

Department of Medicine

Gastroenterology Hepatology

Research - PHS/National Institutes of Health

UO1 DK61737 (Chalasani) NIH - NIDDK 5/20/02 - 4/30/09
Collaborative Clinical Research on Non-Alcoholic Steatohepatitis
The major goal of this co-operative agreement is to participate in a multi-centered study on NASH to define its natural history and to identify suitable therapeutic agents.
UO1 DK065211 (Chalasani) NIH - NIDDK 9/30/03 - 8/31/08
Collaborative clinical research on drug hepatotoxicity
The major goal of this grant is to participate in multicenter studies of etiology, pathogenesis and outcome of patients with drug hepatotoxicity.
K24 DK069290 (Chalasani) NIH - NIDDK 9/30/05 - 8/31/10
Patient-Oriented Research of Liver Disease
This is a mid-career investigator award to support research and mentorship in patient-oriented research.
R01 DK074627 (Chalasani) NIH - NIDDK 02/01/07 - 01/31/08
Nonalcoholic steatohepatitis and Cytochrome P450 Enzymes
This proposal investigates the role of microsomal enzymes in the pathogenesis of nonalcoholic steatohepatitis in adults and children. It has four specific aims.
R01 AA015070 (Crabb) NIH - NIAAA 08/01/04 - 07/31/09
Effects of ethanol on AMP kinase signaling
This project investigates the mechanisms by which exposure of hepatocytes to ethanol inhibits AMPK and how this influences the disposition of fat in the liver.
P60 AA007611 (Crabb) NIH - NIAAA 12/01/07 - 11/30/12
Genetic Determinants on Alcohol Ingestion
The aims of this grant are to 1) provide support to alcohol researchers through provision of cores for animal production, and genomic, and molecular biology analyses and interpretation, 2) continue selective breeding and characterization of alcohol-preferring mice 3) determine gene expression differences between the hippocampus and nucleus accumbens of alcohol-preferring and non-preferring rats, 4) analyze strain differences in susceptibility of mouse fetuses to alcohol in an embryo culture system, 5) analyze brain responses to alcohol exposure as a function of family history of alcoholism and alcohol clamping, and 6) provide support for pilot studies in alcohol research.
R01 CA104459 (Imperiale) NIH - NCI 8/10/04 - 5/31/10
Quantifying Risk to Target Screening Colonoscopy
The goal of the study is to improve the efficiency and cost-effectiveness of colorectal cancer screening. We are enrolling 4,000-5,000 persons undergoing first time screening colonoscopy to determine exactly who needs, and who does not need, colonoscopic screening. The specific aims of the study are: 1) To derive clinical prediction rules that stratify risk for advanced neoplasia (colorectal cancer and advanced, premalignant polyps) a) anywhere in the large intestine (to target the timing and intensity of initial screening, and b) in the proximal colon (to target use of colonoscopy after sigmoidoscopy) 2. To establish a serum and DNA repository for future testing of biomarkers for predicting immediate and long-term risk of advanced colorectal neoplasia.
K24 DK002756 (Imperiale) NIH - NIDDK 9/01/04 - 8/31/09
Using risk to tailor management of digestive diseases
This grant is a mid-career investigator career-development award which is geared toward conducting patient-oriented research and to mentoring trainees and junior faculty who are doing clinical research. The overall objective of the research part of this grant is to extend the concepts of understanding and applying risk to the domains of prevention, diagnosis, treatment, and prognosis to the clinical areas of screening for colorectal cancer, diagnosis of advanced liver disease, treatment to prevent variceal hemorrhage, and management of acute upper GI hemorrhage.

The objective of the mentoring part of this award is to mentor fellows and junior faculty to conduct meaningful, high-quality patient-oriented research by teaching principles of clinical epidemiology and research design, and by guiding them to obtain funding, particularly through the NIH and VA funding pathways.
K08 AA016570 (Liangpunsakul) NIH - NIAAA 04/01/08 - 03/31/13
Effect of ethanol on Kupffer cell/hepatocyte interactions and lipid metabolism
R24 AA015512 (Lumeng) NIH - NIAAA 7/01/05 - 6/30/10
Rodents with Genetic Differences in Alchohol Preference
The goals of this grant are to continue selection of the replicate High (HAD1 and HAD2) and Low (LAD1 and LAD2) Alcohol Drinking Rat Lines and provide P/NP, inbred P/NP and HAD/LAD rats to outside investigators. This grant also allows extra breeding of selectively bred High and Low-Alcohol Preferring (HAP1 and HAP2/LAP1 and LAP2) lines of mice for outside investigators interested in using these mice in their research.