SCHOOL OF MEDICINE

Department of Medicine

Indiana Center for Biological Microscopy

Research

In addition to providing microscopy support for numerous NIH-supported investigators, the Center is also actively involved in research into biological imaging, resulting in the development and dissemination of new methods of microscopy and digital image analysis software. The products of these activities are disseminated through a program of education, including seminars, courses and individual training. Publications resulting from ICBM imaging research, and utilizing ICBM imaging facilities are listed below.

Publications Utilizing the Imaging Facility

Peer reviewed publications resulting from Indiana Center for Biological Microscopy Resources are listed by year below. Papers in which images acquired either contributed to the body of the work or appeared as part of the published paper are shown.

2013

  • Plowman, E. K., Bijangi-Vishehsaraei, K., Halum, S., Cates, D., Hanenberg, H., Domer, A. S., Nolta, J. A., and Belafsky, P. C. (2013) Autologous myoblasts attenuate atrophy and improve tongue force in a denervated tongue model: A pilot study, The Laryngoscope.

  • Soonpaa, M. H., Rubart, M., and Field, L. J. (2013) Challenges measuring cardiomyocyte renewal, Biochimica et biophysica acta 1833, 799-803.

  • Tell, G., Di Piazza, M., Kamocka, M. M., and Vascotto, C. (2013) Combining RNAi and in vivo confocal microscopy analysis of the photoconvertible fluorescent protein Dendra2 to study a DNA repair protein, BioTechniques 55, 198-203.

  • Chen, Y., Ozturk, N. C., and Zhou, F. C. (2013) DNA methylation program in developing hippocampus and its alteration by alcohol, PloS one 8, e60503.

  • Koehler, K. R., Mikosz, A. M., Molosh, A. I., Patel, D., and Hashino, E. (2013) Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture, Nature 500, 217-221.

  • Chang, P. C., Turker, I., Lopshire, J. C., Masroor, S., Nguyen, B. L., Tao, W., Rubart, M., Chen, P. S., Chen, Z., and Ai, T. (2013) Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles, Journal of the American Heart Association 2, e004713.

  • Clendenon, S. G., Ward, H. H., Dunn, K. W., and Bacallao, R. (2013) High resolution 4-dimension imaging of metanephric embryonic kidney morphogenesis, Kidney international 83, 757-761.

  • Hall, A. M., Rhodes, G. J., Sandoval, R. M., Corridon, P. R., and Molitoris, B. A. (2013) In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury, Kidney international 83, 72-83.

  • Werner, M. E., Ward, H. H., Phillips, C. L., Miller, C., Gattone, V. H., and Bacallao, R. L. (2013) Inversin modulates the cortical actin network during mitosis, American journal of physiology. Cell physiology 305, C36-47.

  • Molitoris, B. A. (2013) Measuring glomerular filtration rate in the intensive care unit: no substitutes please, Critical care (London, England) 17, 181.

  • VanDuyn, N., Settivari, R., LeVora, J., Zhou, S., Unrine, J., and Nass, R. (2013) The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration, Journal of neurochemistry 124, 147-157.

  • Corridon, P. R., Rhodes, G. J., Leonard, E. C., Basile, D. P., Gattone, V. H., 2nd, Bacallao, R. L., and Atkinson, S. J. (2013) A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors, American journal of physiology. Renal physiology 304, F1217-1229.

  • Rudgalvyte, M., VanDuyn, N., Aarnio, V., Heikkinen, L., Peltonen, J., Lakso, M., Nass, R., and Wong, G. (2013) Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific miRNAs in Caenorhabditis elegans, Toxicology letters 222, 189-196.

  • Settivari, R., VanDuyn, N., LeVora, J., and Nass, R. (2013) The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism, Neurotoxicology 38, 51-60.

  • Kalwat, M. A., Yoder, S. M., Wang, Z., and Thurmond, D. C. (2013) A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic beta cells, Biochemical pharmacology 85, 808-816.

  • Sutton, T. A., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. J., and Dagher, P. C. (2013) p53 is renoprotective after ischemic kidney injury by reducing inflammation, Journal of the American Society of Nephrology : JASN 24, 113-124.

  • Didie, M., Christalla, P., Rubart, M., Muppala, V., Doker, S., Unsold, B., El-Armouche, A., Rau, T., Eschenhagen, T., Schwoerer, A. P., Ehmke, H., Schumacher, U., Fuchs, S., Lange, C., Becker, A., Tao, W., Scherschel, J. A., Soonpaa, M. H., Yang, T., Lin, Q., Zenke, M., Han, D. W., Scholer, H. R., Rudolph, C., Steinemann, D., Schlegelberger, B., Kattman, S., Witty, A., Keller, G., Field, L. J., and Zimmermann, W. H. (2013) Parthenogenetic stem cells for tissue-engineered heart repair, The Journal of clinical investigation 123, 1285-1298.

  • Byrd, D., Amet, T., Hu, N., Lan, J., Hu, S., and Yu, Q. (2013) Primary human leukocyte subsets differentially express vaccinia virus receptors enriched in lipid rafts, Journal of virology 87, 9301-9312.

  • Sandoval, R. M., and Molitoris, B. A. (2013) Quantifying glomerular permeability of fluorescent macromolecules using 2-photon microscopy in Munich Wistar rats, Journal of visualized experiments : JoVE.

  • Hato, T., El-Achkar, T. M., and Dagher, P. C. (2013) Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity, American journal of physiology. Renal physiology 304, F1243-1251.

  • Lee, J. H., Hong, K. S., Mantel, C., Broxmeyer, H. E., Lee, M. R., and Kim, K. S. (2013) Spontaneously differentiated GATA6-positive human embryonic stem cells represent an important cellular step in human embryonic development; they are not just an artifact of in vitro culture, Stem cells and development 22, 2706-2713.

  • McDonald, J. H., and Dunn, K. W. (2013) Statistical tests for measures of colocalization in biological microscopy, Journal of microscopy.

  • El-Achkar, T. M., McCracken, R., Liu, Y., Heitmeier, M. R., Bourgeois, S., Ryerse, J., and Wu, X. R. (2013) Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury, American journal of physiology. Renal physiology 304, F1066-1075.

  • Herbert, B. S., Grimes, B. R., Xu, W. M., Werner, M., Ward, C., Rossetti, S., Harris, P., Bello-Reuss, E., Ward, H. H., Miller, C., Gattone, V. H., 2nd, Phillips, C. L., Wandinger-Ness, A., and Bacallao, R. L. (2013) A telomerase immortalized human proximal tubule cell line with a truncation mutation (Q4004X) in polycystin-1, PloS one 8, e55191.

 

2012

  • Choong, F. X., Sandoval, R. M., Molitoris, B. A., and Richter-Dahlfors, A. (2012) Multiphoton microscopy applied for real-time intravital imaging of bacterial infections in vivo, Methods Enzymol 506, 35-61.

  • Clendenon, S. G., Sarmah, S., Shah, B., Liu, Q., and Marrs, J. A. (2012) Zebrafish cadherin-11 participates in retinal differentiation and retinotectal axon projection during visual system development, Dev Dyn 241, 442-454.

  • Dagher, P. C., Mai, E. M., Hato, T., Lee, S. Y., Anderson, M. D., Karozos, S. C., Mang, H. E., Knipe, N. L., Plotkin, Z., and Sutton, T. A. (2012) The p53 inhibitor pifithrin-alpha can stimulate fibrosis in a rat model of ischemic acute kidney injury, Am J Physiol Renal Physiol 302, F284-291.

  • Kalwat, M. A., Wiseman, D. A., Luo, W., Wang, Z., and Thurmond, D. C. (2012) Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis, Mol Endocrinol 26, 128-141.

  • Lahm, T., Albrecht, M., Fisher, A. J., Selej, M., Patel, N. G., Brown, J. A., Justice, M. J., Brown, M. B., Van Demark, M., Trulock, K. M., Dieudonne, D., Reddy, J. G., Presson, R. G., and Petrache, I. (2012) 17-Beta Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor-mediated Effects, Am J Respir Crit Care Med.

  • Sandoval, R. M., Wagner, M. C., Patel, M., Campos-Bilderback, S. B., Rhodes, G. J., Wang, E., Wean, S. E., Clendenon, S. S., and Molitoris, B. A. (2012) Multiple factors influence glomerular albumin permeability in rats, J Am Soc Nephrol 23, 447-457.

  • Wang, E., Meier, D. J., Sandoval, R. M., Von Hendy-Willson, V. E., Pressler, B. M., Bunch, R. M., Alloosh, M., Sturek, M. S., Schwartz, G. J., and Molitoris, B. A. (2012) A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals, Kidney Int 81, 112-117.

  • Xu, Z., Kim, O., Kamocka, M., Rosen, E. D., and Alber, M. (2012) Multiscale models of thrombogenesis, Wiley Interdiscip Rev Syst Biol Med.

  • Basile, D. P., Zeng, P., Friedrich, J. L., Leonard, E. C., and Yoder, M. C. (2012) Low proliferative potential and impaired angiogenesis of cultured rat kidney endothelial cells, Microcirculation.

  • Benson, H. L., Suzuki, H., Lott, J., Fisher, A. J., Walline, C., Heidler, K. M., Brutkiewicz, R., Blum, J. S., and Wilkes, D. S. (2012) Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production, Respir Res 13, 25.

  • Broxmeyer, H. E., Christopherson, K., Hangoc, G., Cooper, S., Mantel, C., Renukaradhya, G. J., and Brutkiewicz, R. R. (2012) CD1d expression on and regulation of murine hematopoietic stem and progenitor cells, Blood 119, 5731-5741.

  • Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J., and Brutkiewicz, R. R. (2012) Regulation of the Actin Cytoskeleton by Rho Kinase Controls Antigen Presentation by CD1d, J Immunol.

  • Green, L. A., Kim, C., Gupta, S. K., Rajashekhar, G., Rehman, J., and Clauss, M. (2012) Pentoxifylline Reduces Tumor Necrosis Factor-alpha and HIV-Induced Vascular Endothelial Activation, AIDS Res Hum Retroviruses.

  • Habegger, K. M., Penque, B. A., Sealls, W., Tackett, L., Bell, L. N., Blue, E. K., Gallagher, P. J., Sturek, M., Alloosh, M. A., Steinberg, H. O., Considine, R. V., and Elmendorf, J. S. (2012) Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle, Diabetologia 55, 457-467.

  • Halum, S. L., McRae, B., Bijangi-Vishehsaraei, K., and Hiatt, K. (2012) Neurotrophic factor-secreting autologous muscle stem cell therapy for the treatment of laryngeal denervation injury, Laryngoscope.

  • Huang, R., Li, M., and Gregory, R. L. (2012) Effect of nicotine on growth and metabolism of Streptococcus mutans, Eur J Oral Sci 120, 319-325.

  • Imamura, R., Isaka, Y., Sandoval, R. M., Ichimaru, N., Abe, T., Okumi, M., Yazawa, K., Kitamura, H., Kaimori, J., Nonomura, N., Rakugi, H., Molitoris, B. A., and Takahara, S. (2012) A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney, Clin Exp Nephrol.

  • K Sharma, A., Lu, G., Jester, A., Saadatzadeh, M. R., Laubach, V. E., Murphy, M. P., Ailawadi, G., and Upchurch, G. R. J. (2012) Mesenchymal Stem Cells Attenuate Experimental Abdominal Aortic Aneurysm Formation via Inhibition of IL-17, Circulation (accepted, June 2012).

  • Layton, A. T., Dantzler, W. H., and Pannabecker, T. L. (2012) Urine concentrating mechanism: impact of vascular and tubular architecture and a proposed descending limb urea-Na+ cotransporter, Am J Physiol Renal Physiol 302, F591-605.

  • Layton, A. T., Gilbert, R. L., and Pannabecker, T. L. (2012) Isolated interstitial nodal spaces may facilitate preferential solute and fluid mixing in the rat renal inner medulla, Am J Physiol Renal Physiol 302, F830-839.

  • Li, M., Huang, R., Zhou, X., and Gregory, R. L. (2012) Effect of nicotine on competition and coexistence between Streptococcus sanguimis in in vitrobiofilms, Arch. Oral Biology (in press).

  • McRae, B. R., Shew, M., Aaron, G. P., Bijangi-Vishehsaraei, K., and Halum, S. L. (2012) A rapid, novel model of culturing cranial nerve X-derived motoneurons for screening trophic factor outgrowth response, Neurol Res 34, 564-575.

  • Moberly, S. P., Berwick, Z. C., Kohr, M., Svendsen, M., Mather, K. J., and Tune, J. D. (2012) Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow, Exp Biol Med (Maywood) 237, 334-342.

  • Nassar, H. M., Li, M., and Gregory, R. L. (2012) Effect of honey on Streptococcus mutans growth and biofilm formation, Appl Environ Microbiol 78, 536-540.

  • Pannabecker, T. (2012) Renal Structure and Function of Desert Rodents, National Science Foundation IOS-0952885.

  • Pannabecker, T. (2012) Integrated Tubular and Vascular Structure and Function in Renal Inner Medulla, NIH/NIDDK 1 R01 DK083338-01A2.

  • Payne, R. M., and Peverill, R. E. (2012) Cardiomyopathy of Friedreich's Ataxia (FRDA), Ir J Med Sci.

  • Payne, R. M., and Wagner, G. R. (2012) Cardiomyopathy in Friedreich Ataxia: Clinical Findings and Research, J Child Neurol.

  • Rajashekhar, G., Gupta, A., Marin, A., Friedrich, J., Willuweit, A., Berg, D. T., Cramer, M. S., Sandusky, G. E., Sutton, T. A., Basile, D. P., Grinnell, B. W., and Clauss, M. (2012) Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice, Am J Physiol Renal Physiol 302, F703-712.

  • Saleh, M. A., Sandoval, R. M., Rhodes, G. J., Campos-Bilderback, S. B., Molitoris, B. A., and Pollock, D. M. (2012) Chronic endothelin-1 infusion elevates glomerular sieving coefficient and proximal tubular albumin reuptake in the rat, Life Sci.

  • Tao, W., Soonpaa, M. H., Field, L. J., Chen, P. S., Firulli, A. B., Shou, W., and Rubart, M. (2012) Functional screening of intracardiac cell transplants using two-photon fluorescence microscopy, Pediatr Cardiol 33, 929-937.

  • Tolar, J., Becker, P. S., Clapp, D. W., Hanenberg, H., de Heredia, C. D., Kiem, H. P., Navarro, S., Qasba, P., Rio, P., Schmidt, M., Sevilla, J., Verhoeyen, E., Thrasher, A. J., and Bueren, J. (2012) Gene therapy for fanconi anemia: one step closer to the clinic, Hum Gene Ther 23, 141-144.

  • Turek, J., Ebetino, F. H., Lundy, M. W., Sun, S., Kashemirov, B. A., McKenna, C. E., Gallant, M. A., Plotkin, L. I., Bellido, T., Duan, X., Triffitt, J. T., Russell, R. G., Burr, D. B., and Allen, M. R. (2012) Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits, Calcif Tissue Int 90, 202-210.

  • Urity, V. B., Issaian, T., Braun, E. J., Dantzler, W. H., and Pannabecker, T. L. (2012) Architecture of kangaroo rat inner medulla: segmentation of descending thin limb of Henle's loop, Am J Physiol Regul Integr Comp Physiol 302, R720-726.

  • Vyas, P. M., Tomamichel, W. J., Pride, P. M., Babbey, C. M., Wang, Q., Mercier, J., Martin, E. M., and Payne, R. M. (2012) A TAT-frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model, Hum Mol Genet 21, 1230-1247.

  • Wagner, G. R., Pride, P. M., Babbey, C. M., and Payne, R. M. (2012) Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase, Hum Mol Genet 21, 2688-2697.

  • Weng, Y., Howard, L., Chong, V. J., Sun, J., Gregory, R. L., and Xie, D. (2012) A novel furanone-modified antibacterial dental glass ionomer cement, Acta Biomater 8, 3153-3160.

  • Weng, Y., Howard, L., Guo, X., Chong, V. J., Gregory, R. L., and Xie, D. (2012) A novel antibacterial resin composite for improved dental restoratives, J Mater Sci Mater Med 23, 1553-1561.

  • Yang, J. J., Kularatne, S. A., Chen, X., Low, P. S., and Wang, E. (2012) Characterization of in vivo disulfide-reduction mediated drug release in mouse kidneys, Mol Pharm 9, 310-317.

  • Zhou, Y., Holmseth, S., Hua, R., Lehre, A. C., Olofsson, A. M., Poblete-Naredo, I., Kempson, S. A., and Danbolt, N. C. (2012) The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface, Am J Physiol Renal Physiol 302, F316-328.

  • Basavarajappa, H. D., and Corson, T. W. (2012) KIF14 as an oncogene in retinoblastoma: a target for novel therapeutics?, Future Med Chem 4, 2149-2152.

  • Basile, D. P., Zeng, P., Friedrich, J. L., Leonard, E. C., and Yoder, M. C. (2012) Low proliferative potential and impaired angiogenesis of cultured rat kidney endothelial cells, Microcirculation 19, 598-609.

  • Broxmeyer, H. E. (2012) Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function, Ann N Y Acad Sci 1266, 151-160.

  • Broxmeyer, H. E., Etienne-Julan, M., Gotoh, A., Braun, S. E., Lu, L., Cooper, S., Feng, G. S., Li, X. J., and Chan, R. J. (2012) Hematopoietic Colony Formation from Human Growth Factor-Dependent TF1 Cells and Human Cord Blood Myeloid Progenitor Cells Depends on SHP2 Phosphatase Function, Stem Cells Dev.

  • Broxmeyer, H. E., Hoggatt, J., O'Leary, H. A., Mantel, C., Chitteti, B. R., Cooper, S., Messina-Graham, S., Hangoc, G., Farag, S., Rohrabaugh, S. L., Ou, X., Speth, J., Pelus, L. M., Srour, E. F., and Campbell, T. B. (2012) Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis, Nat Med 18, 1786-1796.

  • Casbon, A. J., Long, M. E., Dunn, K. W., Allen, L. A., and Dinauer, M. C. (2012) Effects of IFN-gamma on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558, J Leukoc Biol 92, 869-882.

  • Chen, P. S., Ogawa, M., Maruyama, M., Chua, S. K., Chang, P. C., Rubart-von der Lohe, M., Chen, Z., Ai, T., and Lin, S. F. (2012) Imaging arrhythmogenic calcium signaling in intact hearts, Pediatr Cardiol 33, 968-974.

  • Choi, M. R., Bardhan, R., Stanton-Maxey, K. J., Badve, S., Nakshatri, H., Stantz, K. M., Cao, N., Halas, N. J., and Clare, S. E. (2012) Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse, Cancer Nanotechnol 3, 47-54.

  • Crotzer, V. L., Matute, J. D., Arias, A. A., Zhao, H., Quilliam, L. A., Dinauer, M. C., and Blum, J. S. (2012) Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells, J Immunol 189, 3800-3804.

  • Dunn, K. W., Sutton, T. A., and Sandoval, R. M. (2012) Live-animal imaging of renal function by multiphoton microscopy, Curr Protoc Cytom Chapter 14, Unit12 19.

  • Gallo, R. M., Khan, M. A., Shi, J., Kapur, R., Wei, L., Bailey, J. C., Liu, J., and Brutkiewicz, R. R. (2012) Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d, J Immunol 189, 1689-1698.

  • Green, L. A., Kim, C., Gupta, S. K., Rajashekhar, G., Rehman, J., and Clauss, M. (2012) Pentoxifylline reduces tumor necrosis factor-alpha and HIV-induced vascular endothelial activation, AIDS Res Hum Retroviruses 28, 1207-1215.

  • Green, L. A., Petrusca, D., Rajashekhar, G., Gianaris, T., Schweitzer, K. S., Wang, L., Justice, M. J., Petrache, I., and Clauss, M. (2012) Cigarette Smoke-Induced CXCR3 Receptor Up-Regulation Mediates Endothelial Apoptosis, Am J Respir Cell Mol Biol 47, 807-814.

  • Hall, A. M., Rhodes, G. J., Sandoval, R. M., Corridon, P. R., and Molitoris, B. A. (2012) In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury, Kidney Int.

  • Halum, S. L., McRae, B., Bijangi-Vishehsaraei, K., and Hiatt, K. (2012) Neurotrophic factor-secreting autologous muscle stem cell therapy for the treatment of laryngeal denervation injury, Laryngoscope 122, 2482-2496.

  • Hiatt, K., Lewis, D., Shew, M., Bijangi-Vishehsaraei, K., and Halum, S. (2012) Ciliary neurotrophic factor (CNTF) promotes skeletal muscle progenitor cell (MPC) viability via the phosphatidylinositol 3-kinase-Akt pathway, J Tissue Eng Regen Med.

  • Huda, N., Abe, S., Gu, L., Mendonca, M. S., Mohanty, S., and Gilley, D. (2012) Recruitment of TRF2 to laser-induced DNA damage sites, Free Radic Biol Med 53, 1192-1197.

  • Kanakasabai, S., Pestereva, E., Chearwae, W., Gupta, S. K., Ansari, S., and Bright, J. J. (2012) PPARgamma Agonists Promote Oligodendrocyte Differentiation of Neural Stem Cells by Modulating Stemness and Differentiation Genes, PLoS One 7, e50500.

  • Kelly, K. J., Zhang, J., Wang, M., Zhang, S., and Dominguez, J. H. (2012) Intravenous renal cell transplantation for rats with acute and chronic renal failure, Am J Physiol Renal Physiol 303, F357-365.

  • Liu, F., and Korc, M. (2012) Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells, Mol Cancer Ther 11, 2138-2148.

  • Mali, R. S., Ma, P., Zeng, L. F., Martin, H., Ramdas, B., He, Y., Sims, E., Nabinger, S., Ghosh, J., Sharma, N., Munugalavadla, V., Chatterjee, A., Li, S., Sandusky, G., Craig, A. W., Bunting, K. D., Feng, G. S., Chan, R. J., Zhang, Z. Y., and Kapur, R. (2012) Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT, Blood 120, 2669-2678.

  • Oh, E., Kalwat, M. A., Kim, M. J., Verhage, M., and Thurmond, D. C. (2012) Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms, J Biol Chem 287, 25821-25833.

  • Rinker, S. D., Gu, X., Fortney, K. R., Zwickl, B. W., Katz, B. P., Janowicz, D. M., Spinola, S. M., and Bauer, M. E. (2012) Permeases of the sap transporter are required for cathelicidin resistance and virulence of Haemophilus ducreyi in humans, J Infect Dis 206, 1407-1414.

  • Sawant, D. V., Sehra, S., Nguyen, E. T., Jadhav, R., Englert, K., Shinnakasu, R., Hangoc, G., Broxmeyer, H. E., Nakayama, T., Perumal, N. B., Kaplan, M. H., and Dent, A. L. (2012) Bcl6 controls the th2 inflammatory activity of regulatory T cells by repressing gata3 function, J Immunol 189, 4759-4769.

  • Soonpaa, M. H., Rubart, M., and Field, L. J. (2012) Challenges measuring cardiomyocyte renewal, Biochim Biophys Acta.

  • Sutton, T. A., Hato, T., Mai, E., Yoshimoto, M., Kuehl, S., Anderson, M., Mang, H., Plotkin, Z., Chan, R. J., and Dagher, P. C. (2012) p53 Is Renoprotective after Ischemic Kidney Injury by Reducing Inflammation, J Am Soc Nephrol.

  • Tanaka, H., Abe, S., Huda, N., Tu, L., Beam, M. J., Grimes, B., and Gilley, D. (2012) Telomere fusions in early human breast carcinoma, Proc Natl Acad Sci U S A 109, 14098-14103.

  • Tao, W., Shi, J., Dorn, G. W., 2nd, Wei, L., and Rubart, M. (2012) Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Galphaq overexpression-induced pathological hypertrophy, J Mol Cell Cardiol 53, 409-419.

  • Vincentz, J. W., Rubart, M., and Firulli, A. B. (2012) Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease, Pediatr Cardiol 33, 923-928.

  • Vistbakka, J., Vanduyn, N., Wong, G., and Nass, R. (2012) C. elegansas a Genetic Model System to Identify Parkinson's Disease-associated Therapeutic Targets, CNS Neurol Disord Drug Targets.

  • Xi, Y., Ai, T., De Lange, E., Li, Z., Wu, G., Brunelli, L., Kyle, W. B., Turker, I., Cheng, J., Ackerman, M. J., Kimura, A., Weiss, J. N., Qu, Z., Kim, J. J., Faulkner, G., and Vatta, M. (2012) Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction, Circ Arrhythm Electrophysiol 5, 1017-1026.

  • Xu, Z., Christley, S., Lioi, J., Kim, O., Harvey, C., Sun, W., Rosen, E. D., and Alber, M. (2012) Multiscale model of fibrin accumulation on the blood clot surface and platelet dynamics, Methods Cell Biol 110, 367-388.

  • Zhang, W., Huang, Y., and Gunst, S. J. (2012) The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites, J Biol Chem 287, 33996-34008.

2011

  • Bailey, J. A., Maloney, B., Ge, Y. W., and Lahiri, D. K. (2011) Functional activity of the novel Alzheimer's amyloid beta-peptide interacting domain (AbetaID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis, Gene 488, 13-22.

  • Basile, D. P., Friedrich, J. L., Spahic, J., Knipe, N., Mang, H., Leonard, E. C., Changizi-Ashtiyani, S., Bacallao, R. L., Molitoris, B. A., and Sutton, T. A. (2011) Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury, Am J Physiol Renal Physiol 300, F721-733.

  • Basile, D. P., Zeng, P., Friedrich, J. L., Leonard, E. C., and Yoder, M. C. (2011) Low proliferative potential and anti angiogenic properties of cultured rat kidney endothelial cells, Angiogenesis - submitted

  • Basile, D. P., Zeng, P., Friedrich, J. L., and Yoder, M. C. (2011) Paradoxical pro-growth gene expression patterns in rat kidney endothelial cells characterized by limited growth potential J Am Soc Nephrol -Abstracts PO-2827, 2011.

  • Bergan, T. N., and Blount, M. A. (2011) Chronic use of Chloroquine Disrupts the Urine Concentration Mechanism by Lowering cAMP Levels in the Inner Medulla, AJP-Renal – in review.

  • Broxmeyer, H. E., Lee, M. R., Hangoc, G., Cooper, S., Prasain, N., Kim, Y. J., Mallett, C., Ye, Z., Witting, S., Cornetta, K., Cheng, L., and Yoder, M. C. (2011) Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood, Blood 117, 4773-4777.

  • Camirand, G., Li, Q., Demetris, A. J., Watkins, S. C., Shlomchik, W. D., Rothstein, D. M., and Lakkis, F. G. (2011) Multiphoton intravital microscopy of the transplanted mouse kidney, Am J Transplant 11, 2067-2074.

  • Camirand, G., Li, Q., Demetris, A. J., Watkins, S. C., Shlomchik, W. D., Rothstein, D. M., and Lakkis, F. G. (2011) Multiphoton intravital imaging of the transplanted mouse kidney, Am J Transplant 11, 2067-2074.

  • Chae, H. D., Lee, M. R., and Broxmeyer, H. E. (2011) AICAR Induces G1/S Arrest and Nanog Down-Regulation via p53 and Enhances Erythroid Differentiation, Stem Cells.

  • Chen, N. X., Moe, S. M., Eggleston-Gulyas, T., Chen, X., Hoffmeyer, W. D., Bacallao, R. L., Herbert, B. S., and Gattone, V. H., 2nd. (2011) Calcimimetics inhibit renal pathology in rodent nephronophthisis, Kidney Int 80, 612-619.

  • Clauss, M., Voswinckel, R., Rajashekhar, G., Sigua, N. L., Fehrenbach, H., Rush, N. I., Schweitzer, K. S., Yildirim, A. O., Kamocki, K., Fisher, A. J., Gu, Y., Safadi, B., Nikam, S., Hubbard, W. C., Tuder, R. M., Twigg, H. L., 3rd, Presson, R. G., Sethi, S., and Petrache, I. (2011) Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice, J Clin Invest 121, 2470-2479.

  • Clendenon, S. G., Young, P. A., Ferkowicz, M., Phillips, C., and Dunn, K. W. (2011) Deep tissue fluorescent imaging in scattering specimens using confocal microscopy, Microsc Microanal 17, 614-617.

  • Crabb, D. W., Zeng, Y., Liangpunsakul, S., Jones, R., and Considine, R. (2011) Ethanol impairs differentiation of human adipocyte stromal cells in culture, Alcohol Clin Exp Res 35, 1584-1592.

  • Dunn, K. W., Kamocka, M. M., and McDonald, J. H. (2011) A practical guide to evaluating colocalization in biological microscopy, Am J Physiol Cell Physiol 300, C723-742.

  • El-Achkar, T. M., McCracken, R., Rauchman, M., Heitmeier, M. R., Al-Aly, Z., Dagher, P. C., and Wu, X. R. (2011) Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism, Am J Physiol Renal Physiol 300, F999-1007.

  • Ferkowicz, M. J., and Yoder, M. C. (2011) Whole embryo imaging of hematopoietic cell emergence and migration, Methods Mol Biol 750, 143-155.

  • Hall, A. M., Crawford, C., Unwin, R. J., Duchen, M. R., and Peppiatt-Wildman, C. M. (2011) Multiphoton imaging of the functioning kidney, J Am Soc Nephrol 22, 1297-1304.

  • Huang, Y., Zhang, W., and Gunst, S. J. (2011) Activation of vinculin induced by cholinergic stimulation regulates contraction of tracheal smooth muscle tissue, J Biol Chem 286, 3630-3644.

  • Kalakeche, R., Hato, T., Rhodes, G., Dunn, K. W., El-Achkar, T. M., Plotkin, Z., Sandoval, R. M., and Dagher, P. C. (2011) Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment, J Am Soc Nephrol 22, 1505-1516.

  • Kepner, E. M., Yoder, S. M., Oh, E., Kalwat, M. A., Wang, Z., Quilliam, L. A., and Thurmond, D. C. (2011) Cool-1/betaPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion, Am J Physiol Endocrinol Metab 301, E1072-1080.

  • Kher, R., Sha, E. C., Escobar, M. R., Andreoli, E. M., Wang, P., Xu, W. M., Wandinger-Ness, A., and Bacallao, R. L. (2011) Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture, Am J Physiol Cell Physiol 301, C99-C105.

  • Kim, Y. J., Park, S. J., and Broxmeyer, H. E. (2011) Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction, J Immunol 187, 2291-2301.

  • Koehler, K. R., Tropel, P., Theile, J. W., Kondo, T., Cummins, T. R., Viville, S., and Hashino, E. (2011) Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells, BMC Neurosci 12, 82.

  • Lee, S. Y., Horbelt, M., Mang, H. E., Knipe, N. L., Bacallao, R. L., Sado, Y., and Sutton, T. A. (2011) MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury, Am J Physiol Renal Physiol 301, F101-109.

  • Li, D., Hallett, M. A., Zhu, W., Rubart, M., Liu, Y., Yang, Z., Chen, H., Haneline, L. S., Chan, R. J., Schwartz, R. J., Field, L. J., Atkinson, S. J., and Shou, W. (2011) Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis, Development 138, 303-315.

  • Li, D., Liu, Y., Maruyama, M., Zhu, W., Chen, H., Zhang, W., Reuter, S., Lin, S. F., Haneline, L. S., Field, L. J., Chen, P. S., and Shou, W. (2011) Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy, Hum Mol Genet 20, 4582-4596.

  • Liu, R. Y., Dong, Z., Liu, J., Yin, J. Y., Zhou, L., Wu, X., Yang, Y., Mo, W., Huang, W., Khoo, S. K., Chen, J., Petillo, D., Teh, B. T., Qian, C. N., and Zhang, J. T. (2011) Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma, Oncogene 30, 4814-4823.

  • Liu, Y., Ballman, K., Li, D., Khan, S., Derr-Yellin, E., Shou, W., and Haneline, L. S. (2011) Impaired function of Fanconi anemia type C-deficient macrophages, J Leukoc Biol.

  • Liu, Y., Lee, M. R., Timani, K., He, J. J., and Broxmeyer, H. E. (2011) Tip110 Maintains Expression of Pluripotent Factors in and Pluripotency of Human Embryonic Stem Cells, Stem Cells Dev.

  • Lorenz, K. S., Salama, P., Dunn, K. W., and Delp, E. J. (2011) Digital correction of motion artefacts in microscopy image sequences collected from living animals using rigid and nonrigid registration, J Microsc.

  • Molitoris, B. A. (2011) Disease-specific kidney imaging: introduction, Semin Nephrol 31, 235-236.

  • Molitoris, B. A., and Sandoval, R. M. (2011) Kidney endothelial dysfunction: ischemia, localized infections and sepsis, Contrib Nephrol 174, 108-118.

  • Molitoris, J. K., and Molitoris, B. A. (2011) Circulating micro-RNAs in acute kidney injury: early observations, Clin J Am Soc Nephrol 6, 1517-1519.

  • Ou, X., Chae, H. D., Wang, R. H., Shelley, W. C., Cooper, S., Taylor, T., Kim, Y. J., Deng, C. X., Yoder, M. C., and Broxmeyer, H. E. (2011) SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse, Blood 117, 440-450.

  • Park, S. J., Beck, B. D., Saadatzadeh, M. R., Haneline, L. S., Clapp, D. W., and Lee, S. H. (2011) Fanconi anemia D2 protein is an apoptotic target mediated by caspases, J Cell Biochem 112, 2383-2391.

  • Presson, R. G., Jr., Brown, M. B., Fisher, A. J., Sandoval, R. M., Dunn, K. W., Lorenz, K. S., Delp, E. J., Salama, P., Molitoris, B. A., and Petrache, I. (2011) Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact, Am J Pathol 179, 75-82.

  • Qu, P., Yan, C., Blum, J. S., Kapur, R., and Du, H. (2011) Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- mice, J Immunol 187, 3854-3866.

  • Rajashekhar, G., Gupta, A., Marin, A. J., Friedrich, J. L., Willuweit, A., Berg, D. T., Cramer, M. S., Sandusky, G. E., Sutton, T. A., Basile, D. P., Grinnell, B., and Clauss, M. (2011) Soluble Thrombomodulin Reduces Inflammation and Prevents Microalbuminuria Induced by Chronic Endothelial Activation in Transgenic Mice, Am J Physiol Renal Physiol.

  • Rajashekhar, G., Kamocka, M., Marin, A., Suckow, M. A., Wolter, W. R., Badve, S., Sanjeevaiah, A. R., Pumiglia, K., Rosen, E., and Clauss, M. (2011) Pro-inflammatory angiogenesis is mediated by p38 MAP kinase, J Cell Physiol 226, 800-808.

  • Saleh, M. A., Boesen, E. I., Pollock, J. S., Savin, V. J., and Pollock, D. M. Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes, Diabetologia 54, 979-988.

  • Saleh, M. A., Sandoval, R. M., Rhodes, G. J., Campos, S. B., Molitoris, B. A., and Pollock, D. M. (2011) Increased proximal tubular uptake prevents albuminuria in chronic endothelin-1-infused rats as determined by intravital 2-photon microscopy, Experimental Biology.

  • Sandoval, R. M., Wagner, M. C., Patel, M., Campos-Bilderback, S. B., Rhodes, G. J., Wang, E., Wean, S. E., Clendenon, S. C., and Molitoris, B. A. (2011 - in press) Fastingand genetics influence the albumin glomerular sieving coefficient in Munich Wistar rats, J Am Soc Nephrol.

  • Schweitzer, K. S., Johnstone, B. H., Garrison, J., Rush, N. I., Cooper, S., Traktuev, D. O., Feng, D., Adamowicz, J. J., Van Demark, M., Fisher, A. J., Kamocki, K., Brown, M. B., Presson, R. G., Jr., Broxmeyer, H. E., March, K. L., and Petrache, I. (2011) Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking, Am J Respir Crit Care Med 183, 215-225.

  • Vascotto, C., Bisetto, E., Li, M., Zeef, L. A., D'Ambrosio, C., Domenis, R., Comelli, M., Delneri, D., Scaloni, A., Altieri, F., Mavelli, I., Quadrifoglio, F., Kelley, M. R., and Tell, G. (2011) Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function, Mol Biol Cell 22, 3887-3901.

  • Vyas, P. M., Tomamichel, W. J., Pride, P. M., Babbey, C. M., Wang, Q., Mercier, J., Martin, E. M., and Payne, R. M. (2011) A TAT-Frataxin fusion protein increases lifespan and cardiac function in a conditional Friedreich's ataxia mouse model, Hum Mol Genet.

  • Ward, H. H., Romero, E., Welford, A., Pickett, G., Bacallao, R., Gattone, V. H., 2nd, Ness, S. A., Wandinger-Ness, A., and Roitbak, T. (2011) Adult human CD133/1(+) kidney cells isolated from papilla integrate into developing kidney tubules, Biochim Biophys Acta 1812, 1344-1357.

  • Wu, X., Chen, S., He, Y., Rhodes, S. D., Mohammad, K. S., Li, X., Yang, X., Jiang, L., Nalepa, G., Snider, P., Robling, A. G., Clapp, D. W., Conway, S. J., Guise, T. A., and Yang, F. C. (2011) The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1, PLoS One 6, e24917.

  • Xu, Z., Kamocka, M., Alber, M., and Rosen, E. D. (2011) Computational approaches to studying thrombus development, Arterioscler Thromb Vasc Biol 31, 500-505.

  • Yoshimoto, M., Montecino-Rodriguez, E., Ferkowicz, M. J., Porayette, P., Shelley, W. C., Conway, S. J., Dorshkind, K., and Yoder, M. C. (2011) Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential, Proc Natl Acad Sci U S A 108, 1468-1473.

  • Young, P. A., Clendenon, S. G., Byars, J. M., Decca, R. S., and Dunn, K. W. (2011) The effects of spherical aberration on multiphoton fluorescence excitation microscopy, J Microsc 242, 157-165.

  • Young, P. A., Clendenon, S. G., Byars, J. M., and Dunn, K. W. (2011) The effects of refractive index heterogeneity within kidney tissue on multiphoton fluorescence excitation microscopy, J Microsc 242, 148-156.

2010

  • Araki, S., Eitel, J. A., Batuello, C. N., Bijangi-Vishehsaraei, K., Xie, X. J., Danielpour, D., Pollok, K. E., Boothman, D. A., and Mayo, L. D. (2010) TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer, J Clin Invest 120, 290-302.

  • Babbey, C. M., Bacallao, R. L., and Dunn, K. W. (2010) Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells, Am J Physiol Renal Physiol 299, F495-506.

  • Chen, N. X., Chen, X., O'Neill, K. D., Atkinson, S. J., and Moe, S. M. (2010) RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates calcification in bovine vascular smooth muscle cells (BVSMC), Am J Physiol Renal Physiol 299, F674-680.

  • Chevalier, R. L., Forbes, M. S., and Thornhill, B. (2010) Proximal tubular injury and rapid foration of atubular glomeruli in adult mice with unilateral ureteral obstruction: A new look at an old model, ASN abstract number 2042.

  • Crotzer, V. L., Glosson, N., Zhou, D., Nishino, I., and Blum, J. S. (2010) LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens, Immunol