SCHOOL OF MEDICINE

Department of Medicine

Krannert Institute of Cardiology

Clinical Trials

The Krannert Institute of Cardiology has a rich history of basic science, translational, and clinical research in all aspects of cardiovascular medicine. Our physician-investigators believe not only in practicing evidence-based medicine, but also participating in clinical research that generates the evidence. Therefore, we are devoted to developing and improving the care of patients through innovative clinical research.  We are committed to serving our patients by integrating patient care, education and clinical research into our overall mission.

If you are a patient, sponsor, or potential collaborator and would like additional information, please contact our Clinical Research Manager:

Roxanne Kovacs, RN, MSN
(317) 274-0966
 
Clinical Research:
 

Electrophysiology Cardiology

Description:
The Krannert Institute is currently conducting clinical research studies to evaluate the safety and effectiveness of devices and ablation systems used to treat heart rhythm disturbances.

Potential Participants:
Adults with heart rhythm disturbances requiring pacemakers, defibrillators (ICD), or ablations.

Research Team:
Dr. John Miller
Dr. Deepak Bhakta
Dr. Mithilesh Das
Dr. Anil Yadav

For More Information, please contact:
Contact research coordinator:
Susan Straka - sstraka@iu.edu or (317) 274-0986

Echocardiography

Description:
The Krannert Institute is currently conducting clinical research studies to evaluating new techniques to evaluate heart function and to better predict outcomes, the correlation of cardiac stress testing to outcomes, alternative stress testing agents (e.g. Dopamine), prediction of sudden death and dysychrony by echocardiography, 3 D echo's ability to evaluate valvular heart disease, and outcomes of valvular heart disease using transthoracic echocardiography.

Potential Participants:
Adults with coronary or valvular disease or persons with possible cardiac disease.

Research Team:
Dr. Harvey Feigenbaum
Dr. Irmina Gradus-Pizlo
Dr. Stephen Sawada
Dr. Ronald Mastouri

For More Information:
Contact research coordinator:
Judy Foltz - jfoltz@iu.edu or (317) 274-0981

Interventional Cardiology

Description:
The Krannert Institute is currently conducting clinical research studies to evaluate the safety and effectiveness of various devices including cardiac stents and septal closure devices, as well as, comparative studies regarding revascularization treatment options for diabetics.

Potential Participants:
Adults with documented coronary artery disease who are scheduled to undergo a cardiac catheterization.

Research Team:
Dr. Jeffrey A. Breall
Dr. Islam Bolad
Dr. Anjan Sinha
Dr. Elisabeth von der Lohe
Dr. Rolf Kreutz
Dr. Ziad Jaradat

For More Information:
Contact research coordinator:
Judy Foltz - jfoltz@iu.edu or (317) 274-0981
 

Congestive Heart Failure

Description:
The Krannert Institute is currently conducting clinical research studies to evaluate the management of acute heart failure, the impact of anemia on chronic heart failure, mechanical device therapy (e.g. left ventricular assist devices (LVAD), biventricular pacemakers, and hemodynamic monitoring devices), psychosocial outcomes of specific treatments, and the impact of "heart failure clinic" on patient outcomes.

Potential Participants:
Adults with known congestive heart failure

Research Team:
Dr. Irmina Gradus-Pizlo
Dr. Masoor Kamalesh
Dr. M. Azam Hadi
Dr. Adnan Malik

For More Information:
Contact research coordinator:
Judy Foltz – jfoltz@iu.edu or (317) 274-0981

General Cardiology

Description:
The Krannert Institute is currently conducting clinical research studies to evaluate the safety and effectiveness of investigational and approved drugs for the treatment of acute coronary syndrome, patients with Non ST segment elevation acute coronary syndrome, as well as observing the incidence of heart abnormalities in patients with traumatic brain injury.

Potential Participants:
Adults presenting with acute coronary syndrome and those presenting with a traumatic brain injury.

Research Team:
Dr. Richard Kovacs
Dr. Ronald Mastouri
Dr. Masoor Kamalesh

For More Information:
Contact research coordinators:
Kim Smith – kimmsmit@iu.edu or (317) 274-0984
Keith Wright – kcwright@iu.edu or (317) 274-0983
 

Nuclear Cardiology

Description:
The Krannert Institute is currently conducting clinical research studies to evaluate outcomes of cardiac stress perfusion imaging in various clinical settings, the use of new stress techniques, and the correlation of stress perfusion patterns with other cardiac tests (e.g. EKG, catheterization, CT and MRI scans).

Potential Participants:
Adults with known heart disease

Research Team:
Dr. Stephen Sawada
Dr. Ronald Mastouri

For More Information:
Contact research coordinator:
Elise Hannemann – ehannema@iu.edu or (317) 274-0989

Vascular Cardiology

Description:
The Krannert Institute is currently evaluating the effects of exercise on circulating endothellial progenitor cells, angiogenisis factors in pericaridal fluid, pluripotent cell differentiation and vascular modulation, protein expression and function in atherosclerosis.

Potential Participants:
Adults undergoing an exercise stress test, adults with coronary artery disease, and adults with peripheral vascular disease.

Research Team:
Dr. Keith March

For More Information:
Contact research coordinators:
Pat G'Sell - pgsell@iu.edu or (317) 278-6585