SCHOOL OF MEDICINE

Department of Medicine

Nephrology

Transplant Nephrology Fellowship

The Transplant Nephrology Fellowship is a 1 Year Program and is accredited by the American Society of Transplantation (AST).

Our program is designed to produce qualified transplant nephrologists in all aspects of transplant medicine, which includes understanding and applying innovative immunosuppression regimens, as well as extending their research experience in the field of solid-organ transplantation.

Our 1-year and 3-year patient and graft survival of kidney transplant recipients are better than expected. The IU Health Physician Transplant Center's multidisciplinary kidney transplant team is comprised of many important staff members including skilled transplant surgeons, nurse coordinators, anesthesiologists and surgical team members, pharmacologists, nephrologists, interventional radiologists, pathologists, dietitians, social workers, psychologists, nursing staff, chaplains, administrative staff and financial counselors.

During the training, the fellow will primarily be located at Indiana University Hospital Organ Transplant Unit while also covering transplant related issues, if needed at the other clinical services of the Indiana University School of Medicine.

Applications

  • Transplant Nephrology fellowship applications are being accepted for the 2016-17 academic year starting July 1, 2015.
  • Please click here to download the application form
  • Applications are accepted via email to Joni Price at price21@iu.edu. Please submit all required material to this address.
  • Candidates for interview will be contacted directly by our office. Interviews will be conducted from August - October.
  • For additional kidney transplant information please visit the IU Health Kidney Transplant Specialties Area
 

Contact Information

Joni Price
Education Coordinator
Indiana University School of Medicine - Division of Nephrology
950 West Walnut Street, R2 202 - Indianapolis, IN 46202
☎ : (317) 278-6061
Fax: (317) 274-8575
Price21@iu.edu


Asif Sharfuddin, MD
Transplant Fellowship
Program Director
asharfud@iu.edu

IU Nephrology Transplant Physicians (l-r) Dr. Fisayo Adebiyi,
Dr. M. Sohail Yaqub, Dr. Timothy Taber,
Dr. Asif Sharfuddin and Dr. Dennis Mishler.

 

The basic educational goals for the transplant nephrology fellow include:

  • Managing minimum 30 new patients with kidney and/or KP transplant thoroughly and follow them for at least 3 months.
  • Observing 5 cadaveric, 5 living-donor kidney transplants and observing 3 organ harvests.
  • Doing minimum 30 pre-transplant recipient evaluations and 20 living donor evaluations.

The fellow will be involved in primary decision-making in all aspects of clinical care, including immunosuppression. During the training period, the fellow is extensively trained and becomes proficient in the following:

  • Managing acute and chronic transplant rejections.
  • Transplant related infectious diseases, such as BK Virus Nephropathy, CMV.
  • Transplant related malignancies such as PTLD, skin cancers.
  • Management of immunosuppressive regimens, cardiovascular disease, diabetes, hypertension, metabolic bone disease, anemia and chronic allograft nephropathy, in both inpatient and outpatient settings.

Comprehensive clinical experience is also acquired in managing patients with stable, as well as complicated courses, who have received kidney-pancreas transplants, liver transplants with renal complications and liver-kidney transplants. He/she will also be involved in teaching and guiding 1st year nephrology fellows.

Lectures will be provided by basic and clinical scientists on immunology, pharmacology, obstetrics, diabetes, metabolic bone disease and infectious disease topics to be included along with sessions on post operative and maintenance transplant care.

All year round, the fellow also attends an acute transplant clinic (once a week), chronic kidney and kidney/pancreas transplant clinic (once a week) and a pre-transplant donor and recipient evaluation clinic (alternate week).

The transplant fellow will share on-call with the rotating nephrology fellow. They will take calls from residents for any medical or renal problems. One faculty member will always be on call and available to guide them.

Approximately 150-200 transplant kidney biopsies are done every year at Indiana University Medical Center . Transplant fellows will alternate with the rotating nephrology fellow for the biopsies throughout the year to perform a minimum of 30 transplant biopsies. The transplant fellow is well experienced and can independently perform transplant kidney biopsies mid-way through their fellowship and generally performs approximately more than 35 biopsies during the training period.

The fellow is strongly encouraged to pursue clinical / translational research leading to at least one publication or national presentation. The Transplant Center is actively involved in research.

Examples of current active research include:

  • A phase III, randomized open-label, comparative, multi-center study to assess the safety and efficacy of Prograf® (tacrolimus)/MMF, modified release (MR) tacrolimus/MMF and Neoral® (cyclosporine)/MMF in de novo kidney transplant recipients.

  • Evaluation of immune globulin intravenous (human), 10 percent manufactured by chromatography process (IGIV-C, 10 percent), as an agent to reduce anti-HLA antibodies and improve transplantation results in cross-match positive living donor kidney allograft recipients.

Our Faculty and Fellows have recently published the following research:

Antibody Response Following Influenza Vaccination in Renal Transplant Recipients
M. Mujtaba, B. Book, A. Sharfuddin, A. Khalil, S. Vaishnav, E. Wiebke, M. Yaqub, D. Mishler, T. Taber.
Indiana University School of Medicne-IU Health, Indianapolis, IN.

Low Dose Valganciclovir Prophylaxis Following Renal Transplantation With Steroid Free Immunosuppression
J. Chen,1 A. Shah,2 M. Sauer,1 T. Taber,3 A. Sharfuddin,3 M. Yaqub,3 D. Mishler,3 J. Powelson,4 W. Goggins.4
1Pharmacy, IU Health, Indianapolis; 2Surgery, Thomas Jefferson University, Philadelphia; 3Nephrology, Indiana University School of Medicine, Indianapolis; 4Surgery, Indiana University School of Medicine, Indianapolis.

Preserved Kidney Volume in Living Kidney Donors: Correlation With 2 Year Renal Function Using CKD-EPI Equation to Predict Remaining GFR
Khalil,1 M. Yaqub,1 T. Taber,1 J. Powelson,1 C. Sundaram,1 W. Goggins,1 D. Mishler,1 M. Mujtaba,1 A. Diez,2 A. Sharfuddin.1
1Indiana University; 2Ohio State University, Columbus.

Kidney Transplant Outcomes in Recipients Older Than 70: A Single Center Experience
M. Yaqub, A. Sharfuddin, M. Mujtaba, D. Mishler, T. Taber, W. Goggins, N. Kassis Akl.
Indiana University Health, Indianapolis, IN.

Living Donor Gifted Lithiasis: Outcomes in Kidney Transplant Recipients
M. Mujtaba, C. Sundaram, M. Yaqub, T. Taber, J. Powelson, S. Doshi, A. Sharfuddin.
Indiana University, Indianapolis.

Treatment of Hepatitis C Virus in Kidney Transplant Recipients With Direct Acting Anti-Viral Agents: Early Results in 12 Cases
Sharfuddin,1 T. Taber,1 M. Mujtaba,1 M. Yaqub,1 D. Mishler,1 P. Kwo,2 R. Vuppalanchi.2
1Medicine/Nephrology, Indiana University, Indianapolis; 2Medicine/Hepatology, Indiana University, Indianapolis.

Pre-Transplant Angiotensin Receptor II Type 1 Antibodies (AT1R) and Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) as Predictors of Post Transpalnt FSGS Recurrence
Khalil, T. Tim, A. Sharfuddin, S. Doshi, M. Yaqub, D. Mishler, W. Goggins, M. Mujtaba.
Indiana University school of Medicine-IU Health Transplant, Indianapolis, IN.

Renal Outcomes of Cross Match Positive Simultaneous Liver Kidney (SLK) Transplant Recipients Compared to Cross Match Positive Kidney Allograft Recipients
S. Vaishnav,1 T. Taber,1 W. Goggins,2 S. Nagaraju,2 J. Fridell,2 A. Sharfuddin,1 M. Yaqub,1 D. Mishler,1 M. Mujtaba.1
1IUSM, IU Health, Indianapolis, IN; 2Surgery, Transplant, Indiana University School of Medicine, Indianapolis, IN.

Pancreas Transplantation Immunosuppression Induction With Rabbit Antithymocyte Globulin +/- Rituximab and Early Steroid Withdrawal: Experience With >500 Recipients
J. Fridell,1 R. Mangus,1 J. Chen,2 M. Mujtaba,3 T. Taber,3 M. Goble,1 J. Powelson.1
1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Pharmacy, Indiana University School of Medicine, Indianapolis, IN; 3Medicine, Indiana University School of Medicine, Indianapolis, IN.

10 Year Experience Using a Steroid Free Three Drug Maintenance Immunosuppression Regimen for Pancreas Transplant Alone: Comparison of Induction With Rabbit Antithymocyte Globulin +/- Rituximab
J. Fridell,1 R. Mangus,1 J. Chen,2 M. Mujtaba,3 T. Taber,3 M. Goble,1 J. Powelson.1
1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Pharmacy, Indiana University School of Medicine, Indianapolis, IN; 3Medicine, Indiana University School of Medicine, Indianapolis, IN.

2015 Abstracts

Living Donor Gifted Lithiasis: Outcomes in Kidney Transplant Recipients. Muhammad Mujtaba1, Chandru Sundaram1, Muhammad Yaqub1, Tim Taber1, John Powelson1, Simit Doshi1 and Asif Sharfuddin1. 1Indiana University, Indianapolis, United States. Presented at ATC 2015 Philadelphia.

 

Preserved Kidney Volume in Living Kidney Donors: Correlation with 2 year renal function using CKD-EPI equation to predict remaining GFR. Ali Khalil1, Muhammad Yaqub1, Tim Taber1, John Powelson1, Chandru Sundaram1, William Goggins1, Dennis P Mishler1, Muhammad Mujtaba1, Alejandro Diez2 and Asif Sharfuddin1. 1Indiana, University, United States and 2Ohio State University, Columbus, United States. Presented at ATC 2015 Philadelphia.

 

Treatment of Hepatitis C Virus in Kidney Transplant Recipients With Direct Acting Anti-Viral Agents: Early Results in 12 Cases”. Asif Sharfuddin, Tim Taber, M Yaqub, M Mujtaba, Paul Kwo, Raj Vuppulanchi. Presented at ATC 2015 Philadelphia. (LATE BREAKING ORAL PRESENTATION)

 

Living Donor Remaining Function Measured by CKD-EPI Correlates with Remaining Kidney Volume. Asif A. Sharfuddin, MD, FASN, Ali Khalil, MD, Muhammad S. Yaqub, MD, FASN, Tim E. Taber, MD, Muhammad Ahmad Mujtaba, MBBS, MD, FASN – Presented at ASN 2015, San Diego.

 

Kidney Transplant Outcomes for Patients with Amyloidosis – A United Network for Organ Sharing Database Analysis.  Ali Khalil, MD, Tim E. Taber, MD, Muhammad Ahmad Mujtaba, MBBS, MD, FASN, Muhammad S. Yaqub, MD, FASN, Asif A. Sharfuddin, MD, FASN. Presented at ASN 2015, San Diego.

2015 Publications

Native Nephrectomy with Renal Transplantation is Associated with a Decrease in Hypertension Medication Requirements in Autosomal Dominant Polycystic Kidney Disease. Shumate AM, Bahler CD, Goggins WC, Sharfuddin AA, Sundaram CP. J Urol. 2015 Aug 28. pii: S0022-5347(15)04682-0. doi: 10.1016/j.juro.2015.07.114.

Native Nephrectomy with Renal Transplantation is Associated with a Decrease in Hypertension Medication Requirements in Autosomal Dominant Polycystic Kidney Disease. Shumate AM, Bahler CD, Goggins WC, Sharfuddin AA, Sundaram CP. J Urol. 2015 Aug 28. pii: S0022-5347(15)04682-0. doi: 10.1016/j.juro.2015.07.114.

Early Fatal Cutaneous Lower Extremity Angiosarcoma Associated with Deep Venous Thrombosis in a Renal Transplant Recipient. Sher SJ, Mujtaba MA, Yaqub MS, Taber TE, Mishler DP, Sharfuddin AA. Exp Clin Transplant. 2015 Jul 2. doi: 10.6002/ect.2014.0289.

Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis. Ali A, Mishler D, Taber T, Agarwal D, Yaqub M, Mujtaba M, Goggins W, Sharfuddin A. Clin Transplant. 2015 Sep;29(9):747-55. doi: 10.1111/ctr.12574. Epub 2015 Jul 14.

Pre-transplant angiotensin receptor II type 1 antibodies and risk of post-transplant focal segmental glomerulosclerosis recurrence. Mujtaba MA, Sharfuddin AA, Book BL, Goggins WC, Khalil AA, Mishler DP, Fridell JA, Yaqub MS, Taber TE. Clin Transplant. 2015 Jul;29(7):606-11. doi: 10.1111/ctr.12562. Epub 2015 Jul 4.

2016 Abstracts

Steroid Free Immunosuppression and Clinical Outcomes in Recipients of Deceased Donor Kidney Transplant with Positive Flow Cytometry Crossmatch. O. Adebiyi, T. Taber, W. Goggins, D. Mishler, M. Yaqub, A. Sharfuddin. Indiana University, Indianapolis. ATC 2016 Boston

Concordance Between Pancreatic Rejection and Kidney Rejection and Kidney Survival in Simultaneous Pancreas Kidney Transplantation. I. Moinuddin, T. Taber, M. Yaqub, D. Mishler, O. Adebiyi, J. Chen, M. Goble, J. Powelson, J. Fridell, A. Sharfuddin. ATC 2016 Boston

The Impact of One Year Individual or Dual Organ Rejection in Simultaneous Pancreas-Kidney Transplant on Kidney Graft Survival – A UNOS Registry Analysis 2000-2013. I. Moinuddin,1 T. Taber,1 M. Yaqub,1 O. Adebiyi,1 M. Mujtaba,1 J. Chen,2 M. Goble,2 D. Mishler,1 J. Fridell,2 A. Sharfuddin. ATC 2016 Boston. (ORAL)

Conversion from Tacrolimus to Belatacept in Pancreas Transplant Alone Recipients with Chronic Kidney Disease. A. Sharfuddin, J. Chen, M. Yaqub, T. Taber, J. Powelson, D. Mishler, M. Goble, J. Fridell, O. Adebiyi, M. Mujtaba. (ORAL)

Graft Versus Host Disease (GVHD) in Patients with Pancreas Transplant Alone (PTA). M. Mujtaba,1 A. Sharfuddin,2 A. Khalil,2 T. Taber,2 M. Goble,2 J. Powelson,2 J. Fridell.

Kidney Survival Outcomes in Combined Intestinal-Kidney Transplant: An Analysis of the UNOS/OPTN Database 2000-2014. A. Sharfuddin, T. Taber, M. Yaqub, I. Moinuddin, A. Khalil, O. Adebiyi, M. Mujtaba.

2016 Publications

Guillain-Barré syndrome associated with resistant cytomegalovirus infection after face transplantation. Alhefzi M, Aycart MA, Bueno EM, Kueckelhaus M, Fischer S, Snook RJ, Sharfuddin AA, Hadad I, Malla P, Amato AA, Pomahac B, Marty FM. Transpl Infect Dis. 2016 Apr;18(2):288-292. doi: 10.1111/tid.12516.

 

Re-transplants compared to primary kidney transplants recipients: a mate kidney paired analysis of the OPTN/UNOS database. Khalil AK, Slaven JE, Mujtaba MA, Yaqub MS, Mishler DP, Taber TE, Sharfuddin AA.  Clin Transplant. 2016 May;30(5):566-78. doi: 10.1111/ctr.12722. Epub 2016 Mar 30.

 

Outcomes of Hepatitis C-Positive Kidney Transplant Recipients Compared With Hepatitis C-Negative Recipients in Today's Era of Immunosuppression: A UNOS Database Analysis With Long-Term Follow-Up. Khalil A, Mujtaba MA, Aljanabi OT, Ghabril MS, Taber TE, Yaqub MS, Sharfuddin A.  Exp Clin Transplant. 2016 Jun 15. doi: 10.6002/ect.2015.0296. [Epub ahead of print]

 

Trends and outcomes in right vs. left living donor nephrectomy: an analysis of the OPTN/UNOS database of donor and recipient outcomes - should we be doing more right-sided nephrectomies? Khalil A, Mujtaba MA, Taber TE, Yaqub MS, Goggins W, Powelson J, Sundaram C, Sharfuddin AA.Clin Transplant. 2016 Feb;30(2):145-53. doi: 10.1111/ctr.12668. Epub 2015 Dec 28.

 

Deceased donor organ procurement injuries in the United States. Taber TE, Neidlinger NA, Mujtaba MA, Eidbo EE, Cauwels RL, Hannan EM, Miller JR, Paramesh AS.  World J Transplant. 2016 Jun 24;6(2):423-8. doi: 10.5500/wjt.v6.i2.423.

 

Effect of Treatment With Tabalumab, a B Cell-Activating Factor Inhibitor, on Highly Sensitized Patients With End-Stage Renal Disease Awaiting Transplantation. Mujtaba MA, Komocsar WJ, Nantz E, Samaniego MD, Henson SL, Hague JA, Lobashevsky AL, Higgins NG, Czader M, Book BK, Anderson MD, Pescovitz MD, Taber TE. Am J Transplant. 2016 Apr;16(4):1266-75. doi: 10.1111/ajt.13557. Epub 2016 Jan 18.

 

Clinical Significance of Pre-Transplant Donor Specific Antibodies in the Setting of Negative Cell-Based Flow Cytometry Crossmatching in Kidney Transplant Recipients.  Adebiyi OO, Gralla J, Klem P, Freed B, Davis S, Wiseman A, Cooper JE.  Am J Transplant. 2016 May 3. doi: 10.1111/ajt.13848. [Epub ahead of print]

 

Book Chapters

Imaging Evaluation of Kidney Transplant Recipients. Seminars in Nephrology . Asif Sharfuddin– Nov 2010. Online May 2011

Acute Kidney Injury: Pathophysiologic Aspects. Sharfuddin AA & Molitoris BA. In “The Kidney: Physiology & Pathophysiology, 5th Edition”. Edited by Alpern & Hebert, Published by Elsevier/Academic Press. Submitted Dec  2011. Published Oct 2012.

Acute Kidney Injury. Brenner and Rectors: The Kidney , 10th Edition – in Press – Submitted Jun 2014.  Published Nov 2015.

Renal Imaging – Scientific American NDT – Irfan Moinuddin, Tariq Hameed, Asif Sharfuddin . Submitted Jan 2016. To Be Published Nov 2016.

Successful completion of the fellowship should ensure that you meet criteria set forth by UNOS for designation as a renal transplant physician and a pancreas transplant physician as well as be eligible to become medical director of a kidney transplant program.

Benefits for the Transplant Nephrology Fellowship

  • Four weeks of vacation per year, with additional time off for the annual AST conference.
  • Medical insurance for you and your dependents at no cost to you.
 

To see additional benefits, click here