Department of Medicine

Indiana Center for AIDS Research

Researchers & Faculty

Executive Committee
Samir Gupta, MD
Director, Indiana Center for AIDS Research
Associate Professor of Medicine
Division of Infectious Diseases
Emerson Hall, Room 421
545 N. Barnhill Dr.
Indianapolis, IN 46202
Phone: 317-274-7926
Fax: 317-274-1587

Research Description

Dr. Gupta conducts clinical and translational research in new HIV treatment strategies and methods to reduce chronic co-morbidities in HIV-infected persons. He currently holds NIH grants focused on depression treatment to reduce systemic inflammation and improve cardiovascular risk and also on the role of inflammatory monocytes on endothelial colony forming cells. He also supports the research of other groups by performing in vivo vascular imaging and providing clinical samples from HIV-infected patients within the IU Health medical system.

Rachel Vreeman, MD, MS
Director of HIV Global Health Research, Indiana CFAR
Associate Professor of Medicine
Department of Pediatrics

Research Description

Dr. Vreeman’s research focuses on improving the provision of long-term HIV care to children within resource-limited settings, focusing on supporting children’s adherence to HIV therapy, disclosure of HIV status, addressing HIV-related stigma, and improving pediatric antiretroviral therapy formulations for children and adolescents.

Dr. Vreeman plays a global leadership role in the care of HIV-infected children and adolescents. She chairs the Pediatric Working Group for the global IeDEA (International Epidemiologic Databases Evaluating AIDS) consortium, a global consortium of HIV care programs funded by the National Institutes of Health. She is also a leader on the cohort collaborations for the International AIDS Society’s Collaborative Initiative for Pediatric HIV Education and Research (CIPHER). In addition, she serves on the NIH study section on Behavioral and Social Consequences of HIV.


Dennis Fortenberry, MD, MS
Professor of Pediatrics and Medicine
Department of Pediatrics

Research Description

Dr. Fortenberry has long been involved in novel research and programs directed at improving the lives of adolescents with sexually transmitted infections, including HIV. He currently is working to better engage at-risk youth in the HIV Continuum of Care as a means to improve the lives of ouryoungest patients as wells as to reduce ongoing HIV transmission in this population.


Homer Twigg III, MD
Director of the Basic Science Core, Indiana CFAR
Professor of Medicine
Department of Pulmonary, Allergy, Critical Care and Sleep Medicine

Research Description

Dr. Twigg has a long research interest in pulmonary host defense in HIV infection and has served on many special emphasis panels sponsored by the NHLBI in this area. Most recently Dr. Twigg has been investigating the lung Microbiome in healthy subjects and patients with HIV infection. He currently is a standing member of the Lung Cellular, Molecular, and Immunobiology (LCMI) study section.



Qigui (Andy) Yu, MD, PhD
Associate Director of the Basic Science Core, Indiana CFAR
Associate Professor
Department of Microbiology and Immunology

Research Description

Dr. Yu's research mainly focuses on the immunopathogenesis of HIV infection and the clinical and immunological interactions between HIV and other human persistent viruses like HCV. He is currently leading research funded by the NIH and the Bill & Melinda Gates Foundation focusing on understanding the mechanisms underlying HIV latency and persistence, eradication of HIV reservoirs, novel strategies for the design of HIV vaccines, and the pathogenic mechanisms underlying the accelerated liver disease observed in HCV/HIV co-infected individuals. He has also developed a highly collaborative and translational research program at IUSM where he interacts with many clinicians and basic scientists. 



Bree Weaver, MD
Director of Community Engagement, Indiana CFAR
Assistant Professor of Clinical Medicine and Clinical Pediatrics
Division of Infectious Diseases

Research Description

Dr. Weaver provides clinical care for adults and children living with HIV in the IU Health and Eskenazi Health medical systems. She conducts clinical research in new HIV treatment strategies, including clinical trials of new antiretroviral medications. She supports research of other investigators in her role as Medical Director of the Eskenazi Infectious Diseases Clinic. Her other clinical and research interests include programs to increase routine HIV screening in community health centers, early linkage to clinical care, and prevention of HIV and STIs among adolescents.



Jaroslaw Harezlak, PhD
Director of Biostatistics, Indiana CFAR
Associate Professor of Medicine
Department of Biostatistics

Research Description

Dr. Harezlak conducts quantitative research in complex and high-dimensional data settings. His HIV-related investigations concern discovering early biomarkers of neurocognitive impairment (NCI) of chronically HIV-infected individuals. He is currently leading research funded by an NIH grant focusing on developing statistical methods for discovery of multi-modal brain imaging signatures of NCI progression. He also collaborates on a grant studying structural longitudinal changes in the HIV-infected subjects’ brains.



Kara Wools-Kaloustian, MD
Director of Developmental, Indiana CFAR
Professor of Medicine
Department of Infectious Diseases

Research Description

Dr. Wools-Kaloustian is the Co-PI of the International Epidemiologic Databases to Evaluate AIDS (IeDEA) East Africa Consortium. The majority of her research has been related to assessing the outcomes of antiretroviral rollout in sub-Saharan Africa this has included assessing the risk of renal disease in HIV-infected Kenyan patients, outcomes of patients enrolled in care, task-shifting models within HIV care programs as well as evaluating the integration of prevention of mother to child transmission of HIV (pMTCT) interventions into HIV-care and treatment programs. East African IeDEA is one of 7 regional consortiums that have been constituted to explore the epidemiology of HIV-treatment implementation globally. For the East African Region this has included assessing the trends in CD4 count at the start of antiretroviral therapy (ART), outcomes of pMTCT, issues related to loss to follow-up (LTFU), incidence of Kaposi’s sarcoma in the ART-era, the natural history of perinatally acquired HIV infection in the ART era, the impact of alcohol on retention and assessment of cervical cancer screening integration into HIV-treatment programs.