Peer-reviewed Literature References (CYP2B6)
2B6 SUBSTRATES:BUPROPIONValidation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. [ PMID 10997944 ] Faucette SR, Hawke RL, Lecluyse EL, Shord SS, Yan B, Laethem RM, Lindley CM. Drug Metab Dispos 2000 Oct;28(10):1222-30 CYCLOPHOSPHAMIDE Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. [ PMID 8242617 ] Chang TK, Weber GF, Crespi CL, Waxman DJ Cancer Res 1993 Dec 1;53(23):5629-37. EFAVIRENZ Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation. [ PMID 18728241 ] Kwara A, Lartey M, Sagoe KW, Xexemeku F, Kenu E, Oliver-Commey J, Boima V, Sagoe A, Boamah I, Greenblatt DJ, Court MH. J Clin Pharmacol. 2008 Sep;48(9):1032-40. High prevalence of the CYP2B6 516G-->T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe. [ PMID 18057928 ] Nyakutira C, Röshammar D, Chigutsa E, Chonzi P, Ashton M, Nhachi C, Masimirembwa C. Eur J Clin Pharmacol. 2008 Apr;64(4):357-65. IFOSPHAMIDE Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. [ PMID 8242617 ] Chang TK, Weber GF, Crespi CL, Waxman DJ Cancer Res 1993 Dec 1;53(23):5629-37. Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. [ PMID 10101149 ] Granvil CP, Madan A, Sharkawi M, Parkinson A, Wainer IW Drug Metab Dispos 1999 Apr;27(4):533-41. METHADONE Role of CYP2B6 in stereoselective human methadone metabolism. [ PMID 18292673 ] Totah RA, Sheffels P, Roberts T, Whittington D, Thummel K, Kharasch ED. Anesthesiology. 2008 Mar;108(3):363-74. SORAFENIB Prescribing Information 2B6 INHIBITORS:THIOTEPATriethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism. [ PMID 11950782 ] Rae JM, Soukhova NV, Flockhart DA, Desta Z. Drug Metab Dispos 2002;30(5) TICLOPIDINE Mechanism-based inhibition of human cytochrome P450 2B6 by ticlopidine, clopidogrel, and the thiolactone metabolite of prasugrel. [ PMID 19047469 ] Nishiya Y, Hagihara K, Ito T, Tajima M, Miura SI, Kurihara A, Farid NA, Ikeda T. Drug Metab Dispos. 2008 Dec 1. 2B6 INDUCERS:PHENOBARBITALEnhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. [ PMID 9157990 ] Chang TK, Yu L, Maurel P, Waxman DJ Cancer Res 1997 May 15;57(10):1946-54 PHENYTOIN Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers. [ PMID 9332469 ] Ducharme MP, Bernstein ML, Granvil CP, Gehrcke B, Wainer IW Cancer Res 1997 May 15;40(6):531-3 RIFAMPIN Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. [ PMID 9157990 ] Chang TK, Yu L, Maurel P, Waxman DJ Cancer Res 1997 May 15;57(10):1946-54 |
