Clinical Pharmacokinetics
| Topic | Lecturer |
| Introduction; scope of course; introduction to "model independent" pharmacokinetics Non-compartmental pharmacokinetics analysis; statistical moment analysis, rate processes, graphical analysis, renal clearance | Bergstrom, Hall, Gorski, Satterwhite Latz, Schneck |
| Linear compartment models, One-compartment model (IV bolus, infusions, oral administration), Curve stripping exponentials | Bergstrom, Gorski, Zhang, Ni, Musib |
| Linear compartment models, Two-compartment model (IV bolus, infusions, oral administration), polyexponential equations - relationship to compartmental models; Multi-compartment models (IV and oral) | Bergstrom, Gorski, Zhang, Ni, Musib |
| Multiple dosing, prediction/simulation of single and multiple dose, superposition, dose proportionality, volume of distribution, protein binding | Bergstrom, Musib, Kothare Chaudhary, Gorski |
| Clearance concepts, first-pass metabolism, protein binding, entero-hepatic recirculation, physiologic models, effect of physiologic processes on pharmacokinetics | Hall, Gorski |
| Nonlinear pharmacokinetic principles, Michaelis-Menten Kinetics, zero-order kinetics, Time Dependent Pharmacokinetics | Abu-Raddad, Suri, Lobo, Small |
| Pharmacodynamics; Principles of Drug Action; modeling drug action, biomarkers | Forgue, Jin, Satterwhite |
| Bioavailability/Bioequivalence Absorption kinetics, sustained release, statistical concepts for BA/BE, Historical Aspects of BE assessment (75/75 and Individual Bioequivalence, Replicate Study Design) Biopharmaceutics Classification System | Witcher, de la Peña, Bergstrom, Skrivanek |
| Introduction to population pharmacokinetic modeling and Bayesian forecasting | Heathman, Sinha, Latz, Chien |
| PK/PD variability, special populations, pediatrics, elderly, effect of age, weight, disease on pharmacokinetics; Therapeutic and Clinical PK Applications: Therapeutic Drug Monitoring | Satterwhite, Latz Wrishko, Schneck |
| Study Design: Theoretical and Practical Aspects, Optimal sampling | Freidrich, Park, Heathman |
| Pharmacogenetics in pharmacokinetics Cytochrome P450: In vitro drug metabolism | Callaghan, Wrighton, Flockhart, Gorski |
| Metabolism and metabolite kinetics: Phase 1 and 2 enzymes; PK of biotechnology products, antibodies, and endogenous substances | Kielbasa, Kothare, de la Peña, Hansen |
| Drug Interactions, In vivo and in vitro methods and strategies for evaluating drug interactions | Desta, Gorski, Chien |
