SCHOOL OF MEDICINE

Department of Medicine

Clinical Pharmacology

Friday Journal Club (2014)

 

Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.


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Date Presenter Journal Title

17-Jan

Nieves Velez de Mendizabal, Josiane Cardoso, Tyler Shugg (L)

n engl j med 369;24
A Randomized Trial of Genotype-Guided Dosing of Warfarin

24-Jan

Rich Bergstrom, Costantine Albany, Tonia Gardner (L)

doi: 10.1111/bcp.12322 Influence of covariate distribution on the predictive performance of pharmacokinetic models in paediatric research

31-Jan

Sarah Quinney, Claire Li, Christina Chung (L) J Antimicrob Chemother 2014; 69: 180–189 doi:10.1093/jac/dkt304 Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis

07-Feb

Michael Eadon, Kimberly Burgess, Heqiao Dai (L)

HEPATOLOGY 2013;58:1918-1929 Once-Daily Simeprevir (TMC435) With Pegylated Interferon and Ribavirin in Treatment-Na€ıve Genotype 1 Hepatitis C: The Randomized PILLAR Study  

14-Feb

Beth Pflug, Anna Schwartz, Nadia Falah (L)

Sci Transl Med 6, 221ra15 (2014) Antioxidants Accelerate Lung Cancer Progression in Mice

21-Feb

David Thacker Bies, Nadia Falah, Noha Mourad (L)

Circ Cardiovasc Genet. 2013;6:313-316 Arrhythmia Risk in Long QT Syndrome Beyond the Disease-Causative Mutation

21-Feb

Supplemental material

Circ Cardiovasc Genet. 2013;6:354-361 Identification of a KCNQ1 Polymorphism Acting as a Protective Modifier Against Arrhythmic Risk in Long-QT Syndrome

28-Feb

Rolf Kreutz, Kruti Joshi, Heng Zhao (L)

N Engl J Med 2013;369:1206-14 Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

07-Mar

Tom Callaghan, Deshun Lu, Mike Ferguson (L)

J Clin Oncol 31:4562-4568 Evaluating Many Treatments and Biomarkers in Oncology: A New Design

14-Mar

David Foster, Ayman Akil, Eric Benson (L)

Drug Metab Dispos 41:1514–1521 In Vivo Assessment of the Impact of Efflux Transporter on Oral Drug Absorption Using Portal Vein–Cannulated Rats

21-Mar

No Journal Club - ASCPT

   

28-Mar

No Journal Club- 4th Year Course

   

4-Apr

Lang Li, Rebecca Pierson, Jinzhong Liu (L)

Cell 149, 780–794, May 11, 2012 Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks;

11-Apr

Brian Decker, Elizabeth Sierra Potchanant, Costantine Albany (L)

British Journal of Cancer (2014), 1–8 | doi: 10.1038/bjc.2014.128
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives

18-Apr

Zeruesenay Desta, Abhishek Gulati, Josiane Cardoso (L)

doi:10.1038/clpt.2013.241 Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects

25-Apr

David Flockhart, Smitha Marri, Deshun Lu (L)

doi:10.1038/clpt.2013.210 Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance

02-May

Jamie Renbarger, Ingrid Ferreira Metzger, Noha Moroud (L)

Journal of the American College of Cardiology Vol. 62, No. 23, 2013 Mipomersen, an Apolipoprotein B Synthesis Inhibitor, Reduces Atherogenic Lipoproteins in Patients With Severe Hypercholesterolemia at High Cardiovascular Risk

09-May

Todd Skaar, Tyler Shugg, Kruti Joshi (L)

DOI: 10.1097/FTD.0000000000000080 CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients

16-May

David Haas, Christina Chung, Anna Schwartz (L)

Antimicrob. Agents Chemother. 2014, 58(5):2830. DOI:10.1128/AAC.01718-13. Determination of Vancomycin Pharmacokinetics in Neonates To Develop Practical Initial Dosing Recommendations

23-May

Avi Patil, Mike Ferguson, Ayman Akil (L)

PLoS ONE 8(9): e74404. doi:10.1371, September 2013 | Volume 8 | Issue 9 | e74404 Multicompartmental Pharmacokinetic Model of Tenofovir Delivery by a Vaginal Gel

30-May

No Journal Club

   

06-Jun

David Jones, Nadia Falah, Rebecca Pierson (L)

JAMA Pediatr. doi:10.1001/jamapediatrics.2013.4914 Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders

13-Jun

Ken Levy, Jinzhong Liu, Kimberly Burgess (L)

N Engl J Med 2013;368:1685-94 DOI: 10.1056/NEJMoa1209026 Treatment of HCV Infection by Targeting MicroRNA  

20-Jun

Rob Bies, Heqaio Dai, Abhishek Gulati (L)

J Thromb Haemost 2014; 12: 902–9.DOI: 10.1111/jth.12564 No effect of isolated long-term supine immobilization or profound prolonged hypoxia on blood coagulation

27-Jun

Brian Overholser, Tonia Gardner, Eric Benson (L)

Clinica l pharmac ology & Therapeut ics | VOLUME 95 NUMBER 4 | april 2014 doi:10.1038/clpt.2013.229 Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing

18-July

Sara Quinney, Josiane Cardoso, Smitha Marri (L)

CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 96 NUMBER 1 | JULY 2014, doi:10.1038/clpt.2014.63 Sorafenib Dose Escalation Is Not Uniformly Associated With Blood Pressure Elevations in Normotensive Patients With Advanced Malignancies

25-July

Tom Callaghan, Ayman Akil, Ingrid Ferreira Metzger (L)

NATURE COMMUNICATIONS 4 May 2013 | Accepted 27 Mar 2014 | Published 6 May 2014; DOI: 10.1038/ncomms4739 High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening

1-Aug

Michael Eadon, Anna Schwartz, Christina Chung (L)

Clinical pharmacology & Therapeutics: doi:10.1038/clpt.2014.131 Pulmonary Penetration of Piperacillin and Tazobactam in Critically Ill Patients

8-Aug

Rich Bergstrom, Noha Mourad, Heng Zhao (L)

TR-05530; doi:/10.1016/j.thromres.2014.05.019 The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study

15-Aug

Beth Pflug, Elizabeth Sierra Potchanant, Tyler Shugg (L)

The Journal of Clinical Pharmacology 54(8) 896–900© 2014, The American College of Clinical Pharmacology; DOI: 10.1002/jcph.332 Identification of VKORC1 Genotype Leading to Resistance to Tecarfarin

22-Aug

Rob Bies, Rebecca Pierson, Kimberly Burgess (L)

Blood First Edition Paper, prepublished online May 14, 2014; DOI 10.1182/blood-2014-01-552166 Adherence to oral 6-mercaptopurine in African American and Asian children with acute lymphoblastic leukemia: a Children’s Oncology Group study

29-Aug

David Flockhart, Jacob Zucker, Jinzhong Liu (L)

J Pharmacokinet Pharmacodyn; DOI 10.1007/s10928-012-9271-3 Modeling of Functional Assessment Questionnaire (FAQ) as continuous bounded data from the ADNI database

5-Sept

Costantine Albany, Abhishek Gulati, Anna Schwartz (L)

Anesthesiology, V XXX • No XXX; doi;10.1097/ALN.0000000000000391 Cyclosporine-inhibitable Cerebral Drug Transport Does Not Influence Clinical Methadone Pharmacodynamics

12- Sept

Zeruesenay Desta, Mustafa Hyder, Josiane Cardoso (L)

Clinical Pharmacology & Therapeutics; doi10.1038/clpt.2014.141 Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

19-Sept

Lang Li, Ingrid Ferreira Metzger, Ayman Akil (L)

BMJ Open 2013;3:e001844. doi:10.1136/bmjopen-2012-001844 A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4inhibitors, sitagliptin and linagliptin, in treatment of type 2 diabetes mellitus

26-Sept

No Journal Club - CTSI Annual Meeting

   

3-Oct

David Foster, Tyler Shugg, Christina Chung (L)

Antimicrob. Agents Chemother. 2014, 58(7):3744. DOI: 10.1128/AAC.02089-13 Population Pharmacokinetic Analysis of Piperacillin in Burn Patients

10-Oct

Jamie Renbarger, Deshun Lu, Rebecca Pierson (L)

Pharmacogenetics and Genomics 24:348–355; DOI: 10.1097/FPC.0000000000000061 Cancer patients’ acceptance, understanding, and willingness-to-pay for pharmacogenomic testing

17-Oct

Todd Skaar, Noha Mourad, Jacob Zucker (L)

NATURE VOLUME 95 NUMBER 6 JUNE 2014; doi: 10.1038/clpt.2014.37 Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients

24-Oct

No Journal Club - Gladstein Lecture

   

31--Oct

Avi Patil, Ayman Akil, Mustafa Hyder (L)

J Clin Oncol 32:1317-1323. © 2014 by American Society of Clinical Oncology; DOI: 10.1200/JCO.2013.52.4298 Physicians’ Attitudes About Multiplex Tumor Genomic Testing

7-Nov

Jim Tisdale, Kimberly Burgess, Deshun Lu (L)

The Journal of Clinical Pharmacology 54(11) 1272–1279 © 2014, The American College of Clinical Pharmacology; DOI: 10.1002/jcph.333 Potential Interactions Between HIV Drugs, Ritonavir and Efavirenz and Anticancer Drug, Nilotinib—A Study in Primary Cultures of Human Hepatocytes That Is Applicable to HIV Patients With Cancer

14-Nov

David Jones, Elizabeth Sierra Potchanant, Ingrid Ferreira Metzger (L)

Clinical pharmacology & Therapeutics | VOLUME 96 NUMBER 3 | September 2014; DOI:10.1038/clpt.2014.83 Geneva Cocktail for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spots

21-Nov

Ken Levy, Noha Mourad,Tyler Shugg (L)

© 2014 by the American College of Cardiology Foundation G-Protein Beta-3 Subunit Genotype Predicts Enhanced Benefit of Fixed-Dose Isosorbide Dinitrate and Hydralazine

28-Nov

No Journal Club - Thanksgiving Holiday

   

5-Dec

Mike Ferguson, Rebecca Pierson, Anna Schwartz (L)

Early Human Development 90S1 (2014) S60–S65 Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial

12-Dec

David Haas, Jacob Zucker, Abdullah Assiri (L)

Clin Trans Sci 2014; Volume 7: 396–401 CYP2C9 Allelic Variants and Frequencies in a Pediatric Sickle Cell Disease Cohort: Implications for NSAIDs Pharmacotherapy

19-Dec

Brian Overholser, Mustafa Hyder, Kimberly Burgess (L)

PLoS ONE 9(2): e88164. doi:10.1371/journal.pone.0088164 Herg K+ Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells

26-Dec

No Journal Club - Christmas Holiday