Department of Medicine

Clinical Pharmacology

Friday Journal Club (2014)


Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.

2015 Schedule | 2014 Schedule | 2013 Schedule | 2012 Schedule | 2011 Schedule | 2010 Schedule | 2009 Schedule | 2008 Schedule | 2007 Schedule

Date Presenter Journal Title


Nieves Velez de Mendizabal, Josiane Cardoso, Tyler Shugg (L)

n engl j med 369;24
A Randomized Trial of Genotype-Guided Dosing of Warfarin


Rich Bergstrom, Costantine Albany, Tonia Gardner (L)

doi: 10.1111/bcp.12322 Influence of covariate distribution on the predictive performance of pharmacokinetic models in paediatric research


Sarah Quinney, Claire Li, Christina Chung (L) J Antimicrob Chemother 2014; 69: 180–189 doi:10.1093/jac/dkt304 Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis


Michael Eadon, Kimberly Burgess, Heqiao Dai (L)

HEPATOLOGY 2013;58:1918-1929 Once-Daily Simeprevir (TMC435) With Pegylated Interferon and Ribavirin in Treatment-Na€ıve Genotype 1 Hepatitis C: The Randomized PILLAR Study  


Beth Pflug, Anna Schwartz, Nadia Falah (L)

Sci Transl Med 6, 221ra15 (2014) Antioxidants Accelerate Lung Cancer Progression in Mice


David Thacker Bies, Nadia Falah, Noha Mourad (L)

Circ Cardiovasc Genet. 2013;6:313-316 Arrhythmia Risk in Long QT Syndrome Beyond the Disease-Causative Mutation


Supplemental material

Circ Cardiovasc Genet. 2013;6:354-361 Identification of a KCNQ1 Polymorphism Acting as a Protective Modifier Against Arrhythmic Risk in Long-QT Syndrome


Rolf Kreutz, Kruti Joshi, Heng Zhao (L)

N Engl J Med 2013;369:1206-14 Dabigatran versus Warfarin in Patients with Mechanical Heart Valves


Tom Callaghan, Deshun Lu, Mike Ferguson (L)

J Clin Oncol 31:4562-4568 Evaluating Many Treatments and Biomarkers in Oncology: A New Design


David Foster, Ayman Akil, Eric Benson (L)

Drug Metab Dispos 41:1514–1521 In Vivo Assessment of the Impact of Efflux Transporter on Oral Drug Absorption Using Portal Vein–Cannulated Rats


No Journal Club - ASCPT



No Journal Club- 4th Year Course



Lang Li, Rebecca Pierson, Jinzhong Liu (L)

Cell 149, 780–794, May 11, 2012 Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks;


Brian Decker, Elizabeth Sierra Potchanant, Costantine Albany (L)

British Journal of Cancer (2014), 1–8 | doi: 10.1038/bjc.2014.128
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives


Zeruesenay Desta, Abhishek Gulati, Josiane Cardoso (L)

doi:10.1038/clpt.2013.241 Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects


David Flockhart, Smitha Marri, Deshun Lu (L)

doi:10.1038/clpt.2013.210 Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance


Jamie Renbarger, Ingrid Ferreira Metzger, Noha Moroud (L)

Journal of the American College of Cardiology Vol. 62, No. 23, 2013 Mipomersen, an Apolipoprotein B Synthesis Inhibitor, Reduces Atherogenic Lipoproteins in Patients With Severe Hypercholesterolemia at High Cardiovascular Risk


Todd Skaar, Tyler Shugg, Kruti Joshi (L)

DOI: 10.1097/FTD.0000000000000080 CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients


David Haas, Christina Chung, Anna Schwartz (L)

Antimicrob. Agents Chemother. 2014, 58(5):2830. DOI:10.1128/AAC.01718-13. Determination of Vancomycin Pharmacokinetics in Neonates To Develop Practical Initial Dosing Recommendations


Avi Patil, Mike Ferguson, Ayman Akil (L)

PLoS ONE 8(9): e74404. doi:10.1371, September 2013 | Volume 8 | Issue 9 | e74404 Multicompartmental Pharmacokinetic Model of Tenofovir Delivery by a Vaginal Gel


No Journal Club



David Jones, Nadia Falah, Rebecca Pierson (L)

JAMA Pediatr. doi:10.1001/jamapediatrics.2013.4914 Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders


Ken Levy, Jinzhong Liu, Kimberly Burgess (L)

N Engl J Med 2013;368:1685-94 DOI: 10.1056/NEJMoa1209026 Treatment of HCV Infection by Targeting MicroRNA  


Rob Bies, Heqaio Dai, Abhishek Gulati (L)

J Thromb Haemost 2014; 12: 902–9.DOI: 10.1111/jth.12564 No effect of isolated long-term supine immobilization or profound prolonged hypoxia on blood coagulation


Brian Overholser, Tonia Gardner, Eric Benson (L)

Clinica l pharmac ology & Therapeut ics | VOLUME 95 NUMBER 4 | april 2014 doi:10.1038/clpt.2013.229 Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing


Sara Quinney, Josiane Cardoso, Smitha Marri (L)

CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 96 NUMBER 1 | JULY 2014, doi:10.1038/clpt.2014.63 Sorafenib Dose Escalation Is Not Uniformly Associated With Blood Pressure Elevations in Normotensive Patients With Advanced Malignancies


Tom Callaghan, Ayman Akil, Ingrid Ferreira Metzger (L)

NATURE COMMUNICATIONS 4 May 2013 | Accepted 27 Mar 2014 | Published 6 May 2014; DOI: 10.1038/ncomms4739 High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening


Michael Eadon, Anna Schwartz, Christina Chung (L)

Clinical pharmacology & Therapeutics: doi:10.1038/clpt.2014.131 Pulmonary Penetration of Piperacillin and Tazobactam in Critically Ill Patients


Rich Bergstrom, Noha Mourad, Heng Zhao (L)

TR-05530; doi:/10.1016/j.thromres.2014.05.019 The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study


Beth Pflug, Elizabeth Sierra Potchanant, Tyler Shugg (L)

The Journal of Clinical Pharmacology 54(8) 896–900© 2014, The American College of Clinical Pharmacology; DOI: 10.1002/jcph.332 Identification of VKORC1 Genotype Leading to Resistance to Tecarfarin


Rob Bies, Rebecca Pierson, Kimberly Burgess (L)

Blood First Edition Paper, prepublished online May 14, 2014; DOI 10.1182/blood-2014-01-552166 Adherence to oral 6-mercaptopurine in African American and Asian children with acute lymphoblastic leukemia: a Children’s Oncology Group study


David Flockhart, Jacob Zucker, Jinzhong Liu (L)

J Pharmacokinet Pharmacodyn; DOI 10.1007/s10928-012-9271-3 Modeling of Functional Assessment Questionnaire (FAQ) as continuous bounded data from the ADNI database


Costantine Albany, Abhishek Gulati, Anna Schwartz (L)

Anesthesiology, V XXX • No XXX; doi;10.1097/ALN.0000000000000391 Cyclosporine-inhibitable Cerebral Drug Transport Does Not Influence Clinical Methadone Pharmacodynamics

12- Sept

Zeruesenay Desta, Mustafa Hyder, Josiane Cardoso (L)

Clinical Pharmacology & Therapeutics; doi10.1038/clpt.2014.141 Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions


Lang Li, Ingrid Ferreira Metzger, Ayman Akil (L)

BMJ Open 2013;3:e001844. doi:10.1136/bmjopen-2012-001844 A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4inhibitors, sitagliptin and linagliptin, in treatment of type 2 diabetes mellitus


No Journal Club - CTSI Annual Meeting



David Foster, Tyler Shugg, Christina Chung (L)

Antimicrob. Agents Chemother. 2014, 58(7):3744. DOI: 10.1128/AAC.02089-13 Population Pharmacokinetic Analysis of Piperacillin in Burn Patients


Jamie Renbarger, Deshun Lu, Rebecca Pierson (L)

Pharmacogenetics and Genomics 24:348–355; DOI: 10.1097/FPC.0000000000000061 Cancer patients’ acceptance, understanding, and willingness-to-pay for pharmacogenomic testing


Todd Skaar, Noha Mourad, Jacob Zucker (L)

NATURE VOLUME 95 NUMBER 6 JUNE 2014; doi: 10.1038/clpt.2014.37 Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients


No Journal Club - Gladstein Lecture



Avi Patil, Ayman Akil, Mustafa Hyder (L)

J Clin Oncol 32:1317-1323. © 2014 by American Society of Clinical Oncology; DOI: 10.1200/JCO.2013.52.4298 Physicians’ Attitudes About Multiplex Tumor Genomic Testing


Jim Tisdale, Kimberly Burgess, Deshun Lu (L)

The Journal of Clinical Pharmacology 54(11) 1272–1279 © 2014, The American College of Clinical Pharmacology; DOI: 10.1002/jcph.333 Potential Interactions Between HIV Drugs, Ritonavir and Efavirenz and Anticancer Drug, Nilotinib—A Study in Primary Cultures of Human Hepatocytes That Is Applicable to HIV Patients With Cancer


David Jones, Elizabeth Sierra Potchanant, Ingrid Ferreira Metzger (L)

Clinical pharmacology & Therapeutics | VOLUME 96 NUMBER 3 | September 2014; DOI:10.1038/clpt.2014.83 Geneva Cocktail for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spots


Ken Levy, Noha Mourad,Tyler Shugg (L)

© 2014 by the American College of Cardiology Foundation G-Protein Beta-3 Subunit Genotype Predicts Enhanced Benefit of Fixed-Dose Isosorbide Dinitrate and Hydralazine


No Journal Club - Thanksgiving Holiday



Mike Ferguson, Rebecca Pierson, Anna Schwartz (L)

Early Human Development 90S1 (2014) S60–S65 Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial


David Haas, Jacob Zucker, Abdullah Assiri (L)

Clin Trans Sci 2014; Volume 7: 396–401 CYP2C9 Allelic Variants and Frequencies in a Pediatric Sickle Cell Disease Cohort: Implications for NSAIDs Pharmacotherapy


Brian Overholser, Mustafa Hyder, Kimberly Burgess (L)

PLoS ONE 9(2): e88164. doi:10.1371/journal.pone.0088164 Herg K+ Channel-Dependent Apoptosis and Cell Cycle Arrest in Human Glioblastoma Cells


No Journal Club - Christmas Holiday