SCHOOL OF MEDICINE

Department of Medicine

Clinical Pharmacology

Friday Journal Club (2015)

 

Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room 300B located in R3, 3rd Floor.


2015 Schedule | 2014 Schedule | 2013 Schedule | 2012 Schedule | 2011 Schedule | 2010 Schedule | 2009 Schedule | 2008 Schedule | 2007 Schedule

 
Date Presenter Journal Title

23-Jan

Rich Bergstrom, Dabei Tang, Tyler Shugg (L)

N Engl J Med 2015;372:232-40. DOI: 10.1056/NEJMoa1405760
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

30-Jan

Tom Callaghan, Thang Ho, Jason Robarge(L)

DOI: 10.1158/1078-0432.CCR-13-2233
The Impact of EGFR T790M Mutations and BIM mRNA Expression on Outcome in Patients with EGFR-Mutant NSCLC Treated with Erlotinib or Chemotherapy in the Randomized Phase III EURTAC Trial

6-Feb

Brian Decker, Chisook Moon, Ingrid Ferreira Metzger (L)

DOI: 10.1093/cid/ciu976
Cerebrospinal Fluid Exposure of Efavirenz and Its Major Metabolites When Dosed at 400 mg and 600 mg Once Daily: A Randomized Controlled Trial

13-Feb

Sara Quinney, Nimita Dave, Ayman Akil (L)

The AAPS Journal, Vol. 16, No. 4, July 2014; DOI: 10.1208/s12248-014-9614-7
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

20-Feb

Beth Pflug, Abdullah Assiri, Elizabeth Sierra Potchanant (L)

doi: 10.1111/bjh.12611
Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect

27-Feb

Rob Bies, Joseph Ipe, Noha Mourad (L)

Circ Cardiovasc Genet. 2014;7:482-490
Identification of Kv11.1 Isoform Switch as a Novel Pathogenic Mechanism of Long-QT Syndrome

6-Mar

No Journal Club - ASCPT

 
 

13-Mar

Zeruesenay Desta, Anna Schwartz, Rebecca Pierson (L)

CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 97 NUMBER 2 | FEBRUARY 2015, doi:10.1002/cpt.5
Ondansetron Pharmacokinetics in Pregnant Women and Neonates: Towards a New Treatment for Neonatal Abstinence Syndrome

20-Mar

Lang Li, Heng Zhao, Mustafa Hyder (L)

Blood. 2015;125(11):1759-1767
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

27-Mar

NO JOURNAL CLUB - 4th YEAR COURSE

 
 

3-April

Michael Eadon, Kimberly Burgess, Dabei Tang(L)

NATURE COMMUNICATIONS | 6:6601 | DOI: 10.1038/ncomms7601
Genome-wide identification of microRNA expression quantitative trait loci

10-April

David Foster, Jacob Zucker, Chisook Moon (L)

JAMA Intern Med. 2014;174(12):1938-1944. doi:10.1001/jamainternmed.2014.5266
Clinical Evidence Supporting Pharmacogenomic Biomarker Testing Provided in US Food and Drug Administration Drug Labels

17-April

Jamie Renbarger, Ayman Akil, Thank Ho (L)

Journal:  Pharm Res (2014) 31:809–818; DOI 10.1007/s11095-013-1203-4
Pharmacokinetics and Pharmacodynamics of CD4-Anchoring Bi-Functional Fusion Inhibitor in Monkeys

24-April

Todd Skaar, Jason Robarge, Nimita Dave (L)

Sci Transl Med 7, 283ra53 (2015); DOI: 10.1126/scitranslmed.aaa7161
Personalized genomic analyses for cancer mutation discovery and interpretation

1-May

Eric Benson, Tom DeLuca, Abdulla Assiri (L)

Chen et al. Journal of Translational Medicine (2015)  DOI 10.1186/s12967-015-0435-y  
miR-130a Can Predict Response to Temozolomide in Patients with Glioblastoma Multiforme, Independently of O6-Methylguanine-DNA Methyltransferase

8-May

Jim Tisdale, Rebecca Pierson, Joseph Ipe (L)

Contraception 89 (2014) 357-360

A pilot study of depot medroxyprogesterone acetate pharmacokinetics and

weight gain in adolescent females

15-May

Avi Patil, Elizabeth Sierra Potchanant, Heng Zhao (L)

DOI: 10.1158/1078-0432.CCR-12-3306

Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

22-May

David Jones, Tyler Shugg, Anna Schwartz (L)

Drug Metab Dispos 42:1292–1300, August 2014;

DOI:  10.1124/dmd.114.058339

Factors Influencing the CNS Distribution of a Novel MEK-1/2 Inhibitor: Implications for Combination Therapy for Melanoma

Brain Metastases

29-May

Ken Levy, Noha Mourad, Kimberly Burgess (L)

J Clin Invest. doi:10.1172/JCI75438.

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

5-June

Mike Ferguson, Mustafa Hyder, Jacob Zucker (L)

The Journal of Clinical Pharmacology 2015, 55(6) 661–670; DOI: 10.1002/jcph.465

Utility of Concentration-Effect Modeling and Simulation in a Thorough QT Study of Losmapimod

12-June

David Haas, Thank Ho, Ayman Akil (L)

CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 97 NUMBER 4 |doi:10.1002/cpt.63

Estimating the Contribution of Everolimus to Immunosuppressive Efficacy When Combined With Tacrolimus in Liver Transplantation: A Model-Based Approach

19-June

Brian Overholser, Nimita Dave, Jason Robarge (L)

Clin. Pharmacol. Ther. 95, 416–422(2014);  DOI:  10.1038/clpt.2013.210

Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance

26-June

David Flockhart, Abdullah Assiri, Ingrid Ferreira Metzger (L)

Drug Metab Dispos 43:433–443, April 2015;  DOI: 10.1124/dmd.114.061598

Characterization of Chrysin Glucuronidation in UGT1A1-Overexpressing HeLa Cells: Elucidating the Transporters Responsible for Efflux of Glucuronide

14-Aug

Tom Callaghan, Heng Zhao, Tom DeLuca (L)

International Journal of Oncology 46: 1181-1191, 2015;  DOI:  10.3892/ijo.2015.2833

Mathematical Analysis Predicts Imbalanced IDH1/2 Expression Associates with 2-HG-Inactivating β-Oxygenation Pathway in Colorectal Cancer”

21-Aug

Rich Bergstrom, Violeta Rodriguez Romero, Tyler Shugg (L)

Infect Dis Ther (2DOI 10.1007/s40121-015-0067-9015) 4:187–198

 

Predictive Performance of a Vancomycin Population

Pharmacokinetic Model in Neonates

28-Aug

Brian Decker, Kimberly Burgess, Mustafa Hyder (L)

JAMA Oncol. 2015;1(3):350-358. doi:10.1001/jamaoncol.2015.0388

Increased Plasma Levels of Chemoresistance-Inducing Fatty

Acid 16:4(n-3) After Consumption of Fish and Fish Oil

4-Sept

Sara Quinney, Auman Akil, Nimita Dave (L)

CLINICAL PHARMACOLOGY & THERAPEUTICS:  doi:10.1002/cpt.155

Physiologically Based and Population PK

Modeling in Optimizing Drug Development:

A Predict–Learn–Confirm Analysis

11-Sept

Zereusenay Desta, Ingrid Ferreira Metzger, Abdullah Assiri (L)

N Engl J Med 2015;373:795-807.

DOI: 10.1056/NEJMoa1506816

Initiation of Antiretroviral Therapy in Early Asymptomatic

HIV Infection

18-Sept

Michael Eadon, Brandon Gufford, Jason Robarge (L)

PLoS ONE 10(6): e0127791. doi:10.1371/

journal.pone.0127791

Genome-Wide Association Study of Serum

Creatinine Levels during Vancomycin

Therapy

25-Sept

Erin Benson, Oliver Schantz, Violeta Rodriguez Romero (L)

Journal of Pharmaceutical and Biomedical Analysis 107 (2015) 196-203; DOI:10.1016/j.jpba.2014.12.009

A novel, simple and inexpensive procedure for the simultaneousdetermination of iopamidol and p-aminohippuric acid for renalfunction assessment from plasma samples in awake rats

2-Oct

Avi Patil, Ellen Go, Rebecca Pierson (L)

The Pharmacogenomics Journal (2013) 13, 362 -- 368; DOI:10.1038/tpj.2012.21

Transgenic mouse model reveals an unsuspected role of the

acetylcholine receptor in statin-induced neuromuscular adverse

drug reactions

9-Oct

Todd Skaar, Fernanda de Lima Moreira, Heng Zhao (L)

Drug Metab Dispos 43:208–216, February 2015. DOI: 10.1124/dmd.114.061812

Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model:  Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo s

16-Oct

David Haas, Joseph Ipe, Ayman Akil (L)

Am J Obstet Gynecol. 2010 April ; 202(4): 383.e1–383.e7. doi:10.1016/j.ajog.2010.01.035

Role of human placental apical membrane transporters in the

efflux of glyburide, rosiglitazone, and metformin

23-Oct

David Jones, Jacki Carter, Kimberly Burgess (L)

Thrombosis Research 136 (2015) 367-370; doi: 10.1016/j.thromres.2015.06.026

Could MicroRNA polymorphisms influence warfarin dosing? A

pharmacogenetics study on mir133 genes

30-Oct

Ken Levy, Tom DeLuca, Brandon Gufford (L) Lancet 2015: 385: 2080-87; doi: 10.1016/

S0140-6736(14)61994-2

Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind

ENGAGE AF-TIMI 48 trial

6-Nov

Jim Tisdale, Tyler Shugg, Oliver Schantz (L)

N Engl J Med 2015;373:895-907.

DOI: 10.1056/NEJMoa1502214

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

13-Nov

Brian Overholser, Mustafa Hyder, Ingrid Ferriera Metzger (L)

Clinical Trial; doi:10.1002/cpt.60

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

20-Nov

Lang Li, Abdullah Assiri, Joseph Ipe (L) Pharmacogenomics (2015) 16(12), 1379–1386; DOI:10.2217/PGS.15.82

Hsa-miR-27 is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population

27-Nov

  No Journal Club - Thanksgiving Holiday  

4-Dec

Elena Tomaselli, Jason Robarge, Fernanda de Lima Moreira (L) Br J Clin Pharmacol. 2015 Sep; 80(3): 548-59, doi: 10.1111/bcp.12703 Progressive decline in tacrolimus clearance after rental transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit

11-Dec

Nimita Dave, Rebecca Pierson (L) Am J Obstet Gynecol. 2015 Oct; 213(4): 543.e.1-7. doi: 10.1016/j.ajob.2015.06.034 Pharmaccokinetics of cefazolin prophylaxis in obese gravidae at time of cesarean delivery

18-Dec

Heng Zhao, Jacob Zucker (L) Cancer Gene Ther. 2007 Dec; 14(12); 935-44; doi: 10.1038/sj.cgt.7701092 Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model

25-Dec

  No Journal Club - Christmas Holiday