| Date |
Presenter |
Journal |
Title |
|
23-Jan
|
Rich Bergstrom, Dabei Tang, Tyler Shugg (L)
|
N Engl J Med 2015;372:232-40. DOI: 10.1056/NEJMoa1405760 |
Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
|
|
30-Jan
|
Tom Callaghan, Thang Ho, Jason Robarge(L)
|
DOI: 10.1158/1078-0432.CCR-13-2233 |
The Impact of EGFR T790M Mutations and BIM mRNA Expression on Outcome in Patients with EGFR-Mutant NSCLC Treated with Erlotinib or Chemotherapy in the Randomized Phase III EURTAC Trial
|
|
6-Feb
|
Brian Decker, Chisook Moon, Ingrid Ferreira Metzger (L)
|
DOI: 10.1093/cid/ciu976 |
Cerebrospinal Fluid Exposure of Efavirenz and Its Major Metabolites When Dosed at 400 mg and 600 mg Once Daily: A Randomized Controlled Trial
|
|
13-Feb
|
Sara Quinney, Nimita Dave, Ayman Akil (L)
|
The AAPS Journal, Vol. 16, No. 4, July 2014; DOI: 10.1208/s12248-014-9614-7 |
Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide
|
|
20-Feb
|
Beth Pflug, Abdullah Assiri, Elizabeth Sierra Potchanant (L)
|
doi: 10.1111/bjh.12611 |
Antileukaemic effect of PI3K-mTOR inhibitors in acute myeloid leukaemia-gene expression profiles reveal CDC25B expression as determinate of pharmacological effect
|
|
27-Feb
|
Rob Bies, Joseph Ipe, Noha Mourad (L)
|
Circ Cardiovasc Genet. 2014;7:482-490 |
Identification of Kv11.1 Isoform Switch as a Novel Pathogenic Mechanism of Long-QT Syndrome
|
|
6-Mar
|
No Journal Club - ASCPT
|
|
|
|
13-Mar
|
Zeruesenay Desta, Anna Schwartz, Rebecca Pierson (L)
|
CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 97 NUMBER 2 | FEBRUARY 2015, doi:10.1002/cpt.5 |
Ondansetron Pharmacokinetics in Pregnant Women and Neonates: Towards a New Treatment for Neonatal Abstinence Syndrome
|
|
20-Mar
|
Lang Li, Heng Zhao, Mustafa Hyder (L)
|
Blood. 2015;125(11):1759-1767 |
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
|
|
27-Mar
|
NO JOURNAL CLUB - 4th YEAR COURSE
|
|
|
|
3-April
|
Michael Eadon, Kimberly Burgess, Dabei Tang(L)
|
NATURE COMMUNICATIONS | 6:6601 | DOI: 10.1038/ncomms7601 |
Genome-wide identification of microRNA expression quantitative trait loci
|
|
10-April
|
David Foster, Jacob Zucker, Chisook Moon (L)
|
JAMA Intern Med. 2014;174(12):1938-1944. doi:10.1001/jamainternmed.2014.5266 |
Clinical Evidence Supporting Pharmacogenomic Biomarker Testing Provided in US Food and Drug Administration Drug Labels
|
|
17-April
|
Jamie Renbarger, Ayman Akil, Thank Ho (L)
|
Journal: Pharm Res (2014) 31:809–818; DOI 10.1007/s11095-013-1203-4 |
Pharmacokinetics and Pharmacodynamics of CD4-Anchoring Bi-Functional Fusion Inhibitor in Monkeys
|
|
24-April
|
Todd Skaar, Jason Robarge, Nimita Dave (L)
|
Sci Transl Med 7, 283ra53 (2015); DOI: 10.1126/scitranslmed.aaa7161 |
Personalized genomic analyses for cancer mutation discovery and interpretation
|
|
1-May
|
Eric Benson, Tom DeLuca, Abdulla Assiri (L)
|
Chen et al. Journal of Translational Medicine (2015) DOI 10.1186/s12967-015-0435-y |
miR-130a Can Predict Response to Temozolomide in Patients with Glioblastoma Multiforme, Independently of O6-Methylguanine-DNA Methyltransferase
|
|
8-May
|
Jim Tisdale, Rebecca Pierson, Joseph Ipe (L)
|
Contraception 89 (2014) 357-360 |
A pilot study of depot medroxyprogesterone acetate pharmacokinetics and
weight gain in adolescent females
|
|
15-May
|
Avi Patil, Elizabeth Sierra Potchanant, Heng Zhao (L)
|
DOI: 10.1158/1078-0432.CCR-12-3306
|
Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
|
|
22-May
|
David Jones, Tyler Shugg, Anna Schwartz (L)
|
Drug Metab Dispos 42:1292–1300, August 2014;
DOI: 10.1124/dmd.114.058339
|
Factors Influencing the CNS Distribution of a Novel MEK-1/2 Inhibitor: Implications for Combination Therapy for Melanoma
Brain Metastases
|
|
29-May
|
Ken Levy, Noha Mourad, Kimberly Burgess (L)
|
J Clin Invest. doi:10.1172/JCI75438.
|
MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids
|
|
5-June
|
Mike Ferguson, Mustafa Hyder, Jacob Zucker (L)
|
The Journal of Clinical Pharmacology 2015, 55(6) 661–670; DOI: 10.1002/jcph.465
|
Utility of Concentration-Effect Modeling and Simulation in a Thorough QT Study of Losmapimod
|
|
12-June
|
David Haas, Thank Ho, Ayman Akil (L)
|
CLINICAL PHARMACOLOGY & THERAPEUTICS | VOLUME 97 NUMBER 4 |doi:10.1002/cpt.63
|
Estimating the Contribution of Everolimus to Immunosuppressive Efficacy When Combined With Tacrolimus in Liver Transplantation: A Model-Based Approach
|
|
19-June
|
Brian Overholser, Nimita Dave, Jason Robarge (L)
|
Clin. Pharmacol. Ther. 95, 416–422(2014); DOI: 10.1038/clpt.2013.210
|
Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance
|
|
26-June
|
David Flockhart, Abdullah Assiri, Ingrid Ferreira Metzger (L)
|
Drug Metab Dispos 43:433–443, April 2015; DOI: 10.1124/dmd.114.061598
|
Characterization of Chrysin Glucuronidation in UGT1A1-Overexpressing HeLa Cells: Elucidating the Transporters Responsible for Efflux of Glucuronide
|
|
14-Aug
|
Tom Callaghan, Heng Zhao, Tom DeLuca (L) |
International Journal of Oncology 46: 1181-1191, 2015; DOI: 10.3892/ijo.2015.2833
|
“Mathematical Analysis Predicts Imbalanced IDH1/2 Expression Associates with 2-HG-Inactivating β-Oxygenation Pathway in Colorectal Cancer” |
|
21-Aug
|
Rich Bergstrom, Violeta Rodriguez Romero, Tyler Shugg (L) |
Infect Dis Ther (2DOI 10.1007/s40121-015-0067-9015) 4:187–198
|
Predictive Performance of a Vancomycin Population
Pharmacokinetic Model in Neonates
|
|
28-Aug
|
Brian Decker, Kimberly Burgess, Mustafa Hyder (L) |
JAMA Oncol. 2015;1(3):350-358. doi:10.1001/jamaoncol.2015.0388
|
Increased Plasma Levels of Chemoresistance-Inducing Fatty
Acid 16:4(n-3) After Consumption of Fish and Fish Oil
|
|
4-Sept
|
Sara Quinney, Auman Akil, Nimita Dave (L) |
CLINICAL PHARMACOLOGY & THERAPEUTICS: doi:10.1002/cpt.155
|
Physiologically Based and Population PK
Modeling in Optimizing Drug Development:
A Predict–Learn–Confirm Analysis
|
|
11-Sept
|
Zereusenay Desta, Ingrid Ferreira Metzger, Abdullah Assiri (L) |
N Engl J Med 2015;373:795-807.
DOI: 10.1056/NEJMoa1506816
|
Initiation of Antiretroviral Therapy in Early Asymptomatic
HIV Infection
|
|
18-Sept
|
Michael Eadon, Brandon Gufford, Jason Robarge (L) |
PLoS ONE 10(6): e0127791. doi:10.1371/
journal.pone.0127791
|
Genome-Wide Association Study of Serum
Creatinine Levels during Vancomycin
Therapy
|
|
25-Sept
|
Erin Benson, Oliver Schantz, Violeta Rodriguez Romero (L) |
Journal of Pharmaceutical and Biomedical Analysis 107 (2015) 196-203; DOI:10.1016/j.jpba.2014.12.009
|
A novel, simple and inexpensive procedure for the simultaneousdetermination of iopamidol and p-aminohippuric acid for renalfunction assessment from plasma samples in awake rats
|
|
2-Oct
|
Avi Patil, Ellen Go, Rebecca Pierson (L) |
The Pharmacogenomics Journal (2013) 13, 362 -- 368; DOI:10.1038/tpj.2012.21
|
Transgenic mouse model reveals an unsuspected role of the
acetylcholine receptor in statin-induced neuromuscular adverse
drug reactions
|
|
9-Oct
|
Todd Skaar, Fernanda de Lima Moreira, Heng Zhao (L) |
Drug Metab Dispos 43:208–216, February 2015. DOI: 10.1124/dmd.114.061812
|
Characterization of CYP2B6 in a CYP2B6-Humanized Mouse Model: Inducibility in the Liver by Phenobarbital and Dexamethasone and Role in Nicotine Metabolism In Vivo s
|
|
16-Oct
|
David Haas, Joseph Ipe, Ayman Akil (L) |
Am J Obstet Gynecol. 2010 April ; 202(4): 383.e1–383.e7. doi:10.1016/j.ajog.2010.01.035
|
Role of human placental apical membrane transporters in the
efflux of glyburide, rosiglitazone, and metformin
|
|
23-Oct
|
David Jones, Jacki Carter, Kimberly Burgess (L) |
Thrombosis Research 136 (2015) 367-370; doi: 10.1016/j.thromres.2015.06.026
|
Could MicroRNA polymorphisms influence warfarin dosing? A
pharmacogenetics study on mir133 genes
|
|
30-Oct
|
Ken Levy, Tom DeLuca, Brandon Gufford (L) |
Lancet 2015: 385: 2080-87; doi: 10.1016/
S0140-6736(14)61994-2
|
Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind
ENGAGE AF-TIMI 48 trial
|
|
6-Nov
|
Jim Tisdale, Tyler Shugg, Oliver Schantz (L) |
N Engl J Med 2015;373:895-907.
DOI: 10.1056/NEJMoa1502214
|
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans |
|
13-Nov
|
Brian Overholser, Mustafa Hyder, Ingrid Ferriera Metzger (L) |
Clinical Trial; doi:10.1002/cpt.60
|
Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase
|
|
20-Nov
|
Lang Li, Abdullah Assiri, Joseph Ipe (L) |
Pharmacogenomics (2015) 16(12), 1379–1386; DOI:10.2217/PGS.15.82 |
Hsa-miR-27 is involved in the regulation of CYP3A4 expression in human livers from Chinese Han population
|
|
27-Nov
|
|
No Journal Club - Thanksgiving Holiday |
|
|
4-Dec
|
Elena Tomaselli, Jason Robarge, Fernanda de Lima Moreira (L) |
Br J Clin Pharmacol. 2015 Sep; 80(3): 548-59, doi: 10.1111/bcp.12703 |
Progressive decline in tacrolimus clearance after rental transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit |
|
11-Dec
|
Nimita Dave, Rebecca Pierson (L) |
Am J Obstet Gynecol. 2015 Oct; 213(4): 543.e.1-7. doi: 10.1016/j.ajob.2015.06.034 |
Pharmaccokinetics of cefazolin prophylaxis in obese gravidae at time of cesarean delivery |
|
18-Dec
|
Heng Zhao, Jacob Zucker (L) |
Cancer Gene Ther. 2007 Dec; 14(12); 935-44; doi: 10.1038/sj.cgt.7701092 |
Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model |
|
25-Dec
|
|
No Journal Club - Christmas Holiday |
|