Department of Medicine

Clinical Pharmacology

Friday Journal Club (2008)


Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.

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Date Presenter Journal Title
JAN 4 No Journal Club    
JAN 11 No Journal Club    
JAN 18 No Journal Club    
JAN 25 No Journal Club    
FEB 1 Todd Skaar Nat Methods. 2007 Nov;4(11):903-5. Direct selection of human genomic loci by microarray hybridization
FEB 8 Noam Epstein J Pharmacol Exp Ther. 2004 Jul;310(1):376-85. Disposition Mechanisms of Raloxifene in the Human Intestinal Caco-2 Model
FEB 15 Kevin Sowinski Br J Clin Pharmacol. 2006 August; 62(2): 165–176. Development of a dosage strategy in patients receiving enoxaparin by continuous intravenous infusion using modelling and simulation
FEB 22 Jia Miao Circulation. 2007 Dec 18;116(25):2923-32. Prasugrel Compared With High Loading- and Maintenance-Dose Clopidogrel in Patients With Planned Percutaneous Coronary Intervention
FEB 29 David Flockhart    
MAR 7 Matt Strother Eur J Cancer. 2008 Jan;44(1):142-50. Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-b kinase antagonist, in mice
MAR 14 Million (Six) Arefayene J Immunol. 2001 May 15;166(10):6332-40. Antioxidants Inhibit Indoleamine 2,3-Dioxygenase in IFN-g-Activated Human Macrophages: Posttranslational Regulation by Pyrrolidine Dithiocarbamate1
MAR 21     No Journal Club - Holiday
MAR 28     No Journal Club - PREGMED Conference
APR 4     No Journal Club - ASCPT Conference
APR 11     No Journal Club
APR 18     No Journal Club
APR 25 Raymond Galinsky Mol Pharmacol. 2007 Oct;72(4):826-37. Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-Responsive Enhancer Binding Protein (Nuclear Factor of Activated T Cells 5)
MAY 2     No Journal Club - Great Lakes Drug Metabolism Discussion Group
MAY 9     No Journal Club
MAY 23 Srikar Malireddy Clin Cancer Res. 2008 May 1;14(9):2601-8. A Five-GeneMolecular Grade Index and HOXB13:IL17BR Are Complementary Prognostic Factors in Early Stage Breast Cancer
MAY 30     No Journal Club
JUN 6     No Journal Club
JUN 13 Noam Epstein Drug Metab Dispos. 2007 Aug;35(8):1254-61. UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms and Total Bilirubin Levels in an Ethnically Diverse Cohort of Women
JUN 20 Anuradha Ramamoorthy J Biol Chem. 2008 Apr 11;283(15):9674-80. Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4
JUN 27 Todd Skaar Drug Metab Dispos. 2008 May 12. Developmental Changes in Human Liver CYP2D6 Expression
JUL 4     No Journal Club
JUL 11 David Haas Obstet Gynecol. 2008 Jul;112(1):109-15. Effects of L-Isoleucine and L-Valine on Hot Flushes and Serum Homocysteine
JUL 18     No Journal Club
JUL 25 Todd Skaar Pharmacogenet Genomics. 2008 Aug;18(8):683-97. Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene
AUG 1     No Journal Club
AUG 8     No Journal Club
AUG 15     No Journal Club
AUG 22 Kevin Sowinski
Brian Overholser ADAPT Tutorial: ADAPT is a set of high-level programs for simulation, data analysis and design of experiments, designed primarily for basic and clinical research modeling and data analysis applications involving pharmacokinetic and pharmacodynamic systems.
AUG 29 Lang Li Br J Clin Pharmacol. 2007 Jul;64(1):14-26. The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies – CYP2C9 and warfarin as an example
SEP 5 James Tisdale Circulation. 2008 Mar 25;117(12):1518-25. Vernakalant Hydrochloride for Rapid Conversion of Atrial Fibrillation: A Phase 3, Randomized, Placebo-Controlled Trial
SEP 12 Tom Callaghan J Clin Oncol. 2008 Apr 1;26(10):1596-602. Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data
SEP 19 Ray Galinsky Mol Pharmacol. 2008 Sep;74(3):714-23. Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course
SEP 26 Lauren (Nicki) Bell Clin Pharmacol Ther. 2005 Aug;78(2):202-8. Effects of Pro12Ala polymorphism of peroxisome proliferator–activated receptor γ2 gene on rosiglitazone response in type 2 diabetes
OCT 3 Jason Robarge Eur J Neurosci. 2001 Jun;13(12):2227-33. Sex hormones regulate the contribution of PKCε and PKA signaling in inflammatory pain in the rat
OCT 10 Sherry Pittman J Neurosci. 2004 Aug 11;24(32):7159-66. Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1A Receptor
OCT 17     No Journal Club
OCT 24 Zeruesenay Desta Clin Pharmacol Ther. 2008 Nov;84(5):589-94. Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4ß-Hydroxycholesterol
OCT 31 Anuradha Ramamoorthy Drug Metab Pharmacokinet. 2007 Aug;22(4):287-98. Role of Human Hepatocyte Nuclear Factor 4a in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA
NOV 7 David Haas Am J Obstet Gynecol. 2008 Sep;199(3):276.e1-8. One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency
NOV 14     No Journal Club - COBRA Meeting
NOV 21 Landry Kamdem Kamdem Breast Cancer Res Treat. 2008 Apr;108(3):421-6. Tamoxifen, hot flashes and recurrence in breast cancer
NOV 28 Holiday    
DEC 5 Noam Epstein J Neurosci. 2005 Dec 14;25(50):11495-503. IgG-Assisted Age-Dependent Clearance of Alzheimer's Amyloid Beta Peptide by the Blood–Brain Barrier Neonatal Fc Receptor
DEC 12 David Flockhart Molecular Psychiatry (2008) Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia
DEC 19 Jessie Lu Anesthesiology. 2008 Mar;108(3):363-74. Role of CYP2B6 in Stereoselective Human Methadone Metabolism
DEC 26 Holiday