| Date |
Presenter |
Journal |
Title |
| JAN 4 |
No Journal Club |
|
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| JAN 11 |
No Journal Club |
|
|
| JAN 18 |
No Journal Club |
|
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| JAN 25 |
No Journal Club |
|
|
| FEB 1 |
Todd Skaar |
Nat Methods. 2007 Nov;4(11):903-5. |
Direct selection of human genomic loci by microarray hybridization |
| FEB 8 |
Noam Epstein |
J Pharmacol Exp Ther. 2004 Jul;310(1):376-85. |
Disposition Mechanisms of Raloxifene in the Human Intestinal Caco-2 Model |
| FEB 15 |
Kevin Sowinski |
Br J Clin Pharmacol. 2006 August; 62(2): 165–176. |
Development of a dosage strategy in patients receiving enoxaparin by continuous intravenous infusion using modelling and simulation |
| FEB 22 |
Jia Miao |
Circulation. 2007 Dec 18;116(25):2923-32. |
Prasugrel Compared With High Loading- and Maintenance-Dose Clopidogrel in Patients With Planned Percutaneous Coronary Intervention |
| FEB 29 |
David Flockhart |
|
|
| MAR 7 |
Matt Strother |
Eur J Cancer. 2008 Jan;44(1):142-50. |
Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-b kinase antagonist, in mice |
| MAR 14 |
Million (Six) Arefayene |
J Immunol. 2001 May 15;166(10):6332-40. |
Antioxidants Inhibit Indoleamine 2,3-Dioxygenase in IFN-g-Activated Human Macrophages: Posttranslational Regulation by Pyrrolidine Dithiocarbamate1 |
| MAR 21 |
|
|
No Journal Club - Holiday |
| MAR 28 |
|
|
No Journal Club - PREGMED Conference |
| APR 4 |
|
|
No Journal Club - ASCPT Conference |
| APR 11 |
|
|
No Journal Club |
| APR 18 |
|
|
No Journal Club |
| APR 25 |
Raymond Galinsky |
Mol Pharmacol. 2007 Oct;72(4):826-37. |
Discovery of Osmosensitive Transcriptional Regulation of Human Cytochrome P450 3As by the Tonicity-Responsive Enhancer Binding Protein (Nuclear Factor of Activated T Cells 5) |
| MAY 2 |
|
|
No Journal Club - Great Lakes Drug Metabolism Discussion Group |
| MAY 9 |
|
|
No Journal Club |
| MAY 23 |
Srikar Malireddy |
Clin Cancer Res. 2008 May 1;14(9):2601-8. |
A Five-GeneMolecular Grade Index and HOXB13:IL17BR Are Complementary Prognostic Factors in Early Stage Breast Cancer |
| MAY 30 |
|
|
No Journal Club |
| JUN 6 |
|
|
No Journal Club |
| JUN 13 |
Noam Epstein |
Drug Metab Dispos. 2007 Aug;35(8):1254-61. |
UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms and Total Bilirubin Levels in an Ethnically Diverse Cohort of Women |
| JUN 20 |
Anuradha Ramamoorthy |
J Biol Chem. 2008 Apr 11;283(15):9674-80. |
Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4 |
| JUN 27 |
Todd Skaar |
Drug Metab Dispos. 2008 May 12. |
Developmental Changes in Human Liver CYP2D6 Expression |
| JUL 4 |
|
|
No Journal Club |
| JUL 11 |
David Haas |
Obstet Gynecol. 2008 Jul;112(1):109-15. |
Effects of L-Isoleucine and L-Valine on Hot Flushes and Serum Homocysteine |
| JUL 18 |
|
|
No Journal Club |
| JUL 25 |
Todd Skaar |
Pharmacogenet Genomics. 2008 Aug;18(8):683-97. |
Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene |
| AUG 1 |
|
|
No Journal Club |
| AUG 8 |
|
|
No Journal Club |
| AUG 15 |
|
|
No Journal Club |
| AUG 22 |
Kevin Sowinski
Brian Overholser |
bmsr.usc.edu |
ADAPT Tutorial: ADAPT is a set of high-level programs for simulation, data analysis and design of experiments, designed primarily for basic and clinical research modeling and data analysis applications involving pharmacokinetic and pharmacodynamic systems. |
| AUG 29 |
Lang Li |
Br J Clin Pharmacol. 2007 Jul;64(1):14-26. |
The use of mechanistic DM-PK-PD modelling to assess the power of pharmacogenetic studies – CYP2C9 and warfarin as an example |
| SEP 5 |
James Tisdale |
Circulation. 2008 Mar 25;117(12):1518-25. |
Vernakalant Hydrochloride for Rapid Conversion of Atrial Fibrillation: A Phase 3, Randomized, Placebo-Controlled Trial |
| SEP 12 |
Tom Callaghan |
J Clin Oncol. 2008 Apr 1;26(10):1596-602. |
Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data |
| SEP 19 |
Ray Galinsky |
Mol Pharmacol. 2008 Sep;74(3):714-23. |
Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course |
| SEP 26 |
Lauren (Nicki) Bell |
Clin Pharmacol Ther. 2005 Aug;78(2):202-8. |
Effects of Pro12Ala polymorphism of peroxisome proliferator–activated receptor γ2 gene on rosiglitazone response in type 2 diabetes |
| OCT 3 |
Jason Robarge |
Eur J Neurosci. 2001 Jun;13(12):2227-33. |
Sex hormones regulate the contribution of PKCε and PKA signaling in inflammatory pain in the rat |
| OCT 10 |
Sherry Pittman |
J Neurosci. 2004 Aug 11;24(32):7159-66. |
Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1A Receptor |
| OCT 17 |
|
|
No Journal Club |
| OCT 24 |
Zeruesenay Desta |
Clin Pharmacol Ther. 2008 Nov;84(5):589-94. |
Cytochrome P450 Induction by Rifampicin in Healthy Subjects: Determination Using the Karolinska Cocktail and the Endogenous CYP3A4 Marker 4ß-Hydroxycholesterol |
| OCT 31 |
Anuradha Ramamoorthy |
Drug Metab Pharmacokinet. 2007 Aug;22(4):287-98. |
Role of Human Hepatocyte Nuclear Factor 4a in the Expression of Drug-Metabolizing Enzymes and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA |
| NOV 7 |
David Haas |
Am J Obstet Gynecol. 2008 Sep;199(3):276.e1-8. |
One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency |
| NOV 14 |
|
|
No Journal Club - COBRA Meeting |
| NOV 21 |
Landry Kamdem Kamdem |
Breast Cancer Res Treat. 2008 Apr;108(3):421-6. |
Tamoxifen, hot flashes and recurrence in breast cancer |
| NOV 28 |
Holiday |
|
|
| DEC 5 |
Noam Epstein |
J Neurosci. 2005 Dec 14;25(50):11495-503. |
IgG-Assisted Age-Dependent Clearance of Alzheimer's Amyloid Beta Peptide by the Blood–Brain Barrier Neonatal Fc Receptor |
| DEC 12 |
David Flockhart |
Molecular Psychiatry (2008) |
Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia |
| DEC 19 |
Jessie Lu |
Anesthesiology. 2008 Mar;108(3):363-74. |
Role of CYP2B6 in Stereoselective Human Methadone Metabolism |
| DEC 26 |
Holiday |
|
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