Department of Medicine

Clinical Pharmacology

Friday Journal Club (2009)


Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.

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Date Presenter Journal Title
JAN 2     No Journal Club
JAN 9 Todd Skaar, PhD N Engl J Med. 2008 Dec 22. Cytochrome P-450 Polymorphisms and Response to Clopidogrel
JAN 16     No Journal Club
JAN 23 Kelley Krizek, Clin Pharm Grad Student Br J Pharmacol. 2007 Jun;151(3):384-95. Differential effects of selective oestrogen receptor modulators (SERMs) tamoxifen, ospemifene and raloxifene on human osteoclasts in vitro
JAN 30 Tom Callaghan, MD, PhD Blood. 2008 Apr 15;111(8):4106-12. CYP4F2 genetic variant alters required warfarin dose
FEB 6 Alette Wessels Diabetes. 2008 Feb;57(2):325-31. Glucagon-Like Peptide-1 Inhibits Blood-Brain Glucose Transfer in Humans
FEB 13 Brain Overholser Circulation. 2009 Jan 20;119(2):215-21. High Efficacy of 2-Blockers in Long-QT Syndrome Type 1: Contribution of Noncompliance and QT-Prolonging Drugs to the Occurrence of 2-Blocker Treatment "Failures"
FEB 20 Anne Nguyen J Clin Oncol. 2008 Feb 1;26(4):556-62. Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer
FEB 27     No Journal Club
MAR 6 James Tisdale Arch Intern Med. 2008 Apr 28;168(8):826-31. Use of Alendronate and Risk of Incident Atrial Fibrillation in Women
MAR 13      
MAR 20      
MAR 27      
APR 3      
APR 10      
APR 17 YangWeon Kim Clin Pharmacol Ther. 2008 Jan;83(1):52-60. Cyclooxygenase Polymorphisms and Risk of Cardiovascular Events: The Atherosclerosis Risk in Communities (ARIC) Study
APR 24 Sherry Phillips Brain Res. 2008 Oct 9;1234:66-77. Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat
MAY 1 Jason Robarge Nat Med. 2006 Nov;12(11):1269-77. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
MAY 8 David Thacker Clin Pharmacol Ther. 2008 Sep;84(3):347-61. Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations
MAY 15 Anuradha Ramamoorthy J Biol Chem. 2008 Nov 7;283(45):31079-86. MicroRNA-221/222 negatively regulates ERα and associates with tamoxifen resistance in breast cancer
MAY 22 Landry Kamdem Pharmacogenomics. 2008 Nov;9(11):1617-22. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.
MAY 29 Jessie Lu Br J Clin Pharmacol. 2009 Apr;67(4):386-93. Morphine is an arteriolar vasodilator in man
JUN 5 Noam Epstein N Engl J Med. 2006 Oct 12;355(15):1525-38. Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease
JUN 12 David Haas N Engl J Med. 2009 Apr 16;360(16):1597-605.

N Engl J Med. 2009 Apr 16;360(16):1667-9.
Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs.

Which Drug for the Pregnant Woman with Epilepsy?
JUN 19 Todd Skaar Clin Chem. 2009 55:8. CYP2D6 Genotyping for Functional-Gene Dosage Analysis by Allele Copy Number Detection
JUN 26 David Flockhart J Natl Cancer Inst. 1999 Dec 1;91(23):2001-8. Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus
JUL 3     No Journal Club
JUL 10 Kelley Krizek Nat Med. 2009 Apr;15(4):417-24. Estrogen-dependent and C-C chemokine receptor-2–dependent pathways determine osteoclast behavior in osteoporosis
JUL 17     No Journal Club
JUL 24 John Callaghan Biochem Biophys Res Commun. 2008 Sep 19;374(2):341-4. Inflammation stimulates the expression of PCSK9
JUL 31 Alette Wessels Diabetologia. 2009 Jun 30. Risk of malignancies in patients with diabetes treated with human insulin or insulin analogues: a cohort study
AUG 7 Brain Overholser Nat Med. 2009 Apr;15(4):380-3.
+ Supplemental Material
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
AUG 14 Kelley Krizek Discuss experimental design for written proposal for qualifying exam.
AUG 21   No Journal Club
AUG 28 Ray Galinsky Hepatology. 2009 Aug;50(2):622-9. Constitutive Androstane Receptor Mediates the Induction of Drug Metabolism in Mouse Models of Type 1 Diabetes
SEP 4 Nikki Bell Hepatology. 2008 Aug;48(2):588-96. Glutathione S-Transferase M1 and T1 Null Genotypes Increase Susceptibility to Idiosyncratic Drug-Induced Liver Injury
SEP 11 Jason Robarge Mechanisms and genetic mediators of aromatase inhibitor-induced hypernociception
SEP 18 Beth Pflug



ETS Family Transcription Factors Collaborate with Alternative Signaling Pathways to Induce Carcinoma from Adult Murine Prostate Cells
SEP 25 Doo-Yeoun Cho CPT. 2009 Aug 19. Association of Cyp2B6, Cyp3A5 and Cyp2C19 Genetic Polymorphisms with Sibtramine PK in Healthy Koreans.
OCT 2 Zeruesenay Desta

Efavirenz vs Raltegravir (Editorial)

Efavirenz vs Raltegravir

Efavirenz vs Raltegravir
OCT 9   No Journal Club
OCT 16 David Flockhart Clin Pharmacol Ther. 2009 Oct;86(4):396-402. Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
OCT 23 Troy Quigg Pediatr Transplant. 2009 Jun;13(4):444-50. Pharmacokinetic monitoring of intravenous cyclosporine A in pediatric stem-cell transplant recipients. The trough level is not enough
OCT 30 David Haas Clin Pharmacokinet. 2009;48(10):677-83. Effect of Cytochrome P450 2D6 Genotype on Maternal Paroxetine Plasma Concentrations during Pregnancy
NOV 6   No Journal Club
NOV 13 Todd Skaar Nat Genet. 2009 Nov 8.
+ Supplemental Figures
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
NOV 20   No Journal Club
NOV 27 Holiday No Journal Club
DEC 4 Tom Callaghan N Engl J Med. 2009 Sep 17;361(12):1139-51. Dabigatran versus Warfarin in Patients with Atrial Fibrillation
DEC 11 YangWeon Kim Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4402-7. Circulating microRNAs, potential biomarkers for drug-induced liver injury
DEC 18   No Journal Club
DEC 25 Happy Holidays No Journal Club