SCHOOL OF MEDICINE

Department of Medicine

Clinical Pharmacology

Friday Journal Club (2010)

 

Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.


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Date Presenter Journal Title
JAN 1     No Journal Club
JAN 8 Anuradha Ramamoorthy Drug Metab Dispos. 2009 Oct;37(10):2112-7. MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targetingâ–ˇ
JAN 15 David Flockhart J Pharmacol Exp Ther. 2009 Oct 23. CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin auto-induction of clearance and maintenance dose
JAN 22 Jason Robarge Exp Gerontol. 2009 Jun-Jul;44(6-7):398-405. Immoderate inhibition of estrogen by anastrozole enhances the severity of experimental polyarthritis
JAN 29 Landry Kamdem Kamdem Cancer Res. 2010 Jan 1;70(1):319-28. Functional Genetic Polymorphisms in the Aromatase Gene CYP19 Vary the Response of Breast Cancer Patients to Neoadjuvant Therapy with Aromatase Inhibitors
FEB 5 Xu Han Drug Metab Dispos. 2010 Mar;38(3):376-85. Identification of Cytochrome P450 Isoforms Involved in the Metabolism of Paroxetine and Estimation of Their Importance for Human Paroxetine Metabolism using a Population-Based Simulator
FEB 12 Todd Skaar BMJ. 2010 Feb 8;340:c693. Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study
FEB 19 James Tisdale JAMA. 2008 Oct 15;300(15):1784-92. Continuous vs Episodic Prophylactic Treatment With Amiodarone for the Prevention of Atrial Fibrillation: A Randomized Trial
FEB 26 Robert Bies Clin Pharmacol Ther. 2009 Aug;86(2):167-74. Elucidation of Relationship Between Tumor Size and Survival in Non-Small-Cell Lung Cancer Patients Can Aid Early Decision Making in Clinical Drug Development
MAR 5 Lauren Bell Clin Pharmacol Ther. 2009 Dec;86(6):644-50. Orally Administered Glucagon-Like Peptide-1 Affects Glucose Homeostasis Following an Oral Glucose Tolerance Test in Healthy Male Subjects
MAR 12 Ahmed Abdulhadi Clin Pharmacokinet. 2010;49(1):53-66. Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole
MAR 19   ASCPT
MAR 26   4th Year Course
APR 2   Holiday
APR 9   No Journal Club
APR 16 Beth Pflug Nature. 2010 Mar 11;464(7286):302-5. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
APR 23 Troy Quigg Bone Marrow Transplant. 2010 Feb;45(2):261-7. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children
APR 30 David Thacker Circulation. 2010 Feb 2;121(4):512-8. Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement
MAY 7 Brain Overholser Circ Heart Fail. 2009 Nov;2(6):664-75. Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure
MAY 14   CTSI Personalized Medicine Seminar
MAY 21   No Journal Club
MAY 28 Lateef Aregbe N Engl J Med. 2009 Jul 9;361(2):123-34. Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
JUN 4 David Haas Obstet Gynecol. 2010 Apr;115(4):765-70. Progesterone Receptor Genotype, Family History, and Spontaneous Preterm Birth
JUN 11 Tom Callaghan N Engl J Med. 2009 Feb 5;360(6):563-72. Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer
JUN 18   No Journal Club
JUN 25 Jamie Renbarger Neuro Oncol. 2010 May 25. Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors
JUL 2   Holiday
JUL 9 Richard Bergstrom J Clin Pharmacol. 2010 Jun;50(6):636-46.

J Clin Pharmacol. 2010 Jun;50(6):623-35.
Multiple-Dose Pharmacokinetics and Pharmacodynamics of Sergliflozin Etabonate, a Novel Inhibitor of Glucose Reabsorption, in Healthy Overweight and Obese Subjects: A Randomized Double-Blind Study

Single-Dose Pharmacokinetics and Pharmacodynamics of Sergliflozin Etabonate, a Novel Inhibitor of Glucose Reabsorption, in Healthy Volunteers and Patients With Type 2 Diabetes Mellitus
JUL 16 Lauren Bell Science. 2010 Jul;329:229-232. An Autophagy-Enhancing Drug Promotes Degradation of Mutant a1-Antitrypsin Z and Reduces Hepatic Fibrosis
JUL 23   No Journal Club
JUL 30 James Tisdale Clin Pharmacol Ther. 2010 Jul;88(1):88-94. Covariate Analysis of QTc and T-Wave Morphology: New Possibilities in the Evaluation of Drugs That Affect Cardiac Repolarization
AUG 6   No Journal Club
AUG 13   No Journal Club
AUG 20 Jason Robarge J Steroid Biochem Mol Biol. 2009 Oct;117(1-3):31-41.

J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):237-41.
Tissue estradiol is selectively elevated in receptor positive breast cancers while tumour estrone is reduced independent of receptor status

Breast cancer aromatase expression evaluated by the novel antibody 677: Correlations to intra-tumor estrogen levels and hormone receptor status
AUG 27   No Journal Club
SEP 3 Sara Quinney Contributions of Human Cytochrome P450 Enzymes to Glyburide Metabolism & Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide
SEP 10   No Journal Club
SEP 17 Raymond Galinsky  
SEP 24 Todd Skaar Genome Res. 2010 Aug;20(8):1020-36. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver (Part I)
OCT 1 Todd Skaar Genome Res. 2010 Aug;20(8):1020-36. Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver (Part II)
OCT 8 David Flockhart Nature. 2010 Aug 5;466(7307):707-13. Biological, clinical and population relevance of 95 loci for blood lipids
OCT 15 David Flockhart Nature. 2010 Aug 5;466(7307):707-13. Biological, clinical and population relevance of 95 loci for blood lipids (continued discussion)
OCT 22 David Thacker Mol Pharmacol. 2010 Nov;78(5):886-94. Regulation of CYP2C19 expression by estrogen receptor alpha. Implications for estrogen dependent inhibition of drug metabolism
OCT 29 Lateef Aregbe J Clin Oncol. 2010 May 20;28(15):2512-9. Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval
NOV 5 Robert Bies J Pharmacokinet Pharmacodyn (2010) 37:475–491. An example of optimal phase II design for exposure response modelling (Part I)
NOV 12 Robert Bies J Pharmacokinet Pharmacodyn (2010) 37:475–491. An example of optimal phase II design for exposure response modelling (Part II)
NOV 19 Ahmed Abdulhadi J Clin Pharmacol. 2010 Aug;50(8):861-72. A Model for Glucose, Insulin, and Beta-Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes
NOV 26   Holiday
DEC 3 Rich Bergstrom Eur J Clin Pharmacol. 2010 Sep 17. Influence of gestational diabetes mellitus on the stereoselective kinetic disposition and metabolism of labetalol in hypertensive patients
DEC 10 Alette Wessels AAPS J. 2010 Jun;12(2):117-29. Quantitative Pharmacology Approach in Alzheimer's Disease: Efficacy Modeling of Early Clinical Data to Predict Clinical Outcome of Tesofensine
DEC 17 Beth Pflug Nature. 2010 Nov 28. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
DEC 24   Holiday
DEC 31   Holiday