| Date |
Presenter |
Journal |
Title |
| JAN 1 |
|
|
No Journal Club |
| JAN 8 |
Anuradha Ramamoorthy |
Drug Metab Dispos. 2009 Oct;37(10):2112-7. |
MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targetingâ–ˇ |
| JAN 15 |
David Flockhart |
J Pharmacol Exp Ther. 2009 Oct 23. |
CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin auto-induction of clearance and maintenance dose |
| JAN 22 |
Jason Robarge |
Exp Gerontol. 2009 Jun-Jul;44(6-7):398-405. |
Immoderate inhibition of estrogen by anastrozole enhances the severity of experimental polyarthritis |
| JAN 29 |
Landry Kamdem Kamdem |
Cancer Res. 2010 Jan 1;70(1):319-28. |
Functional Genetic Polymorphisms in the Aromatase Gene CYP19 Vary the Response of Breast Cancer Patients to Neoadjuvant Therapy with Aromatase Inhibitors |
| FEB 5 |
Xu Han |
Drug Metab Dispos. 2010 Mar;38(3):376-85. |
Identification of Cytochrome P450 Isoforms Involved in the Metabolism of Paroxetine and Estimation of Their Importance for Human Paroxetine Metabolism using a Population-Based Simulator |
| FEB 12 |
Todd Skaar |
BMJ. 2010 Feb 8;340:c693. |
Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study |
| FEB 19 |
James Tisdale |
JAMA. 2008 Oct 15;300(15):1784-92. |
Continuous vs Episodic Prophylactic Treatment With Amiodarone for the Prevention of Atrial Fibrillation: A Randomized Trial |
| FEB 26 |
Robert Bies |
Clin Pharmacol Ther. 2009 Aug;86(2):167-74. |
Elucidation of Relationship Between Tumor Size and Survival in Non-Small-Cell Lung Cancer Patients Can Aid Early Decision Making in Clinical Drug Development |
| MAR 5 |
Lauren Bell |
Clin Pharmacol Ther. 2009 Dec;86(6):644-50. |
Orally Administered Glucagon-Like Peptide-1 Affects Glucose Homeostasis Following an Oral Glucose Tolerance Test in Healthy Male Subjects |
| MAR 12 |
Ahmed Abdulhadi |
Clin Pharmacokinet. 2010;49(1):53-66. |
Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole |
| MAR 19 |
|
|
ASCPT |
| MAR 26 |
|
|
4th Year Course |
| APR 2 |
|
|
Holiday |
| APR 9 |
|
|
No Journal Club |
| APR 16 |
Beth Pflug |
Nature. 2010 Mar 11;464(7286):302-5. |
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer |
| APR 23 |
Troy Quigg |
Bone Marrow Transplant. 2010 Feb;45(2):261-7. |
Influence of GST gene polymorphisms on busulfan pharmacokinetics in children |
| APR 30 |
David Thacker |
Circulation. 2010 Feb 2;121(4):512-8. |
Cytochrome 2C19*17 Allelic Variant, Platelet Aggregation, Bleeding Events, and Stent Thrombosis in Clopidogrel-Treated Patients With Coronary Stent Placement |
| MAY 7 |
Brain Overholser |
Circ Heart Fail. 2009 Nov;2(6):664-75. |
Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure |
| MAY 14 |
|
|
CTSI Personalized Medicine Seminar |
| MAY 21 |
|
|
No Journal Club |
| MAY 28 |
Lateef Aregbe |
N Engl J Med. 2009 Jul 9;361(2):123-34. |
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers |
| JUN 4 |
David Haas |
Obstet Gynecol. 2010 Apr;115(4):765-70. |
Progesterone Receptor Genotype, Family History, and Spontaneous Preterm Birth |
| JUN 11 |
Tom Callaghan |
N Engl J Med. 2009 Feb 5;360(6):563-72. |
Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer |
| JUN 18 |
|
|
No Journal Club |
| JUN 25 |
Jamie Renbarger |
Neuro Oncol. 2010 May 25. |
Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors |
| JUL 2 |
|
|
Holiday |
| JUL 9 |
Richard Bergstrom |
J Clin Pharmacol. 2010 Jun;50(6):636-46.
J Clin Pharmacol. 2010 Jun;50(6):623-35. |
Multiple-Dose Pharmacokinetics and Pharmacodynamics of Sergliflozin Etabonate, a Novel Inhibitor of Glucose Reabsorption, in Healthy Overweight and Obese Subjects: A Randomized Double-Blind Study
Single-Dose Pharmacokinetics and Pharmacodynamics of Sergliflozin Etabonate, a Novel Inhibitor of Glucose Reabsorption, in Healthy Volunteers and Patients With Type 2 Diabetes Mellitus |
| JUL 16 |
Lauren Bell |
Science. 2010 Jul;329:229-232. |
An Autophagy-Enhancing Drug Promotes Degradation of Mutant a1-Antitrypsin Z and Reduces Hepatic Fibrosis |
| JUL 23 |
|
|
No Journal Club |
| JUL 30 |
James Tisdale |
Clin Pharmacol Ther. 2010 Jul;88(1):88-94. |
Covariate Analysis of QTc and T-Wave Morphology: New Possibilities in the Evaluation of Drugs That Affect Cardiac Repolarization |
| AUG 6 |
|
|
No Journal Club |
| AUG 13 |
|
|
No Journal Club |
| AUG 20 |
Jason Robarge |
J Steroid Biochem Mol Biol. 2009 Oct;117(1-3):31-41.
J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):237-41. |
Tissue estradiol is selectively elevated in receptor positive breast cancers while tumour estrone is reduced independent of receptor status
Breast cancer aromatase expression evaluated by the novel antibody 677: Correlations to intra-tumor estrogen levels and hormone receptor status |
| AUG 27 |
|
|
No Journal Club |
| SEP 3 |
Sara Quinney |
|
Contributions of Human Cytochrome P450 Enzymes to Glyburide Metabolism & Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide |
| SEP 10 |
|
|
No Journal Club |
| SEP 17 |
Raymond Galinsky |
|
|
| SEP 24 |
Todd Skaar |
Genome Res. 2010 Aug;20(8):1020-36. |
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver (Part I) |
| OCT 1 |
Todd Skaar |
Genome Res. 2010 Aug;20(8):1020-36. |
Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver (Part II) |
| OCT 8 |
David Flockhart |
Nature. 2010 Aug 5;466(7307):707-13. |
Biological, clinical and population relevance of 95 loci for blood lipids |
| OCT 15 |
David Flockhart |
Nature. 2010 Aug 5;466(7307):707-13. |
Biological, clinical and population relevance of 95 loci for blood lipids (continued discussion) |
| OCT 22 |
David Thacker |
Mol Pharmacol. 2010 Nov;78(5):886-94. |
Regulation of CYP2C19 expression by estrogen receptor alpha. Implications for estrogen dependent inhibition of drug metabolism |
| OCT 29 |
Lateef Aregbe |
J Clin Oncol. 2010 May 20;28(15):2512-9. |
Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval |
| NOV 5 |
Robert Bies |
J Pharmacokinet Pharmacodyn (2010) 37:475–491. |
An example of optimal phase II design for exposure response modelling (Part I) |
| NOV 12 |
Robert Bies |
J Pharmacokinet Pharmacodyn (2010) 37:475–491. |
An example of optimal phase II design for exposure response modelling (Part II) |
| NOV 19 |
Ahmed Abdulhadi |
J Clin Pharmacol. 2010 Aug;50(8):861-72. |
A Model for Glucose, Insulin, and Beta-Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes |
| NOV 26 |
|
|
Holiday |
| DEC 3 |
Rich Bergstrom |
Eur J Clin Pharmacol. 2010 Sep 17. |
Influence of gestational diabetes mellitus on the stereoselective kinetic disposition and metabolism of labetalol in hypertensive patients |
| DEC 10 |
Alette Wessels |
AAPS J. 2010 Jun;12(2):117-29. |
Quantitative Pharmacology Approach in Alzheimer's Disease: Efficacy Modeling of Early Clinical Data to Predict Clinical Outcome of Tesofensine |
| DEC 17 |
Beth Pflug |
Nature. 2010 Nov 28. |
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice |
| DEC 24 |
|
|
Holiday |
| DEC 31 |
|
|
Holiday |