Department of Medicine

Clinical Pharmacology

Friday Journal Club (2011)


Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.

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Date Presenter Journal Title
JAN 7 David Flockhart/Whitney Kramer Arch Intern Med. 2010 Jun 28. Rosiglitazone Revisited: An Updated Meta-analysis of Risk for Myocardial Infarction and Cardiovascular Mortality.
JAN 14 David Haas Obstet Gynecol. 2011 Jan;117(1):41-7. Effect of Injectable and Oral Contraceptives on Glucose and Insulin Levels.
JAN 21 Veronique Michaud PLoS One. 2010 Dec 13;5(12):e15064. VKORC1 Pharmacogenetics and Pharmacoproteomics in Patients on Warfarin Anticoagulant Therapy: Transthyretin Precursor as a Potential Biomarker
JAN 28 David Thacker   Liver disease selectively modulates
cytochrome P450–mediated metabolism
FEB 4 Jessie Lu   Competitive Displacement of Clozapine from Plasma Proteins in Normolipidemic and Hyperlipidemic Plasma Samples: Clinical Implications
FEB 11 Lateef Aregbe   Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer
FEB 18 Jon Duke   Polypharmacoinformatics: Clinical Decision Support in Complex Drug Regimens
MAR 11 Sara Quinney   Determination of a Quantitative Relationship between Hepatic CYP3A5*1/*3 and CYP3A4 Expression for Use in the Prediction of Metabolic Clearance in Virtual Populations
MAR 18 Spring Break    
MAR 25 Eileen Han   Drug-Drug Interactions Among Elderly Patients Hospitalized for Drug Toxicity
APR 8 Rich Bergstrom   Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans
APR 15 Rolf Kreutz   Paraoxonase-1 is a major determinant of clopidogrel efficacy
APR 22 Holiday    
APR 29 Claire Xu   Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model-Based Approaches to Drug–Drug Interaction Trial Design
MAY 13 Tom Callaghan   Disease–Drug–Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis
MAY 20 Todd Skaar   MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
MAY 27 Holiday    
JUN 3 Jason Robarge   An ADIOL-ERb-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation
JUN 10 David Haas   Hypoglycemia in Glyburide-Treated Gestational Diabetes
JUN 17 Veronique Michaud   Cellular localization and functional significance of CYP3A4 in the human epileptic brain
JUL 1 Rob Bies   Tumor growth modeling from clinical trials reveals synergistic anticancer effect of the capecitabine and docetaxel combination in metastatic breast cancer
JUL 8 Desta   Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
JUL 22 Whitney Kramer   Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects and Practical Problems in Interim Analyses, with Particular Regard to Estimation
JUL 29 Jessie Lu   Aromatase Activity and Bone Loss in Men
AUG 5 James Tisdale J Am Coll Cardiol. 2011 Jun 28;58(1):40-4. Reconstituted High-Density Lipoprotein Shortens Cardiac Repolarization
AUG 12 Sara Quinney BMC Syst Biol. 2011 May 6;5(1):66. A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes
AUG 19 No Seminar    
AUG 26 Lang Li   Computer Search for Drug Discovery
SEP 2 Tom Callaghan   Reboxetine & MDMA
SEP 9 Claire Li Atherosclerosis. 2011 Aug;217(2):458-64. Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI
SEP 16 Rolf Kreutz N Engl J Med. 2011 Sep 15;365(11):981-92. Apixaban versus Warfarin in Patients with Atrial Fibrillation
SEP 30 No Seminar    
OCT 7 Lang Li, Eric Sherer, Claire Li, and Sara Quinney N Engl J Med. 2011 Aug 3. Lebrikizumab Treatment in Adults with Asthma
OCT 14 Rob Bies, Tonia Thompson, Heng Zhao, Brian Overholser J Pharmacokinet Pharmacodyn. 2011 Oct;38(5):595-612. Modelling of the outcome of non-inferiority trials by integration of historical data
OCT 21 Jamie Renbarger, Jasper Stevens, Jason Robarge, Jim Tisdale Br J Clin Pharmacol. 2011 Sep;72(3):454-64. Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?
OCT 28 David Jones, David Thacker, Rebecca Lynch, Rolf Kreutz Drug Metab Dispos. 2011 Apr;39(4):703-10. In Vitro Evaluation of Potential Drug-Drug Interactions with Ticagrelor: Cytochrome P450 Reaction Phenotyping, Inhibition, Induction, and Differential Kinetics
NOV 4 David Flockhart, Ingrid Metzger, Whitney Kramer, David Haas J Clin Psychiatry. 2010 Nov;71(11):1482-7. Cytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.
NOV 11 Todd Skaar, Eric Benson, Claire Xu, Rich Bergstrom Molecular Systems Biology 7:513; July 2011, Pages 1-13 A pharmacogenomic method for individualized prediction of drug sensitivity
NOV 18 Eileen Han, Tom Callaghan, Heqaio Dai, and Zereusenay Desta Clinical Pharmacology & Therapeutics 90(4): 575-581. Identification of the Rate-Determining Process in the Hepatic Clearance of Atorvastatin in a Clinical Cassette Microdosing Study
NOV 25 Holiday    
DEC 2 Beth Pflug, Veronique Michaud, Santosh Philips, Anne Nguyen N Engl J Med. 2011 May 26;364(21):1995-2005. Abiraterone and Increased Survival in Metastatic Prostate Cancer
DEC 9 Lang Li, Deshun Lu, and Christina Chung (L) Journal of the American College of Cardiology 2011, Vol. 58, No. 16 Benefit of Early Statin Therapy in Patients With Acute Myocardial Infarction Who Have Extremely Low Low-Density Lipoprotein Cholesterol
DEC 16 Canceled    
DEC 23 Holiday    
DEC 30 Holiday