Department of Medicine

Clinical Pharmacology

Friday Journal Club (2013)


Journal Club meets on Fridays from 9:00 a.m. - 10:00 a.m. in Conference Room (Room W7120) in Wishard Hospital, Myers Building, 7th Floor.

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Date Presenter Journal Title


Todd Skaar, Heqaio Dai, Nadia Falah (L)

Goc et al. BMC Cancer 2012, 12:409 Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis


Ray Galinsky, Mike Ferguson, Eileen Han (L)

N Engl J Med 2012;367:1321-31 Phenotypic Heterogeneity of Genomic Disorders and Rare Copy-Number Variants


Tom Callaghan, Claire Li ,Deshun Lu (L)

N Engl J Med 2013;368:22-33. Cardiovascular Events and Intensity of Treatment in Polycythemia Vera


David Jones, Smitha Marri ,Ingrid Metzger (L)

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Oct. 2011, p. 4569–4574 Effect of the Hepatitis C Virus Protease Inhibitor Telaprevir on the Pharmacokinetics of Amlodipine and Atorvastatin





Beth Pflug, Shripad Chitnis , Claire Xu (L)

Sci Transl Med 5, 169ra10 (2013) DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases


Rob Bies, Nieves Velez de Mendizabal, Heng Zhao (L)

The AAPS Journal, Vol. 13, No. 3, September 2011 Development of a Complex Parent-Metabolite Joint Population Pharmacokinetic Model


David Haas, Tonia Thompson, Costantine Albany (L)

Am J Obstet Gynecol 2011;204:524.e1-4 Pharmacokinetics of oseltamivir in breast milk and maternal plasma





Lang Li, Eric Benson, Heqaio Dai (L)

ONCOLOGY LETTERS 5: 1010-1016, 2013 Inhibition of cancer cell proliferation by midazolam by targeting transient receptor potential melastatin 7


Rolf Kreutz, Nadia Falah, Mike Ferguson (L)

J Clin Oncol 30:1042-1049. Changes in Cardiac Biomarkers During Doxorubicin Treatment of Pediatric Patients With High-Risk Acute Lymphoblastic Leukemia: Associations With Long-Term Echocardiographic Outcomes


Brian Overholser, Eileen Han, Claire Li (L)

Drug Metab. Pharmacokinet. 28 (1): 59-70 (2013) Model-based Dose Selection for Phase III Rivaroxaban Study in Japanese Patients with Non-valvular Atrial Fibrillation


Zeruesenay Desta, Deshun Lu, Smitha Marri (L)



David Thacker, Ingrid Metzger, Troy Quigg (L)

Blood. 2013;121(2):329-338 The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies


David Foster, Shripad Chitnis, Nieves Velez de Mendizabal (L)

PLoS ONE 5(2): e9249. doi:10.1371/journal.pone.0009249 Agent-Based Modeling of Endotoxin-Induced Acute Inflammatory Response in Human Blood Leukocytes


Richard Bergstrom, Jinzhong Liu, Jason Robarge (L)

DOI: 10.1038/ncomms2506 Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo


Brian Decker, Heng Zhao, Tonia Thompson (L)

doifinder/10.1038/clpt.2012.230 Inclusion of Pediatric Samples in an Opt-Out Biorepository Linking DNA to De-Identified Medical Records: Pediatric BioVU


Jamie Renbarger, Costantine Albany, Nadia Falah (L)

Cancer. 2010 September 1; 116(17): 4043–4053. doi:10.1002/cncr.25204. A Phase I and Pharmacodynamic Study of Decitabine in Combination with Carboplatin in Patients with Recurrent, Platinum-Resistant, Epithelial Ovarian Cancer


Supplementary Material(L)

Cancer Res 2012;72:2197-2205 Epigenetic Resensitization to Platinum in Ovarian Cancer


David Flockhart, Heqaio Dai, Eileen Han (L)

N Engl J Med 2013;368:1388-97. DOI: 10.1056/NEJMoa1204471 An fMRI-Based Neurologic Signature of Physical Pain


Sara Quinney, Mike Ferguson, Deshun Lu (L)

doifinder/10.1038/clpt.2012.261 Impact of OATP1B1, MDR1, and CYP3A4 Expression in Liver and Intestine on Interpatient Pharmacokinetic Variability of Atorvastatin in Obese Subjects


Tom Callaghan, Claire Li, Heng Zhao (L)

doi/10.1073/pnas.1304321110 Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis


David Haas, Smitha Marri , Jason Robarge (L)

Am J Obstet Gynecol 2008;198:108.e1-108.e6 Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes  


Todd Skaar, Troy Quigg, Jinzhong Liu (L)

N Engl J Med 2013. DOI: 10.1056/NEJMoa1302369 Nivolumab plus Ipilimumab in Advanced Melanoma


Jim Tisdale, Nieves Velez de Mendizabal, Eric Benson (L)

Sci Transl Med 5, 188ra75 DOI: 10.1126/scitranslmed.3006168 (2013) Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis


Supplementary Material (L)

Sci. Transl. Med. 5, 188ra75 (2013) DOI: 10.1126/scitranslmed.3006168 Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis


David Jones, Shripad Chitnis, Ingrid Metzger (L)

doifinder/10.1038/clpt.2011.178 Evidence of CYP3A Allosterism In Vivo: Analysis of Interaction Between Fluconazole and Midazolam


Supplement Evidence(L)

  Supplement Evidence of CYP3A Allosterism In Vivo Analysis of Intertion Between Fluconazole and Medazolam

July 5



July 12

David Thacker, Tonia Gardner, Costantine Albany (L)

N Engl J Med 2013;369:32-42. DOI: 10.1056/NEJMoa1215637 Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

July 12

Supplementary Appendix(L)

N Engl J Med 2013;369:32-42. DOI: 10.1056/NEJMoa1215637 Supplementary Appendix

July 19

Zeruesenay Desta, Eileen Han, Heqaio Dai (L)

Science 341, 84 (2013); DOI: 10.1126/science.1233606 Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

July 19

Supplementary Material (L)

Science 341, 84 (2013); DOI: 10.1126/science.1233606 Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

July 26

Beth Pflug, Deshun Lu, Mike Ferguson (L)

J Clin Oncol 31:2086-2093. DOI: 10.1200/JCO.2012.45.6228  

August 2

Richard Bergstrom, Nadia Falah, Smitha Marri (L)

Drug Metab Dispos 41:1414–1424, July 2013 Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactionss

August 9

Rolf Kreutz, Rebecca Pierson, Ingrid Metzger (L)

Pharmacogenomics (2013) 14(10), 1167–1178 Impact of pharmacogenetics on CNS side effects related to efavirenz

August 16

Brian Overholser, Jason Robarge, Shripad Chitnis (L)

J Natl Cancer Inst;2013;105:849–859. DOI:10.1093/jnci/djt101 Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer

August 23

Michael Eadon, Anna Schwartz, Heng Zhao (L)

doifinder/10.1038/clpt.2013.121 The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin-Induced Ototoxicity in Children With Cancer

August 30

Rob Bies, Jinzhong Liu, Tonia Gardner (L)

doi:10.1038/clpt.2012.137 Effect of Adherence as Measured by MEMS, Ritonavir Boosting, and CYP3A5 Genotype on Atazanavir Pharmacokinetics in Treatment-Naive HIV-Infected Patients

September 6

Tom Callaghan, Costantine Albany, Nadia Falah (L)

doi10.1016/j.cmet.2013.08.016 FGF21 Mimetic Shows Therapeutic Promise

September 6

Tom Callaghan, Costantine Albany, Nadia Falah (L)

doi10.1016/j.cmet.2013.08.005 The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

September 13



September 20

David Foster, Heqaio Dai, Deshun Lu (L)

doi/10.1038/clpt.2013.92 Gemfibrozil Impairs Imatinib Absorption and Inhibits the CYP2C8-Mediated Formation of Its Main Metabolite

September 27

Lang Li, Mike Ferguson, Rebecca Pierson (L)

Human Molecular Genetics, 2012, Vol. 21, No. 5 1145–1154 doi:10.1093/hmg/ddr543 Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

October 4

Brian Decker, Tyler Shugg, Ingrid Metzger (L)

DOI: 10.1177/1534734613493289 A Functional Single Nucleotide Polymorphism -1562C>T in the Matrix Metalloproteinase-9 Promoter Is Associated With Type 2 Diabetes and Diabetic Foot Ulcers

October 11

Nieves Velez de Mendizabal, Smitha Marri, Eric Benson (L)

PNAS | February 26, 2013 vol. 110 no. 9 3387–3392 Long noncoding RNAs regulate adipogenesis

October 18

David Flockhart, Claire Li, Jinzhong Liu (L)

Clin Pharmacokinet (2013) 52:657–672 DOI 10.1007/s40262-013-0060-y An Integrated Multiple-Analyte Pharmacokinetic Model to Characterize Trastuzumab Emtansine (T-DM1) Clearance Pathways and to Evaluate Reduced Pharmacokinetic Sampling in Patients with HER2-Positive Metastatic Breast Cancer

October 25

Jamie Renbarger, Tonia Gardner, Anna Schwartz (L)

Association of OPRM1 and COMT Single-Nucleotide Polymorphisms With Hospital Length of Stay and Treatment of Neonatal Abstinence Syndrome

November 1

Todd Skaar, Ayman Akil, Costantine Albany (L)

N Engl J Med 2013;368:2266-76. DOI: 10.1056/NEJMoa1300297 Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

November 8

David Haas, Nadia Falah, Heqaio Dai (L)

TICB-994; doi.10.1016/j.tcb.2013.08.003 Mitochondria: gatekeepers of response to chemotherapy

November 15

Avi Patil, Mike Ferguson, Eileen Han (L)

Autoimmune Diseases Volume 2013, Article ID 326258, doi.10.1155/2013/326258 The Role of Simvastatin in the Therapeutic Approach of Rheumatoid Arthritis

November 22

Jim Tisdale, Shripad Chitnis,  Rebecca Pierson (L)

DOI: 10.1161/01.cir.0000437738.63853.7a 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

November 29

No JC - Thanksgiving Holidays


December 6

David Jones, Noha Mourad, Smitha Marri (L)

doi/10.1016/ S0140-6736(13)62151-0 Sofosbuvir and ledipasvir fi xed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial

December 13

Ken Levy, Eric Benson, Claire Li (L)

Pharmacogenomics (2013) 14(16), 2013–2021 Cost–effectiveness of using CYP2C19 genotype to guide selection of clopidogrel or ticagrelor in Australia

December 20

David Thacker, Jinzhong Liu, Ingrid Metzger (L)

Annals of Oncology 21: 1643–1650, 2010 doi:10.1093/annonc/mdq033 Predictive values of hCG clearance for risk of methotrexate resistance in low-risk gestational trophoblastic neoplasias

December 27

No JC - Christmas Holidays