Low-density lipoprotein (LDL) is the major cholesterol carrying lipoprotein in your blood. LDL apheresis is a procedure that takes blood outside the body to remove the LDL-cholesterol and then returns the plasma and blood back to the body. This procedure is used if diet or lipid-lowering drug therapy has not lowered high LDL-cholesterol levels adequately.
Dr. Amale Lteif evaluates patients who might e candidates for LDDL apheresis and overseas this procedure which is performed at Spring Mill Indiana University Infusion Center using the LIPOSORBER system.
Who Qualifies?
| LDL Chol |
Description |
 500 |
Patients with functional homozygous hypercholesterolemia having LDL-cholesterol levels above 500 mg/dl |
| 300 |
Patients with LDL-cholesterol levels > 300 mg/dl. Most patients in this group are severe functional hypercholesterolemic heterozygotes. |
| 200 |
Functional hypercholesterolemic heterozygotes having LDL-cholesterol levels > 200 mg/dl with documented heart disease (CHD). |
Staff
Dr. Amale Lteif
Christine Diene, Lipid Apheresis Technician, Certified Medical Asst.
Publications
- Bosch T, Wendler T
State of the Art of Low-density Lipoprotein Apheresis in the Year 2003. Ther Apher Dial 8:76-79, 2004.
Abstract
- Mellwig KP
Heparin-induced extracorporeal low-density lipoprotein precipitation. Ther Apher Dial 7:365-369, 2003.
Abstract
- Matsuzaki M, Hiramori K, Imaizumi T, Kitabatake A, Hishida H, Nomura M, Fujii T, Sakuma I, Fukami K, Honda T, Ogawa H, Yamagishi M
Intravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: the Low Density Lipoprotein-Apheresis Coronary Morphology and Reserve Trial (LACMART). J Am Coll Cardiol 40:220-227, 2002.
Abstract
- Moriarty PM, Gibson CA, Shih J, Matias MS
C-reactive protein and other markers of inflammation among patients undergoing HELP LDL apheresis. Atherosclerosis 158:495-498, 2001.
Abstract
- Moriarty PM, Gibson CA
Low-density lipoprotein apheresis in the treatment of atherosclerosis and other potential uses. Curr Atheroscler Rep 3:156-162, 2001.
Abstract
- Mabuchi H, Koizumi J, Shimizu M, Kajinami K, Miyamoto S, Ueda K, Takegoshi T
Long-term efficacy of low-density lipoprotein apheresis on coronary heart disease in familial hypercholesterolemia. Hokuriku-FH-LDL-Apheresis Study Group. Am J Cardiol 82:1489-1495, 1998.
Abstract
- Kajinami K, Mabuchi H
Therapeutic effects of LDL apheresis in the prevention of atherosclerosis. Curr Opin Lipidol 10:401-406, 1999.
Abstract