Loren J. Field, PhD
Distinguished Professor
Address
Cancer Research Institute, Room W376
1044 W. Walnut St.
Indianapolis, IN 46202-5254
1044 W. Walnut St.
Indianapolis, IN 46202-5254
Bio
Molecular biologist, Loren Field, PhD, is a professor of medicine, of physiology and biophysics and of pediatrics. He received his PhD at State University of New York at Buffalo and completed his postdoctoral fellowship at Foswell Park Memorial Institute, Buffalo, New York. Prior to his affiliation with Indiana University, Dr. Field was a staff investigator at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Dr. Field and his IU colleagues were the first to show that relatively simple genetic modifications can induce mammalian heart cells to regenerate. His current research is focused on identify genes and molecules that promote heart muscle regeneration by coaxing healthy cells to proliferate. The success of this research would offer the potential for seriously ill patients whose tissue has been damaged by heart attack to "re-grow" their own hearts.
Titles & Appointments
- Distinguished Professor
- Professor of Medicine
- Professor of Anatomy, Cell Biology & Physiology
- Professor of Pediatrics
- Professor of Medicine, Physiology and Biophysics
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Education2000 FEL Postdoctoral Fellowship, Roswell Park Memorial Institute, Buffalo, New York1982 PhD State University of New York at Buffalo1980 MS State University of New York at Buffalo1978 BA State University of New York at Oswego
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Research
Myocardial regeneration, cardiomyocyte cell cycle, cardiac grafts
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PublicationsCardiac Troponin I-Interacting Kinase Affects Cardiomyocyte S-Phase Activity but Not Cardiomyocyte Proliferation.
Reuter SP; Soonpaa MH; Field D; Simpson E; Rubart-von der Lohe M; Lee HK; Sridhar A; Ware SM; Green N; Li X; Ofner S; Marchuk DA; Wollert KC; Field LJ; Circulation 2022 Nov 16Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Reboll MR; Klede S; Taft MH; Cai CL; Field LJ; Lavine KJ; Koenig AL; Fleischauer J; Meyer J; Schambach A; Niessen HW; Kosanke M; van den Heuvel J; Pich A; Bauersachs J; Wu X; Zheng L; Wang Y; Korf-Klingebiel M; Polten F; Wollert KC; Science (New York, N.Y.) 2022 Jun 16A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8.
Tarasov KV; Chakir K; Riordon DR; Lyashkov AE; Ahmet I; Perino MG; Silvester AJ; Zhang J; Wang M; Lukyanenko YO; Qu JH; Barrera MC; Juhaszova M; Tarasova YS; Ziman B; Telljohann R; Kumar V; Ranek M; Lammons J; Bychkov R; de Cabo R; Jun S; Keceli G; Gupta A; Yang D; Aon MA; Adamo L; Morrell CH; Otu W; Carroll C; Chambers S; Paolocci N; Huynh T; Pacak K; Weiss R; Field L; Sollott SJ; Lakatta EG; eLife 2022 Dec 14Cardioprotection vs. regeneration: the case of extracellular vesicle-derived microRNAs.
Wollert KC; Field LJ; Basic research in cardiology 2021 Mar 19Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S Calm1 Mutation.
Tsai WC; Guo S; Olaopa MA; Field LJ; Yang J; Shen C; Chang CP; Chen PS; Rubart M; Circulation 2020 Sep 15HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.
Firulli BA; George RM; Harkin J; Toolan KP; Gao H; Liu Y; Zhang W; Field LJ; Liu Y; Shou W; Payne RM; Rubart-von der Lohe M; Firulli AB; Cardiovascular research 2020 Mar 1Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis.
Anger M; Scheufele F; Ramanujam D; Meyer K; Nakajima H; Field LJ; Engelhardt S; Sarikas A; PloS one 2020 Dec 22Cell Cycle-Mediated Cardiac Regeneration in the Mouse Heart.
Eghbali A; Dukes A; Toischer K; Hasenfuss G; Field LJ; Current cardiology reports 2019 Sep 16Targeted expression of cyclin D2 ameliorates late stage anthracycline cardiotoxicity.
Zhu W; Reuter S; Field LJ; Cardiovascular research 2019 Apr 15Protein phosphatase 5 and the tumor suppressor p53 down-regulate each other's activities in mice.
Wang J; Shen T; Zhu W; Dou L; Gu H; Zhang L; Yang Z; Chen H; Zhou Q; Sánchez ER; Field LJ; Mayo LD; Xie Z; Xiao D; Lin X; Shou W; Yong W; 2018 Sep 27Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish.
González-Rosa JM; Sharpe M; Field D; Soonpaa MH; Field LJ; Burns CE; Burns CG; 2018 Feb 26Absence of Cardiomyocyte Differentiation Following Transplantation of Adult Cardiac-Resident Sca-1<sup>+</sup> Cells Into Infarcted Mouse Hearts.
Soonpaa MH; Lafontant PJ; Reuter S; Scherschel JA; Srour EF; Zaruba MM; Rubart-von der Lohe M; Field LJ; 2018 Dec 182017 Riley Heart Center Symposium on Cardiac Development: Development and Repair of the Ventricular Wall.
Field LJ; Shou W; Markham L; 2018 AugCardiomyocyte proliferation prevents failure in pressure overload but not volume overload.
Toischer K; Zhu W; Hünlich M; Mohamed BA; Khadjeh S; Reuter SP; Schäfer K; Ramanujam D; Engelhardt S; Field LJ; Hasenfuss G; The Journal of clinical investigation 2017 Oct 30Cyclin D2 is sufficient to drive ß cell self-renewal and regeneration.
Tschen SI; Zeng C; Field L; Dhawan S; Bhushan A; Georgia S; Cell cycle (Georgetown, Tex.) 2017 Nov 3Cardiomyocyte Regeneration: A Consensus Statement.
Eschenhagen T; Bolli R; Braun T; Field LJ; Fleischmann BK; Frisén J; Giacca M; Hare JM; Houser S; Lee RT; Marbán E; Martin JF; Molkentin JD; Murry CE; Riley PR; Ruiz-Lozano P; Sadek HA; Sussman MA; Hill JA; Circulation 2017 Jul 6Cardiomyocyte Cell-Cycle Activity during Preadolescence.
Soonpaa MH; Zebrowski DC; Platt C; Rosenzweig A; Engel FB; Field LJ; Cell 2015 Nov 5Cardiac engraftment of genetically-selected parthenogenetic stem cell-derived cardiomyocytes.
Yang T; Rubart M; Soonpaa MH; Didié M; Christalla P; Zimmermann WH; Field LJ; PloS one 2015 Jun 25P53 inhibition exacerbates late-stage anthracycline cardiotoxicity.
Zhu W; Zhang W; Shou W; Field LJ; Cardiovascular research 2014 May 8Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice.
Reuter S; Soonpaa MH; Firulli AB; Chang AN; Field LJ; PloS one 2014 Dec 29Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling.
Scheufele F; Wolf B; Kruse M; Hartmann T; Lempart J; Muehlich S; Pfeiffer AF; Field LJ; Charron MJ; Pan ZQ; Engelhardt S; Sarikas A; Cellular signalling 2013 Nov 9Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Chen H; Zhang W; Sun X; Yoshimoto M; Chen Z; Zhu W; Liu J; Shen Y; Yong W; Li D; Zhang J; Lin Y; Li B; VanDusen NJ; Snider P; Schwartz RJ; Conway SJ; Field LJ; Yoder MC; Firulli AB; Carlesso N; Towbin JA; Shou W; Development (Cambridge, England) 2013 MayParthenogenetic stem cells for tissue-engineered heart repair.
Didié M; Christalla P; Rubart M; Muppala V; Döker S; Unsöld B; El-Armouche A; Rau T; Eschenhagen T; Schwoerer AP; Ehmke H; Schumacher U; Fuchs S; Lange C; Becker A; Tao W; Scherschel JA; Soonpaa MH; Yang T; Lin Q; Zenke M; Han DW; Schöler HR; Rudolph C; Steinemann D; Schlegelberger B; Kattman S; Witty A; Keller G; Field LJ; Zimmermann WH; The Journal of clinical investigation 2013 Feb 22Challenges measuring cardiomyocyte renewal.
Soonpaa MH; Rubart M; Field LJ; Biochimica et biophysica acta 2012 Nov 7Triggered firing and atrial fibrillation in transgenic mice with selective atrial fibrosis induced by overexpression of TGF-ß1.
Choi EK; Chang PC; Lee YS; Lin SF; Zhu W; Maruyama M; Fishbein MC; Chen Z; Rubart-von der Lohe M; Field LJ; Chen PS; Circulation journal : official journal of the Japanese Circulation Society 2012 Mar 22Functional screening of intracardiac cell transplants using two-photon fluorescence microscopy.
Tao W; Soonpaa MH; Field LJ; Chen PS; Firulli AB; Shou W; Rubart M; Pediatric cardiology 2012 Apr 6Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function.
Zhang W; Chen H; Wang Y; Yong W; Zhu W; Liu Y; Wagner GR; Payne RM; Field LJ; Xin H; Cai CL; Shou W; The Journal of biological chemistry 2011 Sep 2The giant danio (D. aequipinnatus) as a model of cardiac remodeling and regeneration.
Lafontant PJ; Burns AR; Grivas JA; Lesch MA; Lala TD; Reuter SP; Field LJ; Frounfelter TD; Anatomical record (Hoboken, N.J. : 2007) 2011 Nov 18FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice.
Maruyama M; Li BY; Chen H; Xu X; Song LS; Guatimosim S; Zhu W; Yong W; Zhang W; Bu G; Lin SF; Fishbein MC; Lederer WJ; Schild JH; Field LJ; Rubart M; Chen PS; Shou W; Circulation research 2011 Mar 3Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.
Knöll R; Linke WA; Zou P; Miocic S; Kostin S; Buyandelger B; Ku CH; Neef S; Bug M; Schäfer K; Knöll G; Felkin LE; Wessels J; Toischer K; Hagn F; Kessler H; Didié M; Quentin T; Maier LS; Teucher N; Unsöld B; Schmidt A; Birks EJ; Gunkel S; Lang P; Granzier H; Zimmermann WH; Field LJ; Faulkner G; Dobbelstein M; Barton PJ; Sattler M; Wilmanns M; Chien KR; Circulation research 2011 Jul 28Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D; Hallett MA; Zhu W; Rubart M; Liu Y; Yang Z; Chen H; Haneline LS; Chan RJ; Schwartz RJ; Field LJ; Atkinson SJ; Shou W; Development (Cambridge, England) 2011 JanRestrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy.
Li D; Liu Y; Maruyama M; Zhu W; Chen H; Zhang W; Reuter S; Lin SF; Haneline LS; Field LJ; Chen PS; Shou W; Human molecular genetics 2011 Aug 31Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes.
Zaruba MM; Zhu W; Soonpaa MH; Reuter S; Franz WM; Field LJ; European heart journal 2011 Aug 17Limitations of conventional approaches to identify myocyte nuclei in histologic sections of the heart.
Ang KL; Shenje LT; Reuter S; Soonpaa MH; Rubart M; Field LJ; Galiñanes M; American journal of physiology. Cell physiology 2010 Mar 24Gene replacement strategies to test the functional redundancy of basic helix-loop-helix transcription factor.
Firulli AB; Firulli BA; Wang J; Rogers RH; Conway SJ; Pediatric cardiology 2010 Feb 14Differential cardiac remodeling in preload versus afterload.
Toischer K; Rokita AG; Unsöld B; Zhu W; Kararigas G; Sossalla S; Reuter SP; Becker A; Teucher N; Seidler T; Grebe C; Preuss L; Gupta SN; Schmidt K; Lehnart SE; Krüger M; Linke WA; Backs J; Regitz-Zagrosek V; Schäfer K; Field LJ; Maier LS; Hasenfuss G; Circulation 2010 Aug 23Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts.
Zaruba MM; Soonpaa M; Reuter S; Field LJ; Circulation 2010 Apr 26Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction.
Hassink RJ; Nakajima H; Nakajima HO; Doevendans PA; Field LJ; Heart (British Cardiac Society) 2009 May 112008 Riley Heart Center Symposium on cardiac development: growth and morphogenesis of the ventricular wall.
Field LJ; Shou W; Caldwell RL; Pediatric cardiology 2009 Apr 2Cell-cycle-based strategies to drive myocardial repair.
Zhu W; Hassink RJ; Rubart M; Field LJ; Pediatric cardiology 2009 Apr 2The cullin7 E3 ubiquitin ligase: a novel player in growth control.
Sarikas A; Xu X; Field LJ; Pan ZQ; Cell cycle (Georgetown, Tex.) 2008 Oct 4Smad7 is required for the development and function of the heart.
Chen Q; Chen H; Zheng D; Kuang C; Fang H; Zou B; Zhu W; Bu G; Jin T; Wang Z; Zhang X; Chen J; Field LJ; Rubart M; Shou W; Chen Y; The Journal of biological chemistry 2008 Oct 24A mouse model for juvenile doxorubicin-induced cardiac dysfunction.
Zhu W; Shou W; Payne RM; Caldwell R; Field LJ; Pediatric research 2008 NovThe CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
Xu X; Sarikas A; Dias-Santagata DC; Dolios G; Lafontant PJ; Tsai SC; Zhu W; Nakajima H; Nakajima HO; Field LJ; Wang R; Pan ZQ; Molecular cell 2008 May 23Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function.
Shen WH; Chen Z; Shi S; Chen H; Zhu W; Penner A; Bu G; Li W; Boyle DW; Rubart M; Field LJ; Abraham R; Liechty EA; Shou W; The Journal of biological chemistry 2008 Mar 7Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.
Snider P; Hinton RB; Moreno-Rodriguez RA; Wang J; Rogers R; Lindsley A; Li F; Ingram DA; Menick D; Field L; Firulli AB; Molkentin JD; Markwald R; Conway SJ; Circulation research 2008 Feb 22Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway.
Zhu W; Soonpaa MH; Chen H; Shen W; Payne RM; Liechty EA; Caldwell RL; Shou W; Field LJ; Circulation 2008 Dec 22Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Yang L; Soonpaa MH; Adler ED; Roepke TK; Kattman SJ; Kennedy M; Henckaerts E; Bonham K; Abbott GW; Linden RM; Field LJ; Keller GM; Nature 2008 Apr 23Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium.
Scherschel JA; Soonpaa MH; Srour EF; Field LJ; Rubart M; Molecular therapy : the journal of the American Society of Gene Therapy 2008 Apr 22Lineage tracing of cardiac explant derived cells.
Shenje LT; Field LJ; Pritchard CA; Guerin CJ; Rubart M; Soonpaa MH; Ang KL; Galiñanes M; PloS one 2008 Apr 16ES cells for troubled hearts.
Rubart M; Field LJ; Nature biotechnology 2007 SepSurvival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts.
Dai W; Field LJ; Rubart M; Reuter S; Hale SL; Zweigerdt R; Graichen RE; Kay GL; Jyrala AJ; Colman A; Davidson BP; Pera M; Kloner RA; Journal of molecular and cellular cardiology 2007 Jul 14Stem cell differentiation: cardiac repair.
Rubart M; Field LJ; Cells, tissues, organs 2007 Dec 20Cardiomyocyte cell cycle activation improves cardiac function after myocardial infarction.
Hassink RJ; Pasumarthi KB; Nakajima H; Rubart M; Soonpaa MH; de la Rivière AB; Doevendans PA; Field LJ; Cardiovascular research 2007 Dec 12Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction.
van Laake LW; Passier R; Monshouwer-Kloots J; Nederhoff MG; Ward-van Oostwaard D; Field LJ; van Echteld CJ; Doevendans PA; Mummery CL; Nature protocols 2007Unraveling the mechanistic basis of mesenchymal stem cell activity in the heart.
Field LJ; Molecular therapy : the journal of the American Society of Gene Therapy 2006 Oct 27Cell-based approaches for cardiac repair.
Rubart M; Field LJ; Annals of the New York Academy of Sciences 2006 OctOverexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
Chen H; Yong W; Ren S; Shen W; He Y; Cox KA; Zhu W; Li W; Soonpaa M; Payne RM; Franco D; Field LJ; Rosen V; Wang Y; Shou W; The Journal of biological chemistry 2006 Jun 23Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.
Dowell JD; Tsai SC; Dias-Santagata DC; Nakajima H; Wang Z; Zhu W; Field LJ; Biochimica et biophysica acta 2006 Dec 15The cardiomyocyte cell cycle.
Lafontant PJ; Field LJ; Novartis Foundation symposium 2006Cardiac regeneration: repopulating the heart.
Rubart M; Field LJ; Annual review of physiology 2006Cardiac repair by embryonic stem-derived cells.
Rubart M; Field LJ; Handbook of experimental pharmacology 2006Cardiomyocyte cell cycle activation ameliorates fibrosis in the atrium.
Nakajima H; Nakajima HO; Dembowsky K; Pasumarthi KB; Field LJ; Circulation research 2005 Nov 23Cell-based cardiac repair: reflections at the 10-year point.
Murry CE; Field LJ; Menasché P; Circulation 2005 Nov 15Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control.
Schroeder M; Niebruegge S; Werner A; Willbold E; Burg M; Ruediger M; Field LJ; Lehmann J; Zweigerdt R; Biotechnology and bioengineering 2005 Dec 30Spontaneous and evoked intracellular calcium transients in donor-derived myocytes following intracardiac myoblast transplantation.
Rubart M; Soonpaa MH; Nakajima H; Field LJ; The Journal of clinical investigation 2004 SepExpression of mutant p193 and p53 permits cardiomyocyte cell cycle reentry after myocardial infarction in transgenic mice.
Nakajima H; Nakajima HO; Tsai SC; Field LJ; Circulation research 2004 May 13Modulation of the cardiomyocyte cell cycle in genetically altered animals.
Field LJ; Annals of the New York Academy of Sciences 2004 MayAllogeneic stem cell-derived "repair unit" therapy and the barriers to clinical deployment.
Strom TB; Field LJ; Ruediger M; Journal of the American Society of Nephrology : JASN 2004 MayHaematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts.
Murry CE; Soonpaa MH; Reinecke H; Nakajima H; Nakajima HO; Rubart M; Pasumarthi KB; Virag JI; Bartelmez SH; Poppa V; Bradford G; Dowell JD; Williams DA; Field LJ; Nature 2004 Mar 21Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice.
Pasumarthi KB; Nakajima H; Nakajima HO; Soonpaa MH; Field LJ; Circulation research 2004 Dec 2Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1.
Verheule S; Sato T; Everett T 4th; Engle SK; Otten D; Rubart-von der Lohe M; Nakajima HO; Nakajima H; Field LJ; Olgin JE; Circulation research 2004 Apr 29Stem cell therapy for ischemic heart disease.
Hassink RJ; Dowell JD; Brutel de la Rivière A; Doevendans PA; Field LJ; Trends in molecular medicine 2003 OctPhysiological coupling of donor and host cardiomyocytes after cellular transplantation.
Rubart M; Pasumarthi KB; Nakajima H; Soonpaa MH; Nakajima HO; Field LJ; Circulation research 2003 May 1Myocyte and myogenic stem cell transplantation in the heart.
Dowell JD; Rubart M; Pasumarthi KB; Soonpaa MH; Field LJ; Cardiovascular research 2003 May 1Cell cycle regulation to repair the infarcted myocardium.
Dowell JD; Field LJ; Pasumarthi KB; Heart failure reviews 2003 JulTwo-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.
Rubart M; Wang E; Dunn KW; Field LJ; American journal of physiology. Cell physiology 2003 Feb 12Scalable production of embryonic stem cell-derived cardiomyocytes.
Zandstra PW; Bauwens C; Yin T; Liu Q; Schiller H; Zweigerdt R; Pasumarthi KB; Field LJ; Tissue engineering 2003 AugAllogeneic stem cells, clinical transplantation and the origins of regenerative medicine.
Strom TB; Field LJ; Ruediger M; Current opinion in immunology 2002 OctCardiomyocyte cell cycle regulation.
Pasumarthi KB; Field LJ; Circulation research 2002 May 31Cardiomyocyte enrichment in differentiating ES cell cultures: strategies and applications.
Pasumarthi KB; Field LJ; Methods in molecular biology (Clifton, N.J.) 2002Cellular therapies for myocardial infarct repair.
Murry CE; Whitney ML; Laflamme MA; Reinecke H; Field LJ; Cold Spring Harbor symposia on quantitative biology 2002Coexpression of mutant p53 and p193 renders embryonic stem cell-derived cardiomyocytes responsive to the growth-promoting activities of adenoviral E1A.
Pasumarthi KB; Tsai SC; Field LJ; Circulation research 2001 May 25Functional abrogation of p53 is required for T-Ag induced proliferation in cardiomyocytes.
Huh NE; Pasumarthi KB; Soonpaa MH; Jing S; Patton B; Field LJ; Journal of molecular and cellular cardiology 2001 AugCell transplantation as future therapy for cardiovascular disease?: A workshop of the National Heart, Lung, and Blood Institute.
Reinlib L; Field L; Circulation 2000 May 9Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene.
Pasumarthi KB; Nakajima H; Nakajima HO; Jing S; Field LJ; Circulation research 2000 May 26Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta(1) transgene in the heart.
Nakajima H; Nakajima HO; Salcher O; Dittiè AS; Dembowsky K; Jing S; Field LJ; Circulation research 2000 Mar 17Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation.
Nakajima H; Nakajima HO; Soonpaa MH; Jing S; Field LJ; Oncogene 2000 Jan 6Simian virus 40 large T antigen binds a novel Bcl-2 homology domain 3-containing proapoptosis protein in the cytoplasm.
Tsai SC; Pasumarthi KB; Pajak L; Franklin M; Patton B; Wang H; Henzel WJ; Stults JT; Field LJ; The Journal of biological chemistry 2000 Feb 4Targeted overexpression of phospholamban to mouse atrium depresses Ca2+ transport and contractility.
Neumann J; Boknik P; DePaoli-Roach AA; Field LJ; Rockman HA; Kobayashi YM; Kelley JS; Jones LR; Journal of molecular and cellular cardiology 1998 OctLone atrial fibrillation and autoantibodies: cause versus effect.
Field LJ; Journal of cardiovascular electrophysiology 1998 JunSurvey of studies examining mammalian cardiomyocyte DNA synthesis.
Soonpaa MH; Field LJ; Circulation research 1998 Jul 13Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product.
Pajak L; Jin F; Xiao GH; Soonpaa MH; Field LJ; Yeung RS; The American journal of physiology 1997 SepCyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice.
Soonpaa MH; Koh GY; Pajak L; Jing S; Wang H; Franklin MT; Kim KK; Field LJ; The Journal of clinical investigation 1997 Jun 1Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts.
Soonpaa MH; Field LJ; The American journal of physiology 1997 JanGenesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.
Sutton J; Costa R; Klug M; Field L; Xu D; Largaespada DA; Fletcher CF; Jenkins NA; Copeland NG; Klemsz M; Hromas R; The Journal of biological chemistry 1996 Sep 20Mouse RAD50 has limited epitopic homology to p53 and is expressed in the adult myocardium.
Kim KK; Daud AI; Wong SC; Pajak L; Tsai SC; Wang H; Henzel WJ; Field LJ; The Journal of biological chemistry 1996 Nov 15Cardiomyocyte DNA synthesis and binucleation during murine development.
Soonpaa MH; Kim KK; Pajak L; Franklin M; Field LJ; The American journal of physiology 1996 NovGenetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
Klug MG; Soonpaa MH; Koh GY; Field LJ; The Journal of clinical investigation 1996 Jul 1Stable fetal cardiomyocyte grafts in the hearts of dystrophic mice and dogs.
Koh GY; Soonpaa MH; Klug MG; Pride HP; Cooper BJ; Zipes DP; Field LJ; The Journal of clinical investigation 1995 OctOverexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells.
Hassankhani A; Steinhelper ME; Soonpaa MH; Katz EB; Taylor DA; Andrade-Rozental A; Factor SM; Steinberg JJ; Field LJ; Federoff HJ; Developmental biology 1995 MayPotential approaches for myocardial regeneration.
Soonpaa MH; Daud AI; Koh GY; Klug MG; Kim KK; Wang H; Field LJ; Annals of the New York Academy of Sciences 1995 Mar 27Blood pressure and fluid-electrolyte balance in ANF-transgenic mice on high- and low-salt diets.
Veress AT; Chong CK; Field LJ; Sonnenberg H; The American journal of physiology 1995 JulTargeted expression of transforming growth factor-beta 1 in intracardiac grafts promotes vascular endothelial cell DNA synthesis.
Koh GY; Kim SJ; Klug MG; Park K; Soonpaa MH; Field LJ; The Journal of clinical investigation 1995 JanLength dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C.
McDonald KS; Field LJ; Parmacek MS; Soonpaa M; Leiden JM; Moss RL; The Journal of physiology 1995 Feb 15DNA synthesis and multinucleation in embryonic stem cell-derived cardiomyocytes.
Klug MG; Soonpaa MH; Field LJ; The American journal of physiology 1995 DecDevelopmental expression of p107 mRNA and evidence for alternative splicing of the p107 (RBL1) gene product.
Kim KK; Soonpaa MH; Wang H; Field LJ; Genomics 1995 Aug 10Strategies for myocardial repair.
Koh GY; Soonpaa MH; Klug MG; Field LJ; Journal of interventional cardiology 1995 AugCloning, developmental expression, and evidence for alternative splicing of the murine tuberous sclerosis (TSC2) gene product.
Kim KK; Pajak L; Wang H; Field LJ; Cellular & molecular biology research 1995Tumor suppressor gene expression during normal and pathologic myocardial growth.
Kim KK; Soonpaa MH; Daud AI; Koh GY; Kim JS; Field LJ; The Journal of biological chemistry 1994 Sep 9Proximal tubular function in transgenic mice overexpressing atrial natriuretic factor.
Sonnenberg H; Honrath U; Chong CK; Field LJ; Veress AT; Canadian journal of physiology and pharmacology 1994 OctAssessment of donor bone marrow cell-derived chimerism in transplantation tolerance using transgenic mice.
Smith JP; Kasten-Jolly J; Field LJ; Thomas JM; Transplantation 1994 Aug 15Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium.
Soonpaa MH; Koh GY; Klug MG; Field LJ; Science (New York, N.Y.) 1994 Apr 1Hemodynamics in transgenic mice with overexpression of atrial natriuretic factor.
Barbee RW; Perry BD; Ré RN; Murgo JP; Field LJ; Circulation research 1994 AprAssessment of cardiomyocyte DNA synthesis during hypertrophy in adult mice.
Soonpaa MH; Field LJ; The American journal of physiology 1994 AprBlood pressure regulation in ANF-transgenic mice: role of angiotensin and vasopressin.
Lichardus B; Veress AT; Field LJ; Sonnenberg H; Physiological research / Academia Scientiarum Bohemoslovaca 1994Differentiation and long-term survival of C2C12 myoblast grafts in heart.
Koh GY; Klug MG; Soonpaa MH; Field LJ; The Journal of clinical investigation 1993 SepSkeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice.
Metzger JM; Parmacek MS; Barr E; Pasyk K; Lin WI; Cochrane KL; Field LJ; Leiden JM; Proceedings of the National Academy of Sciences of the United States of America 1993 Oct 1Atrial natriuretic factor and transgenic mice.
Koh GY; Klug MG; Field LJ; Hypertension 1993 OctIdentification of SV40 large T-antigen-associated proteins in cardiomyocytes from transgenic mice.
Daud AI; Lanson NA Jr; Claycomb WC; Field LJ; The American journal of physiology 1993 MayLong-term survival of AT-1 cardiomyocyte grafts in syngeneic myocardium.
Koh GY; Soonpaa MH; Klug MG; Field LJ; The American journal of physiology 1993 MayResidues 2-25 of phospholamban are insufficient to inhibit Ca2+ transport ATPase of cardiac sarcoplasmic reticulum.
Jones LR; Field LJ; The Journal of biological chemistry 1993 Jun 5Cardiopulmonary responses to chronic hypoxia in transgenic mice that overexpress ANP.
Klinger JR; Petit RD; Curtin LA; Warburton RR; Wrenn DS; Steinhelper ME; Field LJ; Hill NS; Journal of applied physiology (Bethesda, Md. : 1985) 1993 JulSpontaneous activity in transgenic mouse heart: comparison of primary atrial tumor with cultured AT-1 atrial myocytes.
Kline RP; Sorota S; Dresdner KP; Steinhelper ME; Lanson NA Jr; Wit AL; Claycomb WC; Field LJ; Journal of cardiovascular electrophysiology 1993 DecTransgenic mice in cardiovascular research.
Field LJ; Annual review of physiology 1993Gene expression and atrial natriuretic factor processing and secretion in cultured AT-1 cardiac myocytes.
Lanson NA Jr; Glembotski CC; Steinhelper ME; Field LJ; Claycomb WC; Circulation 1992 MayCardiomyocyte proliferation in mice expressing alpha-cardiac myosin heavy chain-SV40 T-antigen transgenes.
Katz EB; Steinhelper ME; Delcarpio JB; Daud AI; Claycomb WC; Field LJ; The American journal of physiology 1992 JunAssignment of the angiogenin gene to mouse chromosome 14 using a rapid PCR-RFLP mapping technique.
Steinhelper ME; Field LJ; Genomics 1992 JanEffect of potassium infusion on renal function in ANF-transgenic mice.
Veress AT; Field LJ; Steinhelper ML; Sonnenberg H; Clinical and investigative medicine. Me´decine clinique et experimentale 1992 DecSegregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
Rockman HA; Ross RS; Harris AN; Knowlton KU; Steinhelper ME; Field LJ; Ross J Jr; Chien KR; Proceedings of the National Academy of Sciences of the United States of America 1991 Sep 15Kidney function in ANF-transgenic mice: effect of blood volume expansion.
Field LJ; Veress AT; Steinhelper ME; Cochrane K; Sonnenberg H; The American journal of physiology 1991 JanEngineering the cardiovascular system. Blood pressure regulation.
Steinhelper ME; Cochrane KL; Field LJ; Annals of the New York Academy of Sciences 1991 Dec 27Morphological characterization of cardiomyocytes isolated from a transplantable cardiac tumor derived from transgenic mouse atria (AT-1 cells).
Delcarpio JB; Lanson NA Jr; Field LJ; Claycomb WC; Circulation research 1991 DecHypotension in transgenic mice expressing atrial natriuretic factor fusion genes.
Steinhelper ME; Cochrane KL; Field LJ; Hypertension 1990 SepProliferation in vivo and in culture of differentiated adult atrial cardiomyocytes from transgenic mice.
Steinhelper ME; Lanson NA Jr; Dresdner KP; Delcarpio JB; Wit AL; Claycomb WC; Field LJ; The American journal of physiology 1990 DecCardiac tumors and dysrhythmias in transgenic mice.
Steinhelper ME; Field LJ; Toxicologic pathology 1990Allele-specific expression of the murine Ren-1 genes.
Fabian JR; Field LJ; McGowan RA; Mullins JJ; Sigmund CD; Gross KW; The Journal of biological chemistry 1989 Oct 15Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice.
Field LJ; Science (New York, N.Y.) 1988 Feb 26Conserved regions in defective interfering viral double-stranded RNAs from a yeast virus.
Lee M; Pietras DF; Nemeroff ME; Corstanje BJ; Field LJ; Bruenn JA; Journal of virology 1986 MayRen-1 and Ren-2 loci are expressed in mouse kidney.
Field LJ; Gross KW; Proceedings of the National Academy of Sciences of the United States of America 1985 SepExpression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions.
Field LJ; Philbrick WM; Howles PN; Dickinson DP; McGowan RA; Gross KW; Molecular and cellular biology 1984 NovTwo Ustilago maydis viral dsRNAs of different size code for the same product.
Field LJ; Bruenn JA; Chang TH; Pinhasi O; Koltin Y; Nucleic acids research 1983 May 11Cloning of cDNA to a yeast viral double-stranded RNA and comparison of three viral RNAs.
Bobek LA; Bruenn JA; Field LJ; Gross KW; Gene 1982 SepThere are at least two yeast viral double-stranded RNAs of the same size: an explanation for viral exclusion.
Field LJ; Bobek LA; Brennan VE; Reilly JD; Bruenn JA; Cell 1982 Nov -
Clinical Interests
Cardiac tumorigenesis, tuberous sclerosis, heart failure, heart repair, myocyte regeneration
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AwardsOrg: Indiana University
Desc: Bicentennial Medal
Scope: University
Date: 2020-07-14
Org: Indiana University
Desc: Distinguished Professor
Scope: University
Date: 2020-07-14
Org: IUPUI
Desc: Glenn W. Irwin Research Scholar Award
Scope: University
Date: 2015-04-19
Research Labs
Faculty research at IU School of Medicine is transforming health. Details about the medical research being conducted in faculty labs throughout IU School of Medicine are available in the Research section of this site.