Michael Rubart-von der Lohe, MD

EDUCATION:

1977-1984 Medical School, University of BOnn, Germany

1984 - 1985                 Military Service, Institute of Naval Medicine, Kiel, Germany

1985 - 1990                 Department of Cardiology, Technical University of Aachen, Aachen, Germany

1991- 1992                  Research Fellow at the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN

1992 - 1993                 Department of Internal Medicine, Community Hospital Düren, Germany

1993 - 1994           Department of Pharmacology, University of Vermont, Burlington, VT

ACADEMIC APPOINTMENTS:

1994 - 2005         Assistant Scientist, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN

2005 - 2014        Assistant Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN

2005 - 2014          Assistant Professor of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN (secondary appointment)

2014 - present     Research Assistant Professor of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN

HONORS AND AWARDS:

 1991 - 1992                 Postdoctoral Fellowship, Max-Kade Foundation, New York, NY

Rubart M, Breull W, Hahn N: Regional metabolic rate of exogenous glucose in the isoprenaline and dobutamine stimulated myocardium as estimated by the 2-desoxy-D[1-14C]glucose method. Nuclear Medicine and Biology 1991;18:157-166.

Rubart M, Pressler ML, Pride HP, Zipes DP: Electrophysiological mechanisms in a canine model of erythromycin associated long - QT syndrome. Circulation 1993; 88 [part 1]:1832-1844.

Rubart M, Patlak JB, Nelson MT: Ca⁺⁺ currents in cerebral artery smooth muscle cells of rat at physiological Ca⁺⁺ concentrations. J Gen Physiol, 1996; 107: 459-472.

Miyata A, Dowell JD, Zipes DP, Rubart M.  [K⁺]_o Accumulation in Canine Right Atria During Atrial Tachycardia and Fibrillation: Electrophysiological Consequences. Am J Physiol Heart Circ Physiol 283:H506-H517, 2002.

Rubart M, Pasumarthi KBS, Nakajima H, Soonpaa M, Nakajima HO, Field LJ. Physiologic coupling of donor and host cardiomyocytes following cellular transplantation (with accompanying commentary by A. Kléber). Circ Res 92:1217-1224, 2003.

Scherschel JA, Soonpaa MH, Srour E, Field LJ, Rubart M. Adult Bone Marrow-Derived Cells Do Not Acquire Functional Attributes of Cardiomyocytes Upon Transplantation Into Peri-Infarct Myocardium (with accompanying commentary by P. Menasché). Molecular Therapy, 2008;16(6):1129-1137.

Bu G, Adams H, Berbari EJ, Rubart M. Uniform action potential repolarization within the sarcolemma of in situ ventricular cardiomyocytes. Biophysical Journal, 2009;96: 2532–2546.

Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Wen T, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J Clin Invest 2013;123:1285-98.

Freeman K, Sun H, Tao W, Mark H. Soonpaa, Rubart M. In situ three-dimensional reconstruction of mouse heart sympathetic innervation by two-photon excitation fluorescence imaging. Journal of Neuroscience Methods, 2013;221C:48-61.

Rubart M, Tao W, Lu X, Conway SJ, Reuter SP, Lin SF, Soonpaa MH. Electrical coupling between ventricular myocytes and myofibroblasts in the infarcted mouse heart. Cardiovasc Res, 2018;114(3):389-400.

Ko JS, Hassel J, Celestino-Soper P, Lynnes TC, Tisdale JE, Zheng JJ, Taylor SE, Foroud T, Murray MD, Kovacs RJ, Li X, Lin SF, PhD, Chen Z, Vatta M, Chen PS, Rubart M. Ondansetron Blocks Wildtype and p.F503L Variant Small Conductance Calcium Activated Potassium Channels. Am J Physiol, Heart and Circul Physiol, 2018 Apr 20. doi: 10.1152/ajpheart.00479.2017.

Soonpaa MH, Lafontant PJ, Reuter S, Scherschel JA, Srour EF, Zaruba MM, Rubart-von der Lohe M, Field LJ. Absence of cardiomyocyte differentiation following transplantation of adult cardiac resident Sca-1⁺ cells into infarcted mouse hearts. Circulation, 2018; 138(25):2963-2966.

Tsai W, Guo S, Olaopa MA, Field LJ, Yang J, Shen C, Chang CP, Chen PS, Rubart M. Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S Calm1 Mutation. Circulation, 2020;142(20):1937-1955. doi: 10.1161/CIRCULATIONAHA.120.046450.

Guo S, Chen Z, Chen PS, Rubart M. Inhibition of small-conductance, Ca²⁺ -activated K⁺ current by ondansetron. Front Pharmacol. 2021 Apr 22;12:651267.