Bio
Key Publications
Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE, Naidu SR. J Biol Chem. 2016 Oct 14;291(42):21869-21879. Epub 2016 Aug 18. Highlighted by JBC virtual issue on Cancer: https://www.jbc.org/cancer
Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2. Shankar Babu M, Mahanta S, Lakhter AJ, Hato T, Paul S, Naidu SR. PLoS One. February 2, 2018 https://doi.org/10.1371/journal.pone.0191419
Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma. Lakhter AJ, Hamilton J, Dagher PC, Mukkamala S, Hato T, Dong XC, Mayo LD, Harris RA, Shekhar A, Ivan M, Brustovetsky N, Naidu SR. Oncotarget. 2014 Dec 30;5(24):12694-703.
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. Lakhter AJ, Sahu RP, Sun Y, Kaufmann WK, Androphy EJ, Travers JB, Naidu SR. J Invest Dermatol. 2013 Sep;133(9):2247-54. doi: 10.1038/jid.2013.56. Epub 2013 Jan 31. Commentary: J Invest Dermatol. 2013. 133(9): p. 2133-5
Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects.
Leukemia. Oct., 2021 *Corresponding author.
Titles & Appointments
- Assistant Research Professor of Medicine
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Education
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Research
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Awards