References for Cytochrome P450 Drug Interaction Table: 2C8
These pages contain all the literature citations referenced in the Cytochrome P450 Drug Interaction Tables (both the extensive research-oriented table and the concise clinical table). Most of these citations are hyperlinks, which bring up the abstract in the NLM's PubMed database.
Click on the [ PubMed ] link after the drug name to perform a live MedLINE search of articles possibly related to that drug and Cytochrome P450.
Entries are organized by mode of activity (substrate, inhibitor, inducer) within specific isoform. You can quickly branch to a section by clicking on the appropriate link here:
1A2 | 2B6 | 2C8 | 2C19 | 2C9 | 2D6 | 2E1 | 3A457
Use Ctrl-F to find all or part of the name or word for which you are searching.
cerivastatin: PubMed
Clinical pharmacokinetics of cerivastatin.
Muck W.
Clin Pharmacokinet. 2000 Aug;39(2):99-116.
Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes.
Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ.
Drug Metab Dispos. 2002 Dec;30(12):1352-6.
montelukast: PubMed
Selective inhibition of human cytochrome P4502C8 by montelukast.
Walsky RL, Obach RS, Gaman EA, Gleeson JP, Proctor WR.
Drug Metab Dispos. 2005 Mar;33(3):413-8.
paclitaxel: PubMed
Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants.
Vaclavikova R, Horsky S, Simek P, Gut I.
Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):200-9. Epub 2003 Aug 14.
repaglinide: PubMed
CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide.
Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT.
Br J Clin Pharmacol. 2003 Sep;56(3):305-14.
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide.
Niemi M, Leathart JB, Neuvonen M, Backman JT, Daly AK, Neuvonen PJ.
Clin Pharmacol Ther. 2003 Oct;74(4):380-7.
rosiglitazone: PubMed
Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.
Baldwin SJ, Clarke SE, Chenery RJ.
Br J Clin Pharmacol. 1999 Sep;48(3):424-32.
torsemide: PubMed
The xenobiotic inhibitor profile of cytochrome P4502C8.
Ong CE, Coulter S, Birkett DJ, Bhasker CR, Miners JO.
Br J Clin Pharmacol. 2000 Dec;50(6):573-80.
| » GEMFIBROZIL |
[ PubMed ] |
| Article | Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. |
| Authors | Wang JS, Neuvonen M, Wen X, Backman JT, Neuvonen PJ. |
| Link to Abstract | Drug Metab Dispos. 2002 Dec;30(12):1352-6.
|
| Article | Gemfibrozil greatly increases plasma concentrations of cerivastatin. |
| Authors | Backman JT, Kyrklund C, Neuvonen M, Neuvonen PJ. |
| Link to Abstract | Clin Pharmacol Ther. 2002 Dec;72(6):685-91.
|
| Article | Gemfibrozil considerably increases the plasma concentrations of rosiglitazone. |
| Authors | Niemi M, Backman JT, Granfors M, Laitila J, Neuvonen M, Neuvonen PJ. |
| Link to Abstract | Diabetologia. 2003 Oct;46(10):1319-23.
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| Info | www.rxlist.com |
| » TRIMETHOPRIM |
[ PubMed ] |
| Article | Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. |
| Authors | Wen X, Wang JS, Backman JT, Laitila J, Neuvonen PJ. |
| Link to Abstract | Drug Metab Dispos. 2002 Jun;30(6):631-5.
|
| Article | Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone. |
| Authors | Niemi M, Backman JT, Neuvonen PJ. |
| Link to Abstract | Clin Pharmacol Ther. 2004 Sep;76(3):239-49.
|
| Article | The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects. |
| Authors | Hruska MW, Amico JA, Langaee TY, Ferrell RE, Fitzgerald SM, Frye RF. |
| Link to Abstract | Br J Clin Pharmacol. 2005 Jan;59(1):70-9.
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| Article | The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects.. |
| Authors | Niemi M, Kajosaari LI, Neuvonen M, Backman JT, Neuvonen PJ. |
| Link to Abstract | Br J Clin Pharmacol. 2004 Apr;57(4):441-7.
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| Info | www.rxlist.com |
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