References for Cytochrome P450 Drug Interaction Table: 3A4,5,7
These pages contain all the literature citations referenced in the Cytochrome P450 Drug Interaction Tables (both the extensive research-oriented table and the concise clinical table). Most of these citations are hyperlinks, which bring up the abstract in the NLM's PubMed database.
Click on the [ PubMed ] link after the drug name to perform a live MedLINE search of articles possibly related to that drug and Cytochrome P450.
Entries are organized by mode of activity (substrate, inhibitor, inducer) within specific isoform. You can quickly branch to a section by clicking on the appropriate link here:
1A2 | 2B6 | 2C8 | 2C19 | 2C9 | 2D6 | 2E1 | 3A457
Use Ctrl-F to find all or part of the name or word for which you are searching.
| » APREPITANT |
[ PubMed ] |
| Article | Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. |
| Authors | Shadle CR, Lee Y, Majumdar AK, Petty KJ, Gargano C, Bradstreet TE, Evans JK, Blum RA. |
| Link | J Clin Pharmacol. 2004 Mar;44(3):215-23.
|
| Article | Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe. |
| Authors | Majumdar AK, McCrea JB, Panebianco DL, Hesney M, Dru J, Constanzer M, Goldberg MR, Murphy G, Gottesdiener KM, Lines CR, Petty KJ, Blum RA. |
| Link | Clin Pharmacol Ther. 2003 Aug;74(2):150-6.
|
| Article | Aprepitant: a novel antiemetic for chemotherapy-induced nausea and vomiting. |
| Authors | Massaro AM, Lenz KL |
| Link | Ann Pharmacother. 2005 Jan;39(1):77-85. |
| Info | www.rxlist.com |
| » CILOSTAZOL |
[ PubMed ] |
| Article | Cilostazol: a review of its use in intermittent claudication. |
| Authors | Chapman TM, Goa KL. |
| Link | Am J Cardiovasc Drugs. 2003;3(2):117-38. |
| Info | www.rxlist.com |
| » CLARITHROMYCIN |
[ PubMed ] |
| Article | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. |
| Authors | Rodrigues AD, Roberts EM, Mulford DJ, Yao Y, Ouellet D |
| Link | Metab Dispos 1997 May;25(5):623-630
|
| Article | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. |
| Authors | Rodrigues AD, Roberts EM, Mulford DJ, Yao Y, Ouellet D |
| Link | Metab Dispos 1997 May;25(5):623-630
|
| Info | www.rxlist.com |
| » CYCLOSPORINE |
[ PubMed ] |
| Article | The role of cytochromes P-450 in cyclosporine metabolism. |
| Authors | Watkins PB |
| Link | Am Acad Dermatol 1990 Dec;23(6 Pt 2):1301-1309
|
| Article | Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. |
| Authors | Kronbach T, Fischer V, Meyer UA |
| Link | Clin Pharmacol Ther 1988 Jun;43(6):630-635
|
| Article | Exacerbation of cyclosporine toxicity by concomitant administration of erythromycin. |
| Authors | Jensen CW, Flechner SM, Van Buren CT, Frazier OH, Cooley DA, Lorber MI, Kahan BD |
| Link | Transplantation 1987 Feb;43(2):263-270
|
| Article | Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients. |
| Authors | Turgeon DK, Normolle DP, Leichtman AB, Annesley TM, Smith DE, Watkins PB |
| Link | Clin Pharmacol Ther 1992 Nov;52(5):471-478
|
| Info | |
| » DIAZEPAM |
[ PubMed ] |
| Article | Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate-concentration-dependent manner. |
| Authors | Yasumori T, Nagata K, Yang SK, Chen L-S, Murayama N, Yamazoe Y, Kato R |
| Link | Pharmacogenetics 1993;3:291-301 |
| Info | www.rxlist.com |
| » FELODIPINE |
[ PubMed ] |
| Article | Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. |
| Authors | Lown KS, Bailey DG, Fontana RJ, Janardan SK, Adair CH, Fortlage LA, Brown MB, Guo W, Watkins PB |
| Link | Clin Invest 1997 May 15;99(10):2545-2553
|
| Article | Erythromycin-felodipine interaction: magnitude, mechanism, and comparison with grapefruit juice. |
| Authors | Bailey DG, Bend JR, Arnold JM, Tran LT, Spence JD |
| Link | Clin Pharmacol Ther 1996 Jul;60(1):25-33
|
| Article | Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. |
| Authors | Guengerich FP, Brian WR, Iwasaki M, Sari MA, Baarnhielm C, Berntsson P |
| Link | J Med Chem 1991 Jun;34(6):1838-1844
|
| Info | www.rxlist.com |
| » INDINAVIR |
[ PubMed ] |
| Article | Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir. |
| Authors | Koudriakova T, Iatsimirskaia E, Utkin I, Gangl E, Vouros P, Storozhuk E, Orza D, Marinina J, Gerber N |
| Link | Drug Metab Dispos 1998 Jun;26(6):552-561 |
| Info | |
| » IRINOTECAN |
[ PubMed ] |
| Article | Modulation of irinotecan metabolism by ketoconazole. |
| Authors | Kehrer DF, Mathijssen RH, Verweij J, De Bruijn P, Sparreboom A. |
| Link | J Clin Oncol 2002 Jul 15;20(14):3122-9
|
| Article | Metabolism of irinotecan (CPt-11) by CYP3A4 and CYP3a5 in humans. |
| Authors | Santos A, Zanetta S, Cresteil T, Deroussent A, Pein F, Raymond E, Vernillet L, Risse ML, Boige V, Gouyette A, Vassal G. |
| Link | Clin Cancer Res. 2000 May;6(5):2012-20.
|
| Article | A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4. |
| Authors | Sai K, Kaniwa N, Ozawa S, Sawada JI. |
| Link | Drug Metab Dispos 2001 Nov;29(11):1505-13.
|
| Info | |
Drug
Metab Dispos 1997 Dec;25(12):1347-1353
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone
in human liver microsomes.
Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, Menez
JF
Chem
Res Toxicol 1996 Mar;9(2):365-373
midazolam: Info
PubMed
Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.
Gorski JC, Hall SD, Jones DR, VandenBranden M, Wrighton SA
Biochem
Pharmacol 1994;47(9):1643-1653
nateglinide: PubMed
nelfinavir: Info
PubMed
nifedipine: Info
PubMed
nisoldipine: Info
PubMed
Effect of grapefruit juice and naringen on nisoldipine
pharmacokinetics.
Bailey DG, Arnold MO, Strong A, Munoz C,Spence JD
Clin
Pharmacol Ther 1993;54(6):589-594
nitrendipine: Info
PubMed
odanestron (in part): Info
PubMed
Multiple forms of cytochrome P450 are involved in the metabolism of
ondansetron in humans.
Dixon CM, Colthup PV, Serabjit-Singh CJ, Kerr BM, Boehlert CC, Park GR, Tarbit
MH
Drug
Metab Dispos 1995 Nov;23(11):1225-1230
Oxcarbazepine:
PubMed
Spotlight on oxcarbazepine in epilepsy.
Bang LM, Goa KL.
CNS Drugs. 2004;18(1):57-61.
pimozide: Info
PubMed
Identification and characterization of human cytochrome P450 isoforms
interacting with pimozide.
Desta Z, Kerbusch T, Soukhova N, Richard E, Ko JW, Flockhart
DA
J
Pharmacol Exp Ther 1998 May;285(2):428-37
NOT pravastatin: Info
PubMed
Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.
Neuvonen PJ, Kantola T, Kivisto KT
Clin
Pharmacol Ther 1998 Mar;63(3):332-341
Biotransformation of pravastatin sodium in humans.
Everett DW, Chando TJ, Didonato GC, Singhvi SM, Pan HY, Weinstein SH
Drug
Metab Dispos 1991 Jul;19(4):740-748
progesterone: Info
PubMed
propranolol: Info
PubMed
The influence of diltiazem versus cimetidine on propranolol
metabolism.
Tateishi T, Ohashi K, Fujimura A, Ebihara A
J.
Clin. Pharm. 32:1099-1104, 1992
quinidine: PubMed
CO binding kinetics of human cytochrome P450 3A4. Specific interaction
of substrates with kinetically distinguishable conformers.
Koley AP, Buters JT, Robinson RC, Markowitz A, Friedman FK
J
Biol Chem 1995 Mar 10;270(10):5014-5018
quinine: PubMed
risperidone:
Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects.
Huang ML, Van Peer A, Woestenborghs R, De Coster R, Heykants J, Jansen AA, Zylicz Z, Visscher HW, Jonkman JH.
Clin Pharmacol Ther. 1993 Sep;54(3):257-68.
ritonavir: Info
PubMed
Metabolism of the human immunodeficiency virus protease inhibitors indinavir
and ritonavir by human intestinal microsomes and expressed cytochrome
P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by
ritonavir.
Koudriakova T, Iatsimirskaia E, Utkin I, Gangl E, Vouros P, Storozhuk E,
Orza D, Marinina J, Gerber N
Drug
Metab Dispos 1998 Jun;26(6):552-561
NOT rosuvastatin:
PubMed
Lack of effect of ketoconazole on the pharmacokinetics of rosuvastatin in healthy subjects.
Cooper KJ, Martin PD, Dane AL, Warwick MJ, Raza A, Schneck DW.
Br J Clin Pharmacol. 2003 Jan;55(1):94-9.
salmeterol: Info
PubMed
The aliphatic oxidation of salmeterol to alpha-hydroxy salmeterol in human
liver microsomes is catalyzed bt cytochrome P450 3A.
Manchee GR, Eddershaw PJ, Ranshaw LE, Herriott D, Park GR, Bayliss MK, Tarbit
MH
Drug
Metab Dispos 1996;24(5): 555-559
saquinavir: Info
PubMed
Selective biotransformation of the human immunodeficiency virus protease
inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential
contribution to high first-pass metabolism.
Fitzsimmons ME, Collins JM
Drug
Metab Dispos 1997 Feb;25(2):256-266
Protease inhibitors in patients with HIV disease. Clinically important
pharmacokinetic considerations.
Barry M, Gibbons S, Back D, Mulcahy F
Clin
Pharmacokinet 1997 Mar;32(3):194-209
sildenafil: Info
PubMed
The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers.
Muirhead GJ, Faulkner S, Harness JA, Taubel J
Br J
Clin Pharmacol 2002 Feb;53 Suppl 1:37S-43S
simvastatin: Info
PubMed
In vitro metabolism of simvastatin in humans [SBT]identification of
metabolizing enzymes and effect of the drug on hepatic P450s.
Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison
BH, Vyas KP
Drug
Metab Dispos 1997 Oct;25(10):1191-1199
sirolimus: Info
PubMed
star fruit:
PubMed
tacrolimus (FK506): Info
PubMed
Tacrolimus oral bioavailability doubles with coadministration of
ketoconazole.
Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP,
Hebert MF
Clin
Pharmacol Ther 1997 Jul;62(1):41-49
Identification of drugs inhibiting the in vitro metabolism of tacrolimus
by human liver microsomes.
Christians U, Schmidt G, Bader A, Lampen A, Schottmann R, Linck A, Sewing
KF
Br
J Clin Pharmacol 1996 Mar;41(3):187-190
Metabolism of the immunosuppressant tacrolimus in the small intestine:
cytochrome P450, drug interactions, and interindividual variability.
Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior
AK, Dralle H, Hackbarth I, Sewing KF
Drug
Metab Dispos 1995 Dec;23(12):1315-1324
Metabolism of FK506, a potent immunosuppressive agent, by cytochrome P450
3A enzymes in rat, dog and human liver microsomes.
Shiraga T, Matsuda H, Nagase K, Iwasaki K, Noda K, Yamazaki H, Shimada T,
Funae Y
Biochem
Pharmacol 1994 Feb 11;47(4):727-735
Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506
and rapamycin in man and rat.
Sattler M, Guengerich FP, Yun CH, Christians U, Sewing KF
Drug
Metab Dispos 1992 Sep;20(5):753-761
In vitro metabolism of FK506 in rat, rabbit and human liver microsomes:
identification of a major metabolite and of cytochrome P450 3A as the major
enzyme responsible for its metabolism.
Vincent SH, Karanam BV, Painter SK, Chiu SHL
Arch
Biochem Biophys 192;294(2):454-460
tamoxifen:
PubMed
Delineation of human cytochromes P450 involved in the metabolism of
tamoxifen.
Daniels, L., Blankson, E.A., Henderson, C.J., Harris, A.H., Wolf, C.R., Lennard,
M.S., and Tucker, G.T
Br J Clin Pharmacol 33:153P, 1992.
taxol: Info
PubMed
telithromycin: PubMed
terfenadine: Info
PubMed
Oxidation of the antihistaminic drug terfenadine
in human liver microsomes. Role of cytochrome P-450 3A(4) in -dealkylation
and C-hydroxylation.
Yun CH, Okerholm RA, Guengerich FP
Drug
Metab Dispos 1993 May-Jun;21(3):403-9
testosterone: Info
PubMed
trazodone: Info
PubMed
Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human
sources.
Rotzinger S, Fang J, Baker GB
Drug
Metab Dispos 1998 Jun;26(6):572-575
triazolam: Info
PubMed
Triazolam biotransformation by human liver microsomes in vitro: effects
of metabolic inhibitors and clinical confirmation of a predicted interaction
with ketoconazole.
von Moltke LL, Greenblatt DJ, Harmatz JS, Duan SX, Harrel LM, Cotreau-Bibbo
MM, Pritchard GA, Wright CE, Shader RI
J
Pharmacol Exp Ther 1996 Feb;276(2):370-379
verapamil: Info
PubMed
Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein
for a novel cysteine protease inhibitor.
Zhang Y, Guo X, Lin ET, Benet LZ
Drug
Metab Dispos 1998 Apr;26(4):360-6
vincristine: Info
PubMed
Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL
Bohme A, Ganser A, Hoelzer D
Ann
Hematol 1995 Dec;71(6):311-2
Vincristine toxicity in five children with acute lymphoblastic
leukaemia.
Murphy JA, Ross LM, Gibson BE
Lancet
1995 Aug 12;346(8972):443
zaleplon: Info
PubMed
Metabolism of Zaleplon by human hepatic microsomal cytochrome P450
isoforms.
Renwick AB, Mistry H, Ball SE, Walters DG, Kao J, Lake BG
Xenobiotica
1998 Apr;28(4):337-48
ziprasidone PubMed
Ziprasidone metabolism, aldehyde oxidase, and clinical implications.
Beedham C, Miceli JJ, Obach RS.
J Clin Psychopharmacol. 2003 Jun;23(3):229-32.
zolpidem: Info
PubMed
Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors,
and in vivo correlations.
Von Moltke LL, Greenblatt DJ, Granda BW, D
Br
J Clin Pharmacol 1999 Jul;48(1):89-97
| » APREPITANT |
[ PubMed ] |
| Article | Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. |
| Authors | Shadle CR, Lee Y, Majumdar AK, Petty KJ, Gargano C, Bradstreet TE, Evans JK, Blum RA. |
| Link | J Clin Pharmacol. 2004 Mar;44(3):215-23.
|
| Article | Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe. |
| Authors | Majumdar AK, McCrea JB, Panebianco DL, Hesney M, Dru J, Constanzer M, Goldberg MR, Murphy G, Gottesdiener KM, Lines CR, Petty KJ, Blum RA. |
| Link | Clin Pharmacol Ther. 2003 Aug;74(2):150-6.
|
| Article | Aprepitant: a novel antiemetic for chemotherapy-induced nausea and vomiting. |
| Authors | Massaro AM, Lenz KL. |
| Link | Ann Pharmacother. 2005 Jan;39(1):77-85.
|
| Article | Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. |
| Authors | Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE. |
| Link | Drug Metab Dispos. 2004 Nov;32(11):1287-92.
|
| Article | Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone. |
| Authors | McCrea JB, Majumdar AK, Goldberg MR, Iwamoto M, Gargano C, Panebianco DL, Hesney M, Lines CR, Petty KJ, Deutsch PJ, Murphy MG, Gottesdiener KM, Goldwater DR, Blum RA. |
| Link | Clin Pharmacol Ther. 2003 Jul;74(1):17-24.
|
| Article | Evaluation of potential inductive effects of aprepitant on cytochrome P450 3A4 and 2C9 activity. |
| Authors | Shadle CR, Lee Y, Majumdar AK, Petty KJ, Gargano C, Bradstreet TE, Evans JK, Blum RA. |
| Link | J Clin Pharmacol. 2004 Mar;44(3):215-23.
|
| Info | www.rxlist.com |
azithromycin: Info
PubMed
ciprofloxacin: Info
PubMed
Methadone, ciprofloxacin, and adverse drug reactions.
Herrlin K, Segerdahl M, Gustafsson LL, Kalso E
Lancet
2000 Dec 16;356(9247):2069-70
Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal
drug metabolism in rat and human
McLellan RA, Drobitch RK, Monshouwer M, Renton KW
Drug
Metab Dispos 1996 Oct;24(10):1134-8
| » CLARITHROMYCIN |
[ PubMed ] |
| Article | Oxidative metabolism of clarithromycin in the presence of human liver microsomes. Major role for the cytochrome P4503A (CYP3A) subfamily. |
| Authors | Rodrigues AD, Roberts EM, Mulford DJ, Yao Y, Ouellet D. |
| Link | Metab Dispos 1997 May;25(5):623-630
|
| Article | Effects of clarithromycin on cytochrome P450. Comparison with other macrolides. |
| Authors | Tinel M, Descatoire V, Larrey D, Loeper J, Labbe G, Letteron P, Pessayre D. |
| Link | Pharmacol Exp Ther 1989;250(2):746-751.
|
| Article | Interaction between FK506 and clarithromycin in a renal transplant patient. |
| Authors | Wolter K, Wagner K, Philipp T, Fritschka E. |
| Link | Eur J Clin Pharmacol 1994;47:207-208.
|
| Article | Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. |
| Authors | Gurley B, Hubbard MA, Williams DK, Thaden J, Tong Y, Gentry WB, Breen P, Carrier DJ, Cheboyina S. |
| Link | J Clin Pharmacol. 2006 Feb;46(2):201-13.
|
| Article | Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobacter pylori eradication therapy assessed by changes in plasma lansoprazole levels and partial cortisol clearance to 6beta-hydroxycortisol. |
| Authors | Ushiama H, Echizen H, Nachi S, Ohnishi A. |
| Link | Clin Pharmacol Ther. 2002 Jul;72(1):33-43.
|
| Info | www.rxlist.com |
| » DILTIAZEM |
[ PubMed ] |
| Article | Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. |
| Authors | Jones DR, Gorski JC, Hamman MA, Mayhew BS, Rider S, Hall SD. |
| Link | Pharmacol Exp Ther. 1999 Sep;290(3):1116-25.
|
| Article | Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting. |
| Authors | Ahonen J, Olkkola KT, Salmenperä M, Hynynen M, Neuvonen PJ. |
| Link | Anesthesiology. 1996 Dec;85(6):1246-52.
|
| Article | Diltiazem inhibits human intestinal cytochrome P450 3A (CYP3A) activity in vivo without altering the expression of intestinal mRNA or protein. |
| Authors | Pinto AG, Horlander J, Chalasani N, Hamman M, Asghar A, Kolwankar D, Hall SD. |
| Link | Br J Clin Pharmacol. 2005 Apr;59(4):440-6.
|
| Article | The interaction of diltiazem with simvastatin. |
| Authors | Mousa O, Brater DC, Sunblad KJ, Hall SD. |
| Link | Clin Pharmacol Ther. 2000 Mar;67(3):267-74.
|
| Info | www.rxlist.com |
delaviridine: Info
PubMed
diethyl-dithiocarbamate: Info
PubMed
Biotransformation of chloroxazone by hepatic microsomes from humans and
ten other mammalian species.
Court MH, Von Moltke LL, Shader RI, Greenblatt DJ.
Biopharm Drug Dispos 18(3):213-226; 1997
| » FLUCONAZOLE |
[ PubMed ] |
| Article | Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo. |
| Authors | von Moltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI. |
| Link | J Clin Psychopharmacol. 1996 Apr;16(2):104-12.
|
| Article | Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. |
| Authors | Gibbs MA, Thummel KE, Shen DD, Kunze KL. |
| Link | Drug Metab Dispos. 1999 Feb;27(2):180-7.
|
| Article | Fluconazole, but not terbinafine, enhances the effects of triazolam by inhibiting its metabolism. |
| Authors | Varhe A, Olkkola KT, Neuvonen PJ. |
| Link | Br J Clin Pharmacol. 1996 Apr;41(4):319-23.
|
| Info | www.rxlist.com |
| » GRAPEFRUIT JUICE |
[ PubMed ] |
| Article | Interaction between grapefruit juice and diazepam in humans. |
| Authors | Ozdemir M, Aktan Y, Boydag BS, Cingi MI, Musmul A. |
| Link | J Drug Metab Pharmacokinet 1998 Jan;23(1):55-59.
|
| Article | Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. |
| Authors | Lown KS, Bailey DG, Fontana RJ, Janardan SK, Adair CH, Fortlage LA, Brown MB, Guo W, Watkins PB. |
| Link | Clin Invest 1997 May 15;99(10):2545-2553.
|
| Article | Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir. |
| Authors | Culm-Merdek KE, von Moltke LL, Gan L, Horan KA, Reynolds R, Harmatz JS, Court MH, Greenblatt DJ. |
| Link | Clin Pharmacol Ther. 2006 Mar;79(3):243-54.
|
| Article | Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. |
| Authors | Veronese ML, Gillen LP, Burke JP, Dorval EP, Hauck WW, Pequignot E, Waldman SA, Greenberg HE. |
| Link | J Clin Pharmacol. 2003 Aug;43(8):831-9.
|
| Article | Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. |
| Authors | Lown KS, Bailey DG, Fontana RJ, Janardan SK, Adair CH, Fortlage LA, Brown MB, Guo W, Watkins PB. |
| Link | J Clin Invest. 1997 May 15;99(10):2545-53. |
| » INDINAVIR |
[ PubMed ] |
| Article | Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir. |
| Authors | von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Duan SX, Fogelman SM, Daily JP, Harmatz JS, Shader RI. |
| Link | J Clin Pharmacol. 1998 Feb;38(2):106-11.
|
| Article | Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. |
| Authors | Chiba M, Hensleigh M, Nishime JA, Balani SK, Lin JH |
| Link | Drug Metab Dispos 1996 Mar;24(3):307-14.
|
| Info | www.rxlist.com |
| » KETOCONAZOLE |
[ PubMed ] |
| Article | Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo. |
| Authors | von Moltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI. |
| Link | J Clin Psychopharmacol. 1996 Apr;16(2):104-12.
|
| Article | Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture. |
| Authors | Maurice M, Pichard L, Daujat M. Fabre I, Joyeux H, Domergue J, Maurel P. |
| Link | FASEB J. 1992;6:752-758.
|
| Article | Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals. |
| Authors | Moody DE, Walsh SL, Rollins DE, Neff JA, Huang W. |
| Link | Clin Pharmacol Ther. 2004 Aug;76(2):154-66.
|
| Article | Influence of ketoconazole on the fecal and urinary disposition of docetaxel. |
| Authors | Engels FK, Loos WJ, Mathot RA, van Schaik RH, Verweij J. |
| Link | Cancer Chemother Pharmacol. 2007 Sep;60(4):569-79.
|
| Info | www.rxlist.com |
mibefradil: Info
Pubmed
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both
P-glycoprotein and CYP3A in vitro.
Wandel C, Kim RB, Guengerich FP, Wood AJ
Drug
Metab Dispos 2000 Aug;28(8):895-8
| » NEFAZODONE |
[ PubMed ] |
| Article | Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole. |
| Authors | von Moltke LL, Greenblatt DJ, Harmatz JS, Duan SX, Harrel LM, Cotreau-Bibbo MM, Pritchard GA, Wright CE, Shader RI. |
| Link | J Pharmacol Exp Ther 1996 Feb;276(2):370-379.
|
| Article | Interactions between cyclosporine and newer antidepressant medications. |
| Authors | Vella JP, Sayegh MH. |
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| » NELFINAVIR |
[ PubMed ] |
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norfloxacin: Info
PubMed
Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal
drug metabolism in rat and human
McLellan RA, Drobitch RK, Monshouwer M, Renton KW
Drug
Metab Dispos 1996 Oct;24(10):1134-8
norfluoxetine: Info
PubMed
Drug Therapy: Fluoxetine.
Brosen K
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| » RITONAVIR |
[ PubMed ] |
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saquinavir: Info
PubMed
| » TELITHROMYCIN |
[ PubMed ] |
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| » VERAPAMIL |
[ PubMed ] |
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voriconazole :
PubMed
Drug-drug interaction of antifungal drugs
Niwa T, Shiraga T, Takagi A
Yakugaku Zasshi. 2005 Oct;125(10):795-805.
| » PIOGLITAZONE |
[ PubMed ] |
| Article | Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects. |
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| Info | www.rxlist.com |
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