The Krannert Institute of Cardiology has a rich history of basic science, translational, and clinical research in all aspects of cardiovascular medicine. Our physician-investigators believe in not only practicing evidence-based medicine but also in participating in clinical research that generates the evidence. Therefore, we are devoted to developing and improving the care of patients through innovative clinical research and are committed to serving our patients by integrating patient care, education and clinical research into our overall mission.

If you are a patient, sponsor, or potential collaborator and would like additional information, please contact our Clinical Research Adminisitrator, Pam DeWeese, MAT, CCRP, at pdeweese@iupui.edu.

Electrophysiology Cardiology Description The Krannert Institute is currently conducting clinical research studies to evaluate the safety and effectiveness of devices and ablation systems used to treat heart rhythm disturbances. Potential Participants Adults with heart rhythm disturbances requiring pacemakers, defibrillators (ICD), or ablations. Research Team Dr. John Miller, Director and Principal Investigator (PI) Dr. Deepak Bhakta (PI) Dr. Mithilesh Das (PI) Dr. William Groh (PI) Dr. Anil Yadav (PI) For More Information Contact research coordinators: Susan Straka - sstraka@iupui.edu or (317) 962-0073 Jeri Steward - steward3@iupui.edu or (317) 962-0080

Echocardiography Description The Krannert Institute is currently conducting clinical research studies to evaluating new techniques to evaluate heart function and to better predict outcomes, the correlation of cardiac stress testing to outcomes, alternative stress testing agents (e.g. Dopamine), prediction of sudden death and dysychrony by echocardiography, 3 D echo's ability to evaluate valvular heart disease, and outcomes of valvular heart disease using transthoracic echocardiography. Potential Participants Adults with coronary or valvular disease or persons with possible cardiac disease. Research Team Dr. Harvey Feigenbaum, Director and Principal Investigator (PI) Dr. Irmina Gradus-Pizlo (PI) Dr. Jothiharan Mahenthiran (PI) Dr. Stephen Sawada (PI) For More Information Contact research coordinators: Judy Foltz - jfoltz@iupui.edu or (317) 962-0531 Cathy Spears – cdspears@iupui.edu or 317-962-0097

Interventional Cardiology Description The Krannert Institute is currently conducting clinical research studies to evaluate the safety and effectiveness of various devices including cardiac stents and septal closure devices, as well as, comparative studies regarding revascularization treatment options for diabetics. Potential Participants Adults with documented coronary artery disease who are scheduled to undergo a cardiac catheterization. Research Team Dr. Jeffrey A. Breall, Director and Principal Investigator (PI) Dr. Islam Bolad (PI) Dr. Saihari Sadanandan (PI) Dr. Anjan Sinha (PI) Dr. Elisabeth von der Lohe (PI) For More Information Contact research coordinators: Judy Foltz - jfoltz@iupui.edu or (317) 962-0531

Congestive Heart Failure Description The Krannert Institute is currently conducting clinical research studies to evaluate the management of acute heart failure, the impact of anemia on chronic heart failure, mechanical device therapy (e.g. left ventricular assist devices (LVAD), biventricular pacemakers, and hemodynamic monitoring devices), psychosocial outcomes of specific treatments, and the impact of "heart failure clinic" on patient outcomes. Potential Participants Adults with known congestive heart failure Research Team Dr. Irmina Gradus-Pizlo, Director and Principal Investigator (PI) Dr. Masoor Kamalesh (PI) Dr. Jothiharan Mahenthiran (PI) For More Information Contact research coordinator: Cathy Spears – cdspears@iupui.edu or 317-962-0097

General Cardiology Description The Krannert Institute is currently conducting clinical research studies to evaluate the safety and effectiveness of investigational and approved drugs for the treatment of acute coronary syndrome, patients with Non ST segment elevation acute coronary syndrome, as well as observing the incidence of heart abnormalities in patients with traumatic brain injury. Potential Participants Adults presenting with acute coronary syndrome and those presenting with a traumatic brain injury. Research Team Dr. Richard Kovacs, Director and Principal Investigator (PI) Dr. John (Chris) Bailey (PI) Dr. Masoor Kamalesh (PI) For More Information Contact research coordinators: Susan Straka (Methodist Campus) - sstraka@iupui.edu or (317) 962-0073 Cathy Spears – cdspears@iupui.edu or 317-962-0097

Nuclear Cardiology Description The Krannert Institue is currently conducting clinical research studies to evaluate outcomes of cardiac stress perfusion imaging in various clinical settings, the use of new stress techniques, and the correlation of stress perfusion patterns with other cardiac tests (e.g. EKG, catheterization, CT and MRI scans.) Potential Participants Adults with known heart disease Research Team Dr. Jothiharan Mahenthiran, Director and Principal Investigator (PI) Dr. Stephen Sawada (PI) For More Information Contact research coordinator: Cathy Spears – cdspears@iupui.edu or 317-962-0097

Vascular Biology Description KIC is currently evaluating the effects of exercise on circulating endothellial progenitor cells, angiogenisis factors in pericaridal fluid, pluripotent cell differentiation and vascular modulation, protein expression and function in atherosclerosis. Potential Participants Adults undergoing an exercise stress test, adults with coronary artery disease, and adults with peripheral vascular disease. Research Team Dr. Keith March, Director and Principal Investigator For More Information Contact research coordinator: Pat G'Sell - pgsell@iupui.edu or (317) 278-6585