Department of Medicine


Publications By User Base Principal Investigators Using ICBM/O'Brien Center

PHS 398/2590 (Rev. 06/09)


1. Tian W, Li XJ, Stull ND, Ming W, Suh CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC.  Fc{gamma}R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome. Blood. 2008 Nov 1;112(9):3867-77. Epub 2008 Aug 18.


2. Gopalakrishnan S, Hallett MA, Atkinson S, Marrs JA. aPKC-Par complex dysfunction and tight junction disassembly in renal epithelial cells during ATP-depletion. Am J Physiol Cell Physiol. 2007 Mar; 292(3):C1094-102. Epub 2006 Aug 23.




1. Kher, R., Sha, E.C., Escobar, M.R., Andreoli, E.M., Wang, P., Xu, W-M., Wandinger-Ness, A., Bacallao, R.  Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture, American Journal of Physiology-Cell, 301, C99-105, 2011.


2. Thiele AT., Sumpter TL., Walker JA., Xu Q., Chang CH., Bacallao RL., Kher R., Wilkes DS. Pulmonary immunity to viral infection: adenovirus infection of lung dendritic cells renders T cells nonresponsive to interleukin-2. Journal of Virology. 80(4):1826-36, 2006.


3. Bacallao, R., Sohrab, S. and Phillips, C. Guiding principles of specimen preservation for confocal

fluorescence microscopy. The Handbook of Biological Confocal Microscopy 3nd edition, Ed. J. Pawley,

Springer-Verlag, N.Y. 368-378, 2006.


4. Kher, R. and R.L. Bacallao Imaging Gene Expression. Nephron. Exp. Nephrology. 103: e75-80, 2006.




1. Basile DP, Zeng P, Friedrich JL, Leonard EC, Yoder MC. Low proliferative potential and anti angiogenic properties of cultured rat kidney endothelial cells. Angiogenesis, Revision Submitted 2011.


2 . Basile DP, Friedrich JL, Spahic J, Knipe N, Mang H, Leonard EC, Ashtiyani SC, Bacallao RL, Molitoris BA, and Sutton TA. Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. Am J Physiol Renal Physiol: 300 F721-733, 2011.





1. Dagher, P.C., Mai, E.M., Hato, T., Lee, S., Anderson, M.D., Karozos, S.C., Mang, H.E., Knipe, N.L., Plotkin, Z., and Sutton, T.A. The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. Am. J. Physiol. Renal Physiol, in press.


2. Kalakeche, R., Hato, T., Rhodes, G., Dunn, K.W., El-Achkar, T.M., Plotkin, Z., Sandoval, R.M., and

Dagher, P.C. 2011. Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the

downstream S2 segment. J Am Soc Nephrol 22:1505-1516.


3. El-Achkar, T.M., McCracken, R., Rauchman, M., Heitmeier, M.R., Al-Aly, Z., Dagher, P.C., and Wu, X.R. 2011. Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism. Am J Physiol Renal Physiol 300:F999-1007.


4. El-Achkar, T.M., Wu, X.R., Rauchman, M., McCracken, R., Kiefer, S., and Dagher, P.C. 2008. Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression. Am J Physiol Renal Physiol 295:F534-544.


5. El-Achkar, T.M., Hosein, M., and Dagher, P.C. 2008. Pathways of renal injury in systemic gram-negative sepsis. Eur J Clin Invest 38 Suppl 2:39-44.


6. Dagher, P.C., and Basile, D.P. 2008. An expanding role of Toll-like receptors in sepsis-induced acute kidney injury. Am J Physiol Renal Physiol 294:F1048-1049.


7. El-Achkar, T.M., Plotkin, Z., Marcic, B., and Dagher, P.C. 2007. Sepsis induces an increase in thick

ascending limb Cox-2 that is TLR4 dependent. Am J Physiol Renal Physiol 293:F1187-1196.




1. Dominguez J, Wu P, Packer CS, Temm C and Kelly KJ: 2007. Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy. Am J Physiol 293: F670-F679, 2007, PCM 17596532.


2. Dominguez JH. Wu P. Hawes JW. Deeg M. Walsh J. Packer SC. Nagase M. Temm C. Goss E. Peterson R. 2006 Renal injury: similarities and differences in male and female rats with the metabolic syndrome.  Kidney International. 69(11):1969-76, 2006


Invited Review

Temm C., Dominguez JH. 2007 Microcirculation: nexus of comorbidities in diabetes. American Journal of Physiology - Renal Physiology. 293(2):F486-93,




Peer Reviewed

1. Lorenz, K., Salama, P., Dunn, K. and E. Delp. Digital correction of motion artifacts in microscopy image sequences collected from living animals using rigid and non-rigid registration. J. Micro. In press


2. Clendenon, S., Ferkowicz, M., Young, P. and K. Dunn. Deep Tissue Fluorescence Imaging in Scattering Specimens Using Confocal Microscopy. Microscopy and Microanalysis. In press.


3. Presson, R., Brown, M., Sandoval, R., Dunn, K., Lorenz, K., Delp, E., Salama, P., Molitoris, B. and

Petrache, I. Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact.  Am. J. Path. In press.


4. Dunn, K.W., Kamocka, M. and J. McDonald. 2011. A practical guide to evaluating colocalization in

biological microscopy. American Journal of Physiology (Cell). 300:C723-742


5. Lorenz, K.S., Salama, P., Dunn, K.W. and E.J. Delp. 2011. Non-rigid registration of multiphoton

microscopy images using B-splines. SPIE proceedings. 7962.


6. Young, Pamela, Clendenon, S., Byars, J. and K. Dunn. 2011. The effects of refractive index

heterogeneity within kidney tissue on multiphoton fluorescence excitation microscopy. J. Microscopy.



7. Young, Pamela, Clendenon, S., Byars, J., Decca, R. and K. Dunn. 2011. The effects of spherical

aberration on multiphoton fluorescence excitation microscopy. J. Microscopy. 242:157-165.


8. Babbey, C., Bacallao, R. and K. Dunn. 2010. Rab10 associates with primary cilia and the exocyst

complex in renal epithelial cells. Amer. J. Phys. (Renal). 299:F495-506.


9. Kamocka, M., Mu, J., Liu, X., Chen, N., Zollman, A., Sturonas-Brown, B., Dunn, K., Xu, Z., Chen, D.,

Alber, M. and E. Rosen. 2010. Two-photon intravital imaging of thrombus development. J. Biomed.

Optics 15. 15:16020-1-7.


10. Casbon, A., Allen, L., Dunn, K. and M. Dinauer. 2009. Macrophage NADPH oxidase flavocytochrome b localizes to the plasma membrane and Rab11-positive recycling endosomes. J. Immunol. 182:2325-2339.


11. Goebl, N., Babbey, C. Datta-Mannan, A., Witcher, D., Wroblewski, V. and K. Dunn. 2008. Neonatal Fc Receptor mediates internalization of Fc in transfected human endothelial cells. Mol. Biol. Cell. 19:5490-5505.


12. Muriello, Pam and Kenneth Dunn. 2008. Improving Signal Levels in Intravital Multiphoton Microscopy Using an Objective Correction Collar. Optics Communications 281:1806-1812


13. Zhou FC. Anthony B. Dunn KW. Lindquist WB. Xu ZC. Deng P. 2007. Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens. Brain Research. 1134(1):148-61.


14. Rondandino, C., Rojas, R., Ruiz, W., Wang, E., Hughey, R., Dunn, K. and G. Apodaca. 2007. RhoB-dependent modulation of postendocytotic traffic in polarized Madin Darby Canine Kidney Cells. Traffic. 8:932-949.


15. Babbey, C., Akhtar, N., Wang, E., Chen, C.-H., Grant, B. and K. Dunn. 2006. Rab10 mediates transport from sorting endosomes to common endosomes of polarized Madin-Darby canine kidney cells. Molecular Biology of the Cell. 17:3156-3175.


Non-peer reviewed

1. Dunn, Kenneth and Timothy Sutton. 2008. Functional studies in living animals using multiphoton

microscopy. ILAR Journal. 49:66-77


2. Dunn, Kenneth, Sutton, Timothy and Ruben Sandoval. 2007. Live animal imaging of renal function by multiphoton microscopy. Current Protocols in Cytometry.


3. Dunn, K. and P. Young. 2006. Principles of multiphoton microscopy. Nephron Exp. Neph. 103:33-40




1. Clendenon SG, Shah B, Miller CA, Schmeisser G, Walter A, Gattone VH, Barald KF, Liu Q, Marrs JA. Cadherin-11 controls otolith assembly: evidence for extracellular cadherin activity. Dev. Dyn. 2009. 238(8):1909-1922. PMID: 19582870




1. Kelly KJ, Kluve-Beckerman B, Zhang J and Dominguez JH. 2010. Intravenous cell therapy for acute renal failure with serum amyloid A protein reprogrammed cells. American Journal of Physiology (Renal

Physiology), 299: F453-F464, PCM 20534870


2. Kelly KJ and Dominguez JH. 2010. Treatment of the post-ischaemic inflammatory syndrome of diabetic nephropathy, Nephrol Dial Transplant 25: 3204-12,PCM 20466672.


3. Kelly KJ, Kluve-Beckerman B and Dominguez JH. 2009. Acute-phase response protein serum amyloid A stimulates renal tubule formation: studies in vitro and in vivo. American Journal of Physiology (Renal Physiol) 296: F1355-F1363, PCM 19321596


4. Kelly KJ, Burford JL and Dominguez, JH. 2009. The postischemia inflammatory syndrome: A critical

mechanism of progression in diabetic nephropathy. Am J Physiol 297: F923-931 PCM 19656916.


5. Kelly KJ, Wu P, Pattterson CE, Temm C and Dominguez JH. 2008. LOX-1 and inflammation: a new

mechanism for renal injury in obesity and diabetes. Am J Physiol 294: F1136-F1145 PCM 18322020.




1. Mason SB, Liang Y, Sinders RM, Miller CA, Eggleston-Gulyas T, Roberts R, Harris P, Gattone VH.

Disease stage characterization of hepatorenal fibrocyctic pathology in the PCK rat model of ARPKD.

Anatomical Record. 2010, Vol 239, (8) 1279-1454. PMID: 20665806.




1. Moe S, Chen N, Seifer M, Sinders R, Duan D, Chen X, liang Y, Radcliff JS, White K, Gattone VH. A rat model of chronic kidney disease-mineral bone disorder (CKD_MBD) and the effect of dietary protein source. Kidney Int. 2009. 75(2): 176-184. PMID: 18800026.


2. Chen NX, Chen X, O’Neill KD, Atkinson SJ, Moe SM. RhoA/Rho kinase (ROCK) alters fetuin-A uptake and regulates the calcification in bovine vascular smooth muscle cells (BVSMC). Am. J Physiol Renal Physiol. Sept 2009 (3):F674-80. PMCID: PMC2944289.


3. Chen NX, O’Neill KD, Chen X, Moe SM. Annexin mediated matricx vesicle calcification in vascular smooth muscle cells. J Bone Miner Res. 2008 Nov; 23(11): 1798-805. PMCID: PMC2685487.





1. Ruben M Sandoval, Mark C Wagner, Monica Patel, Silvia B Campos-Bilderback, George J Rhodes, Exing Wang, Sarah E Wean, Sherry S Clendenon, and Bruce A Molitoris. Factors influencing Glomerular Albumin in Rats. J Am Soc Nephrol. In Press. Accepted Oct 2011.


2. Wang, E, Meier DJ, Sandoval RM, Von Hendy-Willson VE, Pressler BM, Bunch RM, Alloosh M, Sturek MS, Schwartz GJ, Molitoris BA: A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney Int. Epub. 2011 Aug 31. PMID: 21881552.


3. Melican K, Sandoval RM, Kader A, Josefsson L, Tanner GA, Molitoris BA, Richter-Dahlfors A.:

Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal

colonization leading to nephrol obstruction. PLos Pathog. 2011 Feb;7(2):e1001298. Epub 2011 Feb 24.


4. Imamura R, Isaka Y, Sandoval RM, Ori A, Adamsky S, Feinstein E, Molitoris BA, Takahara; Intravital 2-Photon Microscopy Assessment of Renal Protection Efficacy of siRNA for p53 in Experimental Rat Kidney Transplantation Models. S. Cell Transplant. 2010 Aug 17.


5. Wang E, Sandoval RM, Campos SB, Molitoris BA; Rapid Diagnosis and Quantification of Acute Kidney Injury Using Fluorescent Ratio-metric Determination of Glomerular Filtration Rate in the Rat. Am J Physiol Renal Physiol. 2010 Aug 4.


6. Gupta A, Williams MD, Macias WL, Molitoris BA, Grinnell BW; Activated Protein C and Acute Kidney

Injury: Selective Targeting of PAR-1. Curr Drug Targets. 2009 Dec;10(12):1212-26.


7. Molitoris BA, Dagher P, Sandoval RM, Campos S, Ashush H, Friedman E, Brafman A, Faerman A,

Atkinson S, Thompson J, Kalinski H, Skaliter R, Erlich S, Feinstein E; siRNA Targeting p53 Attenuates

Ischemic and Cisplatin-Induced Acute Kidney Injury. J Am Soc Nephrol, 2009 Aug;20(8):1754-64.


8. Russo LM, Sandoval RM, Campos SB, Molitoris BA, Comper WD, Brown D: Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy. J Am Soc Nephrol, 2009, 20:489-94.


9. Sharfuddin AA, Sandoval RM, Berg DT, McDougal GE, Campos SB, Phillips CL, Jones BE, Gupta A, Grinnell BW, Molitoris BA: Soluble Thrombomodulin Protects Ischemic Kidneys. J Am Soc Nephrol, 2009, 20:524-534.


10. Campos-Bilderback S, Ashworth S, Wean S, Hosford M, Sandoval RM, Hallett M, Atkinson S, Molitoris B: Cytokine induced F-actin reorganization in endothelial cells involves RhoA activation. Amer J Physiol-Renal, 2009 Mar; 296(3):F487-95.


11. Melican K, Boekel J, Mansson LE, Sandoval RM, Tanner GA, Kallskag O, Palm F, Molitoris BA, Richter-Dahlfors A: Bacterial infection-mediated mucosal signaling induces local renal ischaemia as a defence against sepsis. Cell Microbiol 10(10):1987-98.


12. Russo LM, Sandoval RM, McKee M, Osicka TM, Collins AB, Brown D, Molitoris BA, Comper WD: The Normal Kidney Filters Nephrotic Levels of Albumin Retrieved By Proximal Tubule Cells: Retrieval is Disrupted in Nephrotic States. Kidney Int 71(6):504-13, 2007.


13. Yu W, Sandoval RM, Molitoris BA: Rapid Determination of Renal Filtration Function Using an Optical Ratiometric Imaging Approach. Am J Physiol-Renal Physiol 292:F1873-80, 2007. Transport in the Rat Kidney In Vivo Visualized by Time-Resolved Two-Photon Microscopy. Kidney Int 72(4):422-9, 2007.


14. Mansson LE, Melican K, Boekel J, Sandoval RM, Hautefort I, Tanner GA, Molitoris BA, Richter-Dahlfors A: Real-time Studies of the Progression of Bacterial Infections and Immediate Tissue Responses in Live Animals. Cell Microbiol 9:413-24, 2007


15. Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW: Activated Protein C Ameliorates LPS-induced Acute Kidney Injury and Downregulates Renal INOS and Angiotensin 2. Am J Physiol-Renal Physiol 293:F245-54, 2007.


16. Sandoval RM, Reilly JP, Running W, Campos SB, Santos JR, Phillips CL, Molitoris BA: A Non-nephrotoxic Gentamicin Congener that Retains Antimicrobial Efficacy. J Am Soc Nephrol 17:2697-705, 2006


17. Suurna MV, Ashworth SL, Hosford M, Sandoval RM, Wean SE, Shah BM, Bamburg JR, Molitoris BA: Colfilin Mediates ATP Depletion-induced Endothelial Cell Actin Alterations. Am J Physiol-Renal Physiol 290:F1398-407, 2006.


Non-peer reviewed

1. Molitoris BA, Sandoval RM. Kidney endothelial dysfunction: ischemia, localized infections and sepsis. Contrib. Nephrol. 2011; 174:108-18.


2. Sharfuddin, A. and Molitoris BA.: Pathophysiology of Ischemic Acute Kidney Injury. Nat Rev Nephrol

PMID 21364518 March 2011.


3. Molitoris BA, Sandoval RM: Multiphoton Imaging Techniques in Acute Kidney Injury. Contrib Nephrol. 2010;165:46-53. Epub 2010 Apr 20.


4. Molitoris BA, Sandoval RM: Techniques to study nephron function: microscopy and imaging. Pflugers Arch 2009 May;459(1):203-9.


5. Sharfuddin AA, Sandoval RM, Molitoris BA: Imaging Techniques in acute kidney injury. Nephron Clin Pract. 2008;109(4):c198-204.


6. Sandoval RM, Molitoris BA: Quantifying endocytosis in vivo using intravital two-photon microscopy.

Methods Mol Biol 440:389-402, 2008.


7. Grinnell BW, Gupta A, Sandoval R, Molitoris BA: Multiphoton microscopy: Linking drug mechanism to disease physiology. Am Pharm Rev 10(7):68-73, 2007.


8. Mansson LE, Melican K, Molitoris BA, Richter-Dahlfors A: Progression of bacterial infections studied in real time—novel perspectives provided by multiphoton microscopy. Cell Microbiol 9(10):2334-43, 2007.


9. Molitoris BA, Sandoval RM: Quantifying Dynamic Kidney Processes Utilizing Multiphoton Microscopy. Contrib Nephrol 156:227-35, 2007.


10. Ashworth SL, Sandoval RM, Tanner GA, Molitoris BA: Two-photon Microscopy: Visualization of Kidney Dynamics. Kidney Int 72(4):416-21, 2007.


11. Herget-Rosenthal S, Molitoris BA: Advances in Imaging the Kidney and Cellular Processes. Nephron Exp Nephrol. 103: e31-2, Mar 10, 2006.


12. Molitoris BA, Sandoval RM: Pharmacophotonics: Utilizing Multiphoton Microscopy To Quantify Drug Delivery and Intracellular Trafficking in the Kidney. Adv Drug Deliv Rev. 58:809-23, 2006.




1. Lee, S., Hörbelt, M., Mang, H.E., Knipe, N.L., Bacallao, R.L., Sado, Y., and Sutton, T.A. MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury. Am. J. Physiol. Renal Physiol, 301:F101-F109, 2011. PMCID: PMC3129879


2. Sutton, T.A., Wilkinson, J., Mang, H.E., Knipe, N.L., Plotkin, Z., Hosein, M., Zak, K.M., Wittenborn, J., and Dagher, P.C. P53 regulates the renal expression of HIF-1α and pVHL under physiologic conditions and after ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol., 295: F1666-77, 2008. PMCID:PMC2604829.


3. Kwon, O., Hong, S.M., Sutton, T.A., and Temm, C.J. Preservation of peritubular capillary endothelial

integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury. Am. J. Physiol. Renal Physiol, Am. J. Physiol. Renal Physiol, 295: F351 - F359, 2008. PMCID: PMC2519188.


4. Sutton, Timothy and Kenneth Dunn. 2008. Combining microscopy with in vivo imaging. Genetic

Engineering News. 28:32-33


5. Hörbelt, M., Young, S., Mang, H.E., Knipe, N.L., Sado, Y., Kribben, A., and Sutton, T.A. Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury. Am. J. Physiol. Renal Physiol, 293: F688-F695, 2007.


6. Hörbelt, M, Wotzlaw, C., Sutton, T.A., Molitoris, B.A., Phillip, T., Kribben, A., Fandrey, J. and Pietruck, F. Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy. Kidney Int. 72: 422-429, 2007.


Invited Reviews

1. Sutton, T.A. Alteration of microvascular permeability in acute kidney injury. <invited review> Microvasc. Res., 77: 4-7, 2009. PMCID: PMC2680138.


2. Sutton, T.A., Hörbelt, M., and Sandoval, R.M. Imaging Vascular Pathology. <invited review> Nephron 103: p82-p85, 2006.




1. Wagner MC, Molnar EE, Molitoris BA, Goebl MG. 2006 Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerevisiae. Antimicrob Agents Chemother. 50:587-595. PMID 16436714


2. Wagner, MC, Rhodes, G., Wang, E., Pruthi, V., Arif, E., Saleem, MA., Wean, SE., Garg, P., Verma, R., Holzman,LB., Gattone, V., Molitoris, BA., Nihalani, D. Dec 2008, Ischemic Injury to Kidney Induces

Glomerular Podoctye Effacement and Dissociation of Slit Diaphragm Proteins Neph1 and ZO-1. J Biol

Chem. 283:35579-35589. PMID:18922801.


3. Yip, MF., Ramm, G., Larance, M., Hoehn, KL., Wagner, MC., Guilhaus, M., and James, DE. Nov 2008, CaMKII-mediated Phosphorylation of the Myosin Motor Myo1c Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes. Cell Metabolism 8:384-398. PMID: 19046570


4. Lin L, Wagner MC, Cocklin R, Kuzma A, Harrington M, Molitoris BA, Goebl MG 2011, The antibiotic

gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases. Antimicrob Agents Chemother. 55:246-254. PMID 20956596.


5. Arif E, Wagner MC, Johnstone DB, Wong HN, George B, Pruthi PA, Lazzara MJ, Nihalani D 2011. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Mol Cell Biol 31:2134-50. PMID 21402783



PHS 398/2590 (Rev. 06/09)